Prevalence and factors associated with physical function limitation in older West African people living with HIV.
Although physical function decline is common with aging, the burden of this impairment remains underestimated in patients living with HIV (PLHIV), particularly in the older people receiving antiretroviral treatment (ART) and living in sub-Saharan Africa (SSA). PLHIV aged ≥50 years old and on ART sin...
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oai:doaj.org-article:3f6ab9aeda2d449eb2e8885954eba6b62021-12-02T20:11:28ZPrevalence and factors associated with physical function limitation in older West African people living with HIV.1932-620310.1371/journal.pone.0240906https://doaj.org/article/3f6ab9aeda2d449eb2e8885954eba6b62020-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0240906https://doaj.org/toc/1932-6203Although physical function decline is common with aging, the burden of this impairment remains underestimated in patients living with HIV (PLHIV), particularly in the older people receiving antiretroviral treatment (ART) and living in sub-Saharan Africa (SSA). PLHIV aged ≥50 years old and on ART since ≥6 months were included (N = 333) from three clinics (two in Côte d'Ivoire, one in Senegal) participating in the International epidemiological Databases to Evaluate AIDS (IeDEA) West Africa collaboration. Physical function was measured using the Short Physical Performance Battery (SPPB), the unipodal balance test and self-reported questionnaires. Grip strength was also assessed. Logistic regression was used to identify the factors associated with SPPB performance specifically. Median age was 57 (54-61) years, 57.7% were female and 82.7% had an undetectable viral load. The mean SPPB score was 10.2 ±1.8. Almost 30% had low SPPB performance with the 5-sit-to-stand test being the most altered subtest (64%). PLHIV with low SPPB performance also had significantly low performance on the unipodal balance test (54.2%, p = 0.001) and low mean grip strength (but only in men (p = 0.005)). They also showed some difficulties in daily life activities (climbing stairs, walking one block, both p<0.0001). Age ≥60 years (adjusted OR (aOR) = 3.4; CI95% = 1.9-5.9,), being a female (aOR = 2.1; CI95% = 1.1-4.1), having an abdominal obesity (aOR = 2.1; CI95% = 1.2-4.0), a longer duration of HIV infection (aOR = 2.9; CI95% = 1.5-5.7), old Nucleoside reverse transcriptase inhibitors (NRTIs) (i.e., AZT: zidovudine, ddI: didanosine, DDC: zalcitabine, D4T: stavudine) in current ART (aOR = 2.0 CI95% = 1.1-3.7) were associated with low SPPB performance. As in western countries, physical function limitation is now part of the burden of HIV disease complications of older PLHIV living in West Africa, putting this population at risk for disability. How to screen those impairments and integrate their management in the standards of care should be investigated, and specific research on developing adapted daily physical activity program might be conducted.Charlotte BernardHélène FontZélica DialloRichard AhononJudicaël Malick TineFranklin AbouoAristophane TanonEugène MessouMoussa SeydiFrançois DabisNathalie de RekeneireIeDEA West Africa Cohort CollaborationPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 15, Iss 10, p e0240906 (2020) |
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Medicine R Science Q |
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Medicine R Science Q Charlotte Bernard Hélène Font Zélica Diallo Richard Ahonon Judicaël Malick Tine Franklin Abouo Aristophane Tanon Eugène Messou Moussa Seydi François Dabis Nathalie de Rekeneire IeDEA West Africa Cohort Collaboration Prevalence and factors associated with physical function limitation in older West African people living with HIV. |
| description |
Although physical function decline is common with aging, the burden of this impairment remains underestimated in patients living with HIV (PLHIV), particularly in the older people receiving antiretroviral treatment (ART) and living in sub-Saharan Africa (SSA). PLHIV aged ≥50 years old and on ART since ≥6 months were included (N = 333) from three clinics (two in Côte d'Ivoire, one in Senegal) participating in the International epidemiological Databases to Evaluate AIDS (IeDEA) West Africa collaboration. Physical function was measured using the Short Physical Performance Battery (SPPB), the unipodal balance test and self-reported questionnaires. Grip strength was also assessed. Logistic regression was used to identify the factors associated with SPPB performance specifically. Median age was 57 (54-61) years, 57.7% were female and 82.7% had an undetectable viral load. The mean SPPB score was 10.2 ±1.8. Almost 30% had low SPPB performance with the 5-sit-to-stand test being the most altered subtest (64%). PLHIV with low SPPB performance also had significantly low performance on the unipodal balance test (54.2%, p = 0.001) and low mean grip strength (but only in men (p = 0.005)). They also showed some difficulties in daily life activities (climbing stairs, walking one block, both p<0.0001). Age ≥60 years (adjusted OR (aOR) = 3.4; CI95% = 1.9-5.9,), being a female (aOR = 2.1; CI95% = 1.1-4.1), having an abdominal obesity (aOR = 2.1; CI95% = 1.2-4.0), a longer duration of HIV infection (aOR = 2.9; CI95% = 1.5-5.7), old Nucleoside reverse transcriptase inhibitors (NRTIs) (i.e., AZT: zidovudine, ddI: didanosine, DDC: zalcitabine, D4T: stavudine) in current ART (aOR = 2.0 CI95% = 1.1-3.7) were associated with low SPPB performance. As in western countries, physical function limitation is now part of the burden of HIV disease complications of older PLHIV living in West Africa, putting this population at risk for disability. How to screen those impairments and integrate their management in the standards of care should be investigated, and specific research on developing adapted daily physical activity program might be conducted. |
| format |
article |
| author |
Charlotte Bernard Hélène Font Zélica Diallo Richard Ahonon Judicaël Malick Tine Franklin Abouo Aristophane Tanon Eugène Messou Moussa Seydi François Dabis Nathalie de Rekeneire IeDEA West Africa Cohort Collaboration |
| author_facet |
Charlotte Bernard Hélène Font Zélica Diallo Richard Ahonon Judicaël Malick Tine Franklin Abouo Aristophane Tanon Eugène Messou Moussa Seydi François Dabis Nathalie de Rekeneire IeDEA West Africa Cohort Collaboration |
| author_sort |
Charlotte Bernard |
| title |
Prevalence and factors associated with physical function limitation in older West African people living with HIV. |
| title_short |
Prevalence and factors associated with physical function limitation in older West African people living with HIV. |
| title_full |
Prevalence and factors associated with physical function limitation in older West African people living with HIV. |
| title_fullStr |
Prevalence and factors associated with physical function limitation in older West African people living with HIV. |
| title_full_unstemmed |
Prevalence and factors associated with physical function limitation in older West African people living with HIV. |
| title_sort |
prevalence and factors associated with physical function limitation in older west african people living with hiv. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2020 |
| url |
https://doaj.org/article/3f6ab9aeda2d449eb2e8885954eba6b6 |
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