A modular tool to query and inducibly disrupt biomolecular condensates

Here, the authors present DisCo (Disassembly of Condensates), a method that allows the fast, inducible, and specific disruption of tagged condensates in mammalian cells. DisCo uses chemical dimerizers to induce the recruitment of a ligand into condensates leading to condensate disassembly.

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Autores principales:	Carmen N. Hernández-Candia, Sarah Pearce, Chandra L. Tucker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f62c88d9f6e476888735920ba503f07
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:3f62c88d9f6e476888735920ba503f072021-12-02T13:24:12ZA modular tool to query and inducibly disrupt biomolecular condensates10.1038/s41467-021-22096-12041-1723https://doaj.org/article/3f62c88d9f6e476888735920ba503f072021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22096-1https://doaj.org/toc/2041-1723Here, the authors present DisCo (Disassembly of Condensates), a method that allows the fast, inducible, and specific disruption of tagged condensates in mammalian cells. DisCo uses chemical dimerizers to induce the recruitment of a ligand into condensates leading to condensate disassembly.Carmen N. Hernández-CandiaSarah PearceChandra L. TuckerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carmen N. Hernández-Candia Sarah Pearce Chandra L. Tucker A modular tool to query and inducibly disrupt biomolecular condensates
description	Here, the authors present DisCo (Disassembly of Condensates), a method that allows the fast, inducible, and specific disruption of tagged condensates in mammalian cells. DisCo uses chemical dimerizers to induce the recruitment of a ligand into condensates leading to condensate disassembly.
format	article
author	Carmen N. Hernández-Candia Sarah Pearce Chandra L. Tucker
author_facet	Carmen N. Hernández-Candia Sarah Pearce Chandra L. Tucker
author_sort	Carmen N. Hernández-Candia
title	A modular tool to query and inducibly disrupt biomolecular condensates
title_short	A modular tool to query and inducibly disrupt biomolecular condensates
title_full	A modular tool to query and inducibly disrupt biomolecular condensates
title_fullStr	A modular tool to query and inducibly disrupt biomolecular condensates
title_full_unstemmed	A modular tool to query and inducibly disrupt biomolecular condensates
title_sort	modular tool to query and inducibly disrupt biomolecular condensates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3f62c88d9f6e476888735920ba503f07
work_keys_str_mv	AT carmennhernandezcandia amodulartooltoqueryandinduciblydisruptbiomolecularcondensates AT sarahpearce amodulartooltoqueryandinduciblydisruptbiomolecularcondensates AT chandraltucker amodulartooltoqueryandinduciblydisruptbiomolecularcondensates AT carmennhernandezcandia modulartooltoqueryandinduciblydisruptbiomolecularcondensates AT sarahpearce modulartooltoqueryandinduciblydisruptbiomolecularcondensates AT chandraltucker modulartooltoqueryandinduciblydisruptbiomolecularcondensates
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A modular tool to query and inducibly disrupt biomolecular condensates

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