Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

There are distinct hypermethylation patterns in gene promoters in hepatocellular carcinomas (HCCs). Here, the authors show that the enhancer of C/EBPβ is recurrently hypomethylated in human HCCs, recapitulating this in a transgenic murine model and linking aberrant enhancer hypomethylation to hepato...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Lei Xiong, Feng Wu, Qiong Wu, Liangliang Xu, Otto K. Cheung, Wei Kang, Myth T. Mok, Lemuel L. M. Szeto, Cheuk-Yin Lun, Raymond W. Lung, Jinglin Zhang, Ken H. Yu, Sau-Dan Lee, Guangcun Huang, Chiou-Miin Wang, Joseph Liu, Zhuo Yu, Dae-Yeul Yu, Jian-Liang Chou, Wan-Hong Huang, Bo Feng, Yue-Sun Cheung, Paul B. Lai, Patrick Tan, Nathalie Wong, Michael W. Chan, Tim H. Huang, Kevin Y. Yip, Alfred S. Cheng, Ka-Fai To
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3f6c3461a5c841138bb59978799a70b5
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:3f6c3461a5c841138bb59978799a70b5
record_format dspace
spelling oai:doaj.org-article:3f6c3461a5c841138bb59978799a70b52021-12-02T17:02:10ZAberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming10.1038/s41467-018-08245-z2041-1723https://doaj.org/article/3f6c3461a5c841138bb59978799a70b52019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08245-zhttps://doaj.org/toc/2041-1723There are distinct hypermethylation patterns in gene promoters in hepatocellular carcinomas (HCCs). Here, the authors show that the enhancer of C/EBPβ is recurrently hypomethylated in human HCCs, recapitulating this in a transgenic murine model and linking aberrant enhancer hypomethylation to hepatocarcinogenesis.Lei XiongFeng WuQiong WuLiangliang XuOtto K. CheungWei KangMyth T. MokLemuel L. M. SzetoCheuk-Yin LunRaymond W. LungJinglin ZhangKen H. YuSau-Dan LeeGuangcun HuangChiou-Miin WangJoseph LiuZhuo YuDae-Yeul YuJian-Liang ChouWan-Hong HuangBo FengYue-Sun CheungPaul B. LaiPatrick TanNathalie WongMichael W. ChanTim H. HuangKevin Y. YipAlfred S. ChengKa-Fai ToNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lei Xiong
Feng Wu
Qiong Wu
Liangliang Xu
Otto K. Cheung
Wei Kang
Myth T. Mok
Lemuel L. M. Szeto
Cheuk-Yin Lun
Raymond W. Lung
Jinglin Zhang
Ken H. Yu
Sau-Dan Lee
Guangcun Huang
Chiou-Miin Wang
Joseph Liu
Zhuo Yu
Dae-Yeul Yu
Jian-Liang Chou
Wan-Hong Huang
Bo Feng
Yue-Sun Cheung
Paul B. Lai
Patrick Tan
Nathalie Wong
Michael W. Chan
Tim H. Huang
Kevin Y. Yip
Alfred S. Cheng
Ka-Fai To
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
description There are distinct hypermethylation patterns in gene promoters in hepatocellular carcinomas (HCCs). Here, the authors show that the enhancer of C/EBPβ is recurrently hypomethylated in human HCCs, recapitulating this in a transgenic murine model and linking aberrant enhancer hypomethylation to hepatocarcinogenesis.
format article
author Lei Xiong
Feng Wu
Qiong Wu
Liangliang Xu
Otto K. Cheung
Wei Kang
Myth T. Mok
Lemuel L. M. Szeto
Cheuk-Yin Lun
Raymond W. Lung
Jinglin Zhang
Ken H. Yu
Sau-Dan Lee
Guangcun Huang
Chiou-Miin Wang
Joseph Liu
Zhuo Yu
Dae-Yeul Yu
Jian-Liang Chou
Wan-Hong Huang
Bo Feng
Yue-Sun Cheung
Paul B. Lai
Patrick Tan
Nathalie Wong
Michael W. Chan
Tim H. Huang
Kevin Y. Yip
Alfred S. Cheng
Ka-Fai To
author_facet Lei Xiong
Feng Wu
Qiong Wu
Liangliang Xu
Otto K. Cheung
Wei Kang
Myth T. Mok
Lemuel L. M. Szeto
Cheuk-Yin Lun
Raymond W. Lung
Jinglin Zhang
Ken H. Yu
Sau-Dan Lee
Guangcun Huang
Chiou-Miin Wang
Joseph Liu
Zhuo Yu
Dae-Yeul Yu
Jian-Liang Chou
Wan-Hong Huang
Bo Feng
Yue-Sun Cheung
Paul B. Lai
Patrick Tan
Nathalie Wong
Michael W. Chan
Tim H. Huang
Kevin Y. Yip
Alfred S. Cheng
Ka-Fai To
author_sort Lei Xiong
title Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
title_short Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
title_full Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
title_fullStr Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
title_full_unstemmed Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
title_sort aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/3f6c3461a5c841138bb59978799a70b5
work_keys_str_mv AT leixiong aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT fengwu aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT qiongwu aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT liangliangxu aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT ottokcheung aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT weikang aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT mythtmok aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT lemuellmszeto aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT cheukyinlun aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT raymondwlung aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT jinglinzhang aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT kenhyu aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT saudanlee aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT guangcunhuang aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT chioumiinwang aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT josephliu aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT zhuoyu aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT daeyeulyu aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT jianliangchou aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT wanhonghuang aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT bofeng aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT yuesuncheung aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT paulblai aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT patricktan aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT nathaliewong aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT michaelwchan aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT timhhuang aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT kevinyyip aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT alfredscheng aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
AT kafaito aberrantenhancerhypomethylationcontributestohepaticcarcinogenesisthroughglobaltranscriptionalreprogramming
_version_ 1718381962436018176

Ejemplares similares