Green Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth

Stanley Chung,1,* Renhui Zhou,2,* Thomas J Webster1 1Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA; 2College of Chemistry, Nankai University, Tianjin 300071, People’s Republic of China*These authors contributed equally to this workCorrespondence: Thomas...

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Autores principales:	Chung S, Zhou R, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	selenium green synthesis nanoparticles antibacterial ascorbic acid Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3f726792780e4575accdd0dd3c3bfc7e
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spelling	oai:doaj.org-article:3f726792780e4575accdd0dd3c3bfc7e2021-12-02T04:16:17ZGreen Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth1178-2013https://doaj.org/article/3f726792780e4575accdd0dd3c3bfc7e2020-01-01T00:00:00Zhttps://www.dovepress.com/green-synthesized-bsa-coated-selenium-nanoparticles-inhibit-bacterial--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Stanley Chung,1,* Renhui Zhou,2,* Thomas J Webster1 1Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA; 2College of Chemistry, Nankai University, Tianjin 300071, People’s Republic of China*These authors contributed equally to this workCorrespondence: Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, 360 Huntington Avenue, 313 Snell Engineering Center, Boston, MA 02215, USAEmail th.webster@neu.eduBackground: Selenium is an essential trace element that is critical for many biological processes. Selenium nanoparticles (SeNPs) have shown more promise than other forms of selenium due to their low cytotoxicity and high bioavailability.Methods: In this work, a one-step method was demonstrated for fabricating bovine serum albumin (BSA) stabilized SeNPs using ascorbic acid as the reductant. Human dermal fibroblasts were used to assess mammalian cytotoxicity, and Staphylococcus aureus and Escherichia coli were used to assess antibacterial performance.Results: These SeNPs demonstrated increased fibroblast growth and reduced Staphylococcus aureus growth with a fibroblast IC50 value (>681 μg/mL) 1 order of magnitude higher than that for bacteria at day 1.Conclusion: This study demonstrated the promise of this synthesis process in achieving controllable selenium nanoparticle sizes without the use of strong basic solvents for improved antibacterial properties.Keywords: selenium, green synthesis, nanoparticles, antibacterial, ascorbic acidChung SZhou RWebster TJDove Medical Pressarticleseleniumgreen synthesisnanoparticlesantibacterialascorbic acidMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 115-124 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	selenium green synthesis nanoparticles antibacterial ascorbic acid Medicine (General) R5-920
spellingShingle	selenium green synthesis nanoparticles antibacterial ascorbic acid Medicine (General) R5-920 Chung S Zhou R Webster TJ Green Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth
description	Stanley Chung,1,* Renhui Zhou,2,* Thomas J Webster1 1Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA; 2College of Chemistry, Nankai University, Tianjin 300071, People’s Republic of China*These authors contributed equally to this workCorrespondence: Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, 360 Huntington Avenue, 313 Snell Engineering Center, Boston, MA 02215, USAEmail th.webster@neu.eduBackground: Selenium is an essential trace element that is critical for many biological processes. Selenium nanoparticles (SeNPs) have shown more promise than other forms of selenium due to their low cytotoxicity and high bioavailability.Methods: In this work, a one-step method was demonstrated for fabricating bovine serum albumin (BSA) stabilized SeNPs using ascorbic acid as the reductant. Human dermal fibroblasts were used to assess mammalian cytotoxicity, and Staphylococcus aureus and Escherichia coli were used to assess antibacterial performance.Results: These SeNPs demonstrated increased fibroblast growth and reduced Staphylococcus aureus growth with a fibroblast IC50 value (>681 μg/mL) 1 order of magnitude higher than that for bacteria at day 1.Conclusion: This study demonstrated the promise of this synthesis process in achieving controllable selenium nanoparticle sizes without the use of strong basic solvents for improved antibacterial properties.Keywords: selenium, green synthesis, nanoparticles, antibacterial, ascorbic acid
format	article
author	Chung S Zhou R Webster TJ
author_facet	Chung S Zhou R Webster TJ
author_sort	Chung S
title	Green Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth
title_short	Green Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth
title_full	Green Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth
title_fullStr	Green Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth
title_full_unstemmed	Green Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth
title_sort	green synthesized bsa-coated selenium nanoparticles inhibit bacterial growth while promoting mammalian cell growth
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/3f726792780e4575accdd0dd3c3bfc7e
work_keys_str_mv	AT chungs greensynthesizedbsacoatedseleniumnanoparticlesinhibitbacterialgrowthwhilepromotingmammaliancellgrowth AT zhour greensynthesizedbsacoatedseleniumnanoparticlesinhibitbacterialgrowthwhilepromotingmammaliancellgrowth AT webstertj greensynthesizedbsacoatedseleniumnanoparticlesinhibitbacterialgrowthwhilepromotingmammaliancellgrowth
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Green Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth

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