PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells

T cells are involved in the bone loss induced by parathyroid hormone (PTH), but their origin is unknown. Here, the authors show that the intestinal microbiota is required for PTH to induce bone loss and describes mechanisms for microbiota-mediated gut–bone crosstalk in mouse models of hyperparathyro...

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Autores principales:	Mingcan Yu, Abdul Malik Tyagi, Jau-Yi Li, Jonathan Adams, Timothy L. Denning, M. Neale Weitzmann, Rheinallt M. Jones, Roberto Pacifici
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f73e1cc8c504ed8ad4787bd0c1d7608
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spelling	oai:doaj.org-article:3f73e1cc8c504ed8ad4787bd0c1d76082021-12-02T15:39:21ZPTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells10.1038/s41467-019-14148-42041-1723https://doaj.org/article/3f73e1cc8c504ed8ad4787bd0c1d76082020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14148-4https://doaj.org/toc/2041-1723T cells are involved in the bone loss induced by parathyroid hormone (PTH), but their origin is unknown. Here, the authors show that the intestinal microbiota is required for PTH to induce bone loss and describes mechanisms for microbiota-mediated gut–bone crosstalk in mouse models of hyperparathyroidism.Mingcan YuAbdul Malik TyagiJau-Yi LiJonathan AdamsTimothy L. DenningM. Neale WeitzmannRheinallt M. JonesRoberto PacificiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mingcan Yu Abdul Malik Tyagi Jau-Yi Li Jonathan Adams Timothy L. Denning M. Neale Weitzmann Rheinallt M. Jones Roberto Pacifici PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells
description	T cells are involved in the bone loss induced by parathyroid hormone (PTH), but their origin is unknown. Here, the authors show that the intestinal microbiota is required for PTH to induce bone loss and describes mechanisms for microbiota-mediated gut–bone crosstalk in mouse models of hyperparathyroidism.
format	article
author	Mingcan Yu Abdul Malik Tyagi Jau-Yi Li Jonathan Adams Timothy L. Denning M. Neale Weitzmann Rheinallt M. Jones Roberto Pacifici
author_facet	Mingcan Yu Abdul Malik Tyagi Jau-Yi Li Jonathan Adams Timothy L. Denning M. Neale Weitzmann Rheinallt M. Jones Roberto Pacifici
author_sort	Mingcan Yu
title	PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells
title_short	PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells
title_full	PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells
title_fullStr	PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells
title_full_unstemmed	PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells
title_sort	pth induces bone loss via microbial-dependent expansion of intestinal tnf+ t cells and th17 cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3f73e1cc8c504ed8ad4787bd0c1d7608
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PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells

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