The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin

Although fear memory formation is essential for survival and fear-related mental disorders, the neural circuitry and mechanism are incompletely understood. Here, we utilized trace fear conditioning to study the formation of trace fear memory in mice. We identified the entorhinal cortex (EC) as a cri...

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Autores principales:	Hemin Feng, Junfeng Su, Wei Fang, Xi Chen, Jufang He
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	fear memory entorhinal cortex lateral amygdala cholecystokinin neuroplasticity long-term potentiation Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3f687bf7b1b342bea28024c4d840aa9c
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spelling	oai:doaj.org-article:3f687bf7b1b342bea28024c4d840aa9c2021-11-29T16:43:26ZThe entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin10.7554/eLife.693332050-084Xe69333https://doaj.org/article/3f687bf7b1b342bea28024c4d840aa9c2021-11-01T00:00:00Zhttps://elifesciences.org/articles/69333https://doaj.org/toc/2050-084XAlthough fear memory formation is essential for survival and fear-related mental disorders, the neural circuitry and mechanism are incompletely understood. Here, we utilized trace fear conditioning to study the formation of trace fear memory in mice. We identified the entorhinal cortex (EC) as a critical component of sensory signaling to the amygdala. We adopted both loss-of-function and gain-of-function experiments to demonstrate that release of the cholecystokinin (CCK) from the EC is required for trace fear memory formation. We discovered that CCK-positive neurons project from the EC to the lateral nuclei of the amygdala (LA), and inhibition of CCK-dependent signaling in the EC prevented long-term potentiation of the auditory response in the LA and formation of trace fear memory. In summary, high-frequency activation of EC neurons triggers the release of CCK in their projection terminals in the LA, potentiating auditory response in LA neurons. The neural plasticity in the LA leads to trace fear memory formation.Hemin FengJunfeng SuWei FangXi ChenJufang HeeLife Sciences Publications Ltdarticlefear memoryentorhinal cortexlateral amygdalacholecystokininneuroplasticitylong-term potentiationMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fear memory entorhinal cortex lateral amygdala cholecystokinin neuroplasticity long-term potentiation Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	fear memory entorhinal cortex lateral amygdala cholecystokinin neuroplasticity long-term potentiation Medicine R Science Q Biology (General) QH301-705.5 Hemin Feng Junfeng Su Wei Fang Xi Chen Jufang He The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin
description	Although fear memory formation is essential for survival and fear-related mental disorders, the neural circuitry and mechanism are incompletely understood. Here, we utilized trace fear conditioning to study the formation of trace fear memory in mice. We identified the entorhinal cortex (EC) as a critical component of sensory signaling to the amygdala. We adopted both loss-of-function and gain-of-function experiments to demonstrate that release of the cholecystokinin (CCK) from the EC is required for trace fear memory formation. We discovered that CCK-positive neurons project from the EC to the lateral nuclei of the amygdala (LA), and inhibition of CCK-dependent signaling in the EC prevented long-term potentiation of the auditory response in the LA and formation of trace fear memory. In summary, high-frequency activation of EC neurons triggers the release of CCK in their projection terminals in the LA, potentiating auditory response in LA neurons. The neural plasticity in the LA leads to trace fear memory formation.
format	article
author	Hemin Feng Junfeng Su Wei Fang Xi Chen Jufang He
author_facet	Hemin Feng Junfeng Su Wei Fang Xi Chen Jufang He
author_sort	Hemin Feng
title	The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin
title_short	The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin
title_full	The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin
title_fullStr	The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin
title_full_unstemmed	The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin
title_sort	entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/3f687bf7b1b342bea28024c4d840aa9c
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The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin

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