Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure

Takaaki Furihata et al. report a new mouse model with heart-specific deletion of the mitochondrial protein, mitoNEET. Their results suggest that loss of mitoNEET expression may contribute to age-associated heart failure in older adults.

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Autores principales: Takaaki Furihata, Shingo Takada, Naoya Kakutani, Satoshi Maekawa, Masaya Tsuda, Junichi Matsumoto, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Nobuyuki Enzan, Shouji Matsushima, Haruka Handa, Yoshizuki Fumoto, Junko Nio-Kobayashi, Toshihiko Iwanaga, Shinya Tanaka, Hiroyuki Tsutsui, Hisataka Sabe, Shintaro Kinugawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3f63983eae254d919bb87225d2d4c10c
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Sumario:Takaaki Furihata et al. report a new mouse model with heart-specific deletion of the mitochondrial protein, mitoNEET. Their results suggest that loss of mitoNEET expression may contribute to age-associated heart failure in older adults.