Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy

Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy

“Satellite cells are crucial for skeletal muscle regeneration. Here the authors show that immunoglobulin superfamily containing leucine-rich repeat (Islr) promotes skeletal muscle regeneration via a mechanism involving Dishevelled-2 stabilization in satellite cells and protection from autophagy.

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Autores principales: Kuo Zhang, Yuying Zhang, Lijie Gu, Miaomiao Lan, Chuncheng Liu, Meng Wang, Yang Su, Mengxu Ge, Tongtong Wang, Yingying Yu, Chang Liu, Lei Li, Qiuyan Li, Yaofeng Zhao, Zhengquan Yu, Fudi Wang, Ning Li, Qingyong Meng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3f654eba92714c41bb88ea27854f0718
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spelling oai:doaj.org-article:3f654eba92714c41bb88ea27854f07182021-12-02T14:38:48ZIslr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy10.1038/s41467-018-07638-42041-1723https://doaj.org/article/3f654eba92714c41bb88ea27854f07182018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07638-4https://doaj.org/toc/2041-1723“Satellite cells are crucial for skeletal muscle regeneration. Here the authors show that immunoglobulin superfamily containing leucine-rich repeat (Islr) promotes skeletal muscle regeneration via a mechanism involving Dishevelled-2 stabilization in satellite cells and protection from autophagy.Kuo ZhangYuying ZhangLijie GuMiaomiao LanChuncheng LiuMeng WangYang SuMengxu GeTongtong WangYingying YuChang LiuLei LiQiuyan LiYaofeng ZhaoZhengquan YuFudi WangNing LiQingyong MengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kuo Zhang
Yuying Zhang
Lijie Gu
Miaomiao Lan
Chuncheng Liu
Meng Wang
Yang Su
Mengxu Ge
Tongtong Wang
Yingying Yu
Chang Liu
Lei Li
Qiuyan Li
Yaofeng Zhao
Zhengquan Yu
Fudi Wang
Ning Li
Qingyong Meng
Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy
description “Satellite cells are crucial for skeletal muscle regeneration. Here the authors show that immunoglobulin superfamily containing leucine-rich repeat (Islr) promotes skeletal muscle regeneration via a mechanism involving Dishevelled-2 stabilization in satellite cells and protection from autophagy.
format article
author Kuo Zhang
Yuying Zhang
Lijie Gu
Miaomiao Lan
Chuncheng Liu
Meng Wang
Yang Su
Mengxu Ge
Tongtong Wang
Yingying Yu
Chang Liu
Lei Li
Qiuyan Li
Yaofeng Zhao
Zhengquan Yu
Fudi Wang
Ning Li
Qingyong Meng
author_facet Kuo Zhang
Yuying Zhang
Lijie Gu
Miaomiao Lan
Chuncheng Liu
Meng Wang
Yang Su
Mengxu Ge
Tongtong Wang
Yingying Yu
Chang Liu
Lei Li
Qiuyan Li
Yaofeng Zhao
Zhengquan Yu
Fudi Wang
Ning Li
Qingyong Meng
author_sort Kuo Zhang
title Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy
title_short Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy
title_full Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy
title_fullStr Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy
title_full_unstemmed Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy
title_sort islr regulates canonical wnt signaling-mediated skeletal muscle regeneration by stabilizing dishevelled-2 and preventing autophagy
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/3f654eba92714c41bb88ea27854f0718
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