Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women.

Variable expression is one aspect of the heterogeneity of asthma. We aimed to define a variable pattern, which is relevant in general health epidemiological cohorts. Our objectives were to assess whether: 1) asthma patterns defined using simple asthma questions through repeated measurements could re...

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Autores principales:	Margaux Sanchez, Jean Bousquet, Nicole Le Moual, Bénédicte Jacquemin, Françoise Clavel-Chapelon, Marc Humbert, Francine Kauffmann, Pascale Tubert-Bitter, Raphaëlle Varraso
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f5e5c578dd944ed95cff8dd640be23d
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spelling	oai:doaj.org-article:3f5e5c578dd944ed95cff8dd640be23d2021-11-18T07:43:27ZTemporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women.1932-620310.1371/journal.pone.0065090https://doaj.org/article/3f5e5c578dd944ed95cff8dd640be23d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23741466/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Variable expression is one aspect of the heterogeneity of asthma. We aimed to define a variable pattern, which is relevant in general health epidemiological cohorts. Our objectives were to assess whether: 1) asthma patterns defined using simple asthma questions through repeated measurements could reflect disease variability 2) these patterns may further be classified according to asthma severity/control. Among 70,428 French women, we used seven questionnaires (1992-2005) and a comprehensive reimbursement database (2004-2009) to define three reliable asthma patterns based on repeated positive answers to the ever asthma attack question: "never asthma" (n = 64,061); "inconsistent" ("yes" followed by "no", n = 3,514); "consistent" (fully consistent positive answers, n = 2,853). The "Inconsistent" pattern was related to both long-term (childhood-onset asthma with remission in adulthood) and short-term (reported asthma attack in the last 12 months, associated with asthma medication) asthma variability, showing that repeated questions are relevant markers of the variable expression of asthma. Furthermore, in this pattern, the number of positive responses (1992-2005) predicted asthma drug consumption in subsequent years, a marker of disease severity. The "Inconsistent" pattern is a phenotype that may capture the variable expression of asthma. Repeated answers, even to a simple question, are too often neglected.Margaux SanchezJean BousquetNicole Le MoualBénédicte JacqueminFrançoise Clavel-ChapelonMarc HumbertFrancine KauffmannPascale Tubert-BitterRaphaëlle VarrasoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e65090 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Margaux Sanchez Jean Bousquet Nicole Le Moual Bénédicte Jacquemin Françoise Clavel-Chapelon Marc Humbert Francine Kauffmann Pascale Tubert-Bitter Raphaëlle Varraso Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women.
description	Variable expression is one aspect of the heterogeneity of asthma. We aimed to define a variable pattern, which is relevant in general health epidemiological cohorts. Our objectives were to assess whether: 1) asthma patterns defined using simple asthma questions through repeated measurements could reflect disease variability 2) these patterns may further be classified according to asthma severity/control. Among 70,428 French women, we used seven questionnaires (1992-2005) and a comprehensive reimbursement database (2004-2009) to define three reliable asthma patterns based on repeated positive answers to the ever asthma attack question: "never asthma" (n = 64,061); "inconsistent" ("yes" followed by "no", n = 3,514); "consistent" (fully consistent positive answers, n = 2,853). The "Inconsistent" pattern was related to both long-term (childhood-onset asthma with remission in adulthood) and short-term (reported asthma attack in the last 12 months, associated with asthma medication) asthma variability, showing that repeated questions are relevant markers of the variable expression of asthma. Furthermore, in this pattern, the number of positive responses (1992-2005) predicted asthma drug consumption in subsequent years, a marker of disease severity. The "Inconsistent" pattern is a phenotype that may capture the variable expression of asthma. Repeated answers, even to a simple question, are too often neglected.
format	article
author	Margaux Sanchez Jean Bousquet Nicole Le Moual Bénédicte Jacquemin Françoise Clavel-Chapelon Marc Humbert Francine Kauffmann Pascale Tubert-Bitter Raphaëlle Varraso
author_facet	Margaux Sanchez Jean Bousquet Nicole Le Moual Bénédicte Jacquemin Françoise Clavel-Chapelon Marc Humbert Francine Kauffmann Pascale Tubert-Bitter Raphaëlle Varraso
author_sort	Margaux Sanchez
title	Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women.
title_short	Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women.
title_full	Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women.
title_fullStr	Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women.
title_full_unstemmed	Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women.
title_sort	temporal asthma patterns using repeated questionnaires over 13 years in a large french cohort of women.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/3f5e5c578dd944ed95cff8dd640be23d
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Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women.

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