Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles

Gastrointestinal absorption remains indispensable in the systemic delivery of most drugs, even though it presents several challenges that, paradoxically, may also provide opportunities that can be exploited to achieve maximal bioavailability. Drug delivery systems made from nanoparticle carriers and...

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Autores principales:	Sui Ling Janet Tan, Nashiru Billa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nanoparticle nanostructured lipid carrier solid lipid nanoparticle muco-adhesion polymer gastrointestinal Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/3f609f0dfa6e401e8ce004537db8d914
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spelling	oai:doaj.org-article:3f609f0dfa6e401e8ce004537db8d9142021-11-25T18:40:54ZImproved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles10.3390/pharmaceutics131118171999-4923https://doaj.org/article/3f609f0dfa6e401e8ce004537db8d9142021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1817https://doaj.org/toc/1999-4923Gastrointestinal absorption remains indispensable in the systemic delivery of most drugs, even though it presents several challenges that, paradoxically, may also provide opportunities that can be exploited to achieve maximal bioavailability. Drug delivery systems made from nanoparticle carriers and especially, lipid carriers, have the potential to traverse gastrointestinal barriers and deploy in the lymphatic pathway, which aptly, is free from first pass via the liver. Several poorly soluble drugs have presented improved systemic bioavailability when couriered in lipid nanoparticle carriers. In this review, we propose an additional frontier to enhancing the bioavailability of poorly soluble drugs when encapsulated in lipid nano-carriers by imparting muco-adhesion to the particles through application of appropriate polymeric coating to the lipid carrier. The combined effect of gastrointestinal muco-adhesion followed by lymphatic absorption is a promising approach to improving systemic bioavailability of poorly soluble drugs following oral administration. Evidence to the potential of this approach is backed-up by recent studies within the review.Sui Ling Janet TanNashiru BillaMDPI AGarticlenanoparticlenanostructured lipid carriersolid lipid nanoparticlemuco-adhesionpolymergastrointestinalPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1817, p 1817 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticle nanostructured lipid carrier solid lipid nanoparticle muco-adhesion polymer gastrointestinal Pharmacy and materia medica RS1-441
spellingShingle	nanoparticle nanostructured lipid carrier solid lipid nanoparticle muco-adhesion polymer gastrointestinal Pharmacy and materia medica RS1-441 Sui Ling Janet Tan Nashiru Billa Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles
description	Gastrointestinal absorption remains indispensable in the systemic delivery of most drugs, even though it presents several challenges that, paradoxically, may also provide opportunities that can be exploited to achieve maximal bioavailability. Drug delivery systems made from nanoparticle carriers and especially, lipid carriers, have the potential to traverse gastrointestinal barriers and deploy in the lymphatic pathway, which aptly, is free from first pass via the liver. Several poorly soluble drugs have presented improved systemic bioavailability when couriered in lipid nanoparticle carriers. In this review, we propose an additional frontier to enhancing the bioavailability of poorly soluble drugs when encapsulated in lipid nano-carriers by imparting muco-adhesion to the particles through application of appropriate polymeric coating to the lipid carrier. The combined effect of gastrointestinal muco-adhesion followed by lymphatic absorption is a promising approach to improving systemic bioavailability of poorly soluble drugs following oral administration. Evidence to the potential of this approach is backed-up by recent studies within the review.
format	article
author	Sui Ling Janet Tan Nashiru Billa
author_facet	Sui Ling Janet Tan Nashiru Billa
author_sort	Sui Ling Janet Tan
title	Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles
title_short	Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles
title_full	Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles
title_fullStr	Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles
title_full_unstemmed	Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles
title_sort	improved bioavailability of poorly soluble drugs through gastrointestinal muco-adhesion of lipid nanoparticles
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3f609f0dfa6e401e8ce004537db8d914
work_keys_str_mv	AT suilingjanettan improvedbioavailabilityofpoorlysolubledrugsthroughgastrointestinalmucoadhesionoflipidnanoparticles AT nashirubilla improvedbioavailabilityofpoorlysolubledrugsthroughgastrointestinalmucoadhesionoflipidnanoparticles
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Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles

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