Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme

Pyridoxal 5’-phosphate (PLP) is a ubiquitous co factor for diverse enzymes, among them aspartate aminotransferase. Here the authors use neutron crystallography, which allows the visualization of the positions of hydrogen atoms, and computation to characterize the catalytic mechanism of the enzyme.

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Autores principales:	Steven Dajnowicz, Ryne C. Johnston, Jerry M. Parks, Matthew P. Blakeley, David A. Keen, Kevin L. Weiss, Oksana Gerlits, Andrey Kovalevsky, Timothy C. Mueser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f5fbae599884609a7b1076b862da5d3
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spelling	oai:doaj.org-article:3f5fbae599884609a7b1076b862da5d32021-12-02T14:40:59ZDirect visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme10.1038/s41467-017-01060-y2041-1723https://doaj.org/article/3f5fbae599884609a7b1076b862da5d32017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01060-yhttps://doaj.org/toc/2041-1723Pyridoxal 5’-phosphate (PLP) is a ubiquitous co factor for diverse enzymes, among them aspartate aminotransferase. Here the authors use neutron crystallography, which allows the visualization of the positions of hydrogen atoms, and computation to characterize the catalytic mechanism of the enzyme.Steven DajnowiczRyne C. JohnstonJerry M. ParksMatthew P. BlakeleyDavid A. KeenKevin L. WeissOksana GerlitsAndrey KovalevskyTimothy C. MueserNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Steven Dajnowicz Ryne C. Johnston Jerry M. Parks Matthew P. Blakeley David A. Keen Kevin L. Weiss Oksana Gerlits Andrey Kovalevsky Timothy C. Mueser Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme
description	Pyridoxal 5’-phosphate (PLP) is a ubiquitous co factor for diverse enzymes, among them aspartate aminotransferase. Here the authors use neutron crystallography, which allows the visualization of the positions of hydrogen atoms, and computation to characterize the catalytic mechanism of the enzyme.
format	article
author	Steven Dajnowicz Ryne C. Johnston Jerry M. Parks Matthew P. Blakeley David A. Keen Kevin L. Weiss Oksana Gerlits Andrey Kovalevsky Timothy C. Mueser
author_facet	Steven Dajnowicz Ryne C. Johnston Jerry M. Parks Matthew P. Blakeley David A. Keen Kevin L. Weiss Oksana Gerlits Andrey Kovalevsky Timothy C. Mueser
author_sort	Steven Dajnowicz
title	Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme
title_short	Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme
title_full	Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme
title_fullStr	Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme
title_full_unstemmed	Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme
title_sort	direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3f5fbae599884609a7b1076b862da5d3
work_keys_str_mv	AT stevendajnowicz directvisualizationofcriticalhydrogenatomsinapyridoxal5phosphateenzyme AT rynecjohnston directvisualizationofcriticalhydrogenatomsinapyridoxal5phosphateenzyme AT jerrymparks directvisualizationofcriticalhydrogenatomsinapyridoxal5phosphateenzyme AT matthewpblakeley directvisualizationofcriticalhydrogenatomsinapyridoxal5phosphateenzyme AT davidakeen directvisualizationofcriticalhydrogenatomsinapyridoxal5phosphateenzyme AT kevinlweiss directvisualizationofcriticalhydrogenatomsinapyridoxal5phosphateenzyme AT oksanagerlits directvisualizationofcriticalhydrogenatomsinapyridoxal5phosphateenzyme AT andreykovalevsky directvisualizationofcriticalhydrogenatomsinapyridoxal5phosphateenzyme AT timothycmueser directvisualizationofcriticalhydrogenatomsinapyridoxal5phosphateenzyme
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Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme

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