A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development
NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1.
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Nature Portfolio
2016
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oai:doaj.org-article:3f649647fbdd4d0799d4dc0597425c492021-12-02T14:38:34ZA threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development10.1038/ncomms118412041-1723https://doaj.org/article/3f649647fbdd4d0799d4dc0597425c492016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11841https://doaj.org/toc/2041-1723NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1.Stefan Klein-HesslingRonald RudolfKhalid MuhammadKlaus-Peter KnobelochMuhammad Ahmad MaqboolPierre CauchyJean-Christophe AndrauAndris AvotsClaudio TaloraVolker EllenriederIsabella ScrepantiEdgar SerflingAmiya Kumar PatraNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Stefan Klein-Hessling Ronald Rudolf Khalid Muhammad Klaus-Peter Knobeloch Muhammad Ahmad Maqbool Pierre Cauchy Jean-Christophe Andrau Andris Avots Claudio Talora Volker Ellenrieder Isabella Screpanti Edgar Serfling Amiya Kumar Patra A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development |
| description |
NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1. |
| format |
article |
| author |
Stefan Klein-Hessling Ronald Rudolf Khalid Muhammad Klaus-Peter Knobeloch Muhammad Ahmad Maqbool Pierre Cauchy Jean-Christophe Andrau Andris Avots Claudio Talora Volker Ellenrieder Isabella Screpanti Edgar Serfling Amiya Kumar Patra |
| author_facet |
Stefan Klein-Hessling Ronald Rudolf Khalid Muhammad Klaus-Peter Knobeloch Muhammad Ahmad Maqbool Pierre Cauchy Jean-Christophe Andrau Andris Avots Claudio Talora Volker Ellenrieder Isabella Screpanti Edgar Serfling Amiya Kumar Patra |
| author_sort |
Stefan Klein-Hessling |
| title |
A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development |
| title_short |
A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development |
| title_full |
A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development |
| title_fullStr |
A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development |
| title_full_unstemmed |
A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development |
| title_sort |
threshold level of nfatc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/3f649647fbdd4d0799d4dc0597425c49 |
| work_keys_str_mv |
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1718390945166131200 |