CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS

Аbstract. The aim of present study was to investigate an influence of polyclonal activators upon cytokine-producing function of peripheral blood cells in the patients with colorectal adenocarcinomas. It was revealed that the stimulated production of IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whol...

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Autores principales:	A. V. Sosnina, A. I. Autenshlyus, N. V. Velikaya, N. A. Varaksin, M. Yu. Rukhavishnikov, E. S. Mikhailova, D. V. Morozov, S. A. Fursov, N. V. Agarina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cytokines polyclonal activators colorectal cancera Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/3f70631f593e47abb394e9ed784d1edf
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spelling	oai:doaj.org-article:3f70631f593e47abb394e9ed784d1edf2021-11-18T08:03:42ZCYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS1563-06252313-741X10.15789/1563-0625-2011-2-3-197-204https://doaj.org/article/3f70631f593e47abb394e9ed784d1edf2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/519https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XАbstract. The aim of present study was to investigate an influence of polyclonal activators upon cytokine-producing function of peripheral blood cells in the patients with colorectal adenocarcinomas. It was revealed that the stimulated production of IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whole blood cells treated with polyclonal activators was significantly decreased in colorectal cancer patients, as compared to healthy individuals. The stimulated IL-1ra and IL-17 production was depressed during the tumor progression, along with increased release of TNFα and IL-8. It was found that the stimulation index of polyclonal activators upon production of IL-17 by whole blood cells (i.e., a cytokine production ratio of stimulated versus resting cells) may be used as a reliable pre-surgery predictor of tumor invasion, the latter being an important histopathological parameter for clinical oncologists. (Med. Immunol., 2011, vol. 13, N 2-3, pp 197-204A. V. SosninaA. I. AutenshlyusN. V. VelikayaN. A. VaraksinM. Yu. RukhavishnikovE. S. MikhailovaD. V. MorozovS. A. FursovN. V. AgarinaSPb RAACIarticlecytokinespolyclonal activatorscolorectal canceraImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 197-204 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines polyclonal activators colorectal cancera Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines polyclonal activators colorectal cancera Immunologic diseases. Allergy RC581-607 A. V. Sosnina A. I. Autenshlyus N. V. Velikaya N. A. Varaksin M. Yu. Rukhavishnikov E. S. Mikhailova D. V. Morozov S. A. Fursov N. V. Agarina CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
description	Аbstract. The aim of present study was to investigate an influence of polyclonal activators upon cytokine-producing function of peripheral blood cells in the patients with colorectal adenocarcinomas. It was revealed that the stimulated production of IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whole blood cells treated with polyclonal activators was significantly decreased in colorectal cancer patients, as compared to healthy individuals. The stimulated IL-1ra and IL-17 production was depressed during the tumor progression, along with increased release of TNFα and IL-8. It was found that the stimulation index of polyclonal activators upon production of IL-17 by whole blood cells (i.e., a cytokine production ratio of stimulated versus resting cells) may be used as a reliable pre-surgery predictor of tumor invasion, the latter being an important histopathological parameter for clinical oncologists. (Med. Immunol., 2011, vol. 13, N 2-3, pp 197-204
format	article
author	A. V. Sosnina A. I. Autenshlyus N. V. Velikaya N. A. Varaksin M. Yu. Rukhavishnikov E. S. Mikhailova D. V. Morozov S. A. Fursov N. V. Agarina
author_facet	A. V. Sosnina A. I. Autenshlyus N. V. Velikaya N. A. Varaksin M. Yu. Rukhavishnikov E. S. Mikhailova D. V. Morozov S. A. Fursov N. V. Agarina
author_sort	A. V. Sosnina
title	CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
title_short	CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
title_full	CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
title_fullStr	CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
title_full_unstemmed	CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
title_sort	cytokine-producing function of peripheral blood cells in colorectal cancer patients
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/3f70631f593e47abb394e9ed784d1edf
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CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS

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