Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis

The primary cilium is essential for embryonic development and tissue pattern formation. Here the authors show that PIPKIγ localizes to the basal body of the primary cilium and cooperates with the Joubert Syndrome associated protein INPP5E to regulate the initiation of ciliogenesis.

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Autores principales: Qingwen Xu, Yuxia Zhang, Qing Wei, Yan Huang, Jinghua Hu, Kun Ling
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/3f77dcf03e1344ef8597e1062395d441
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spelling oai:doaj.org-article:3f77dcf03e1344ef8597e1062395d4412021-12-02T15:33:50ZPhosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis10.1038/ncomms107772041-1723https://doaj.org/article/3f77dcf03e1344ef8597e1062395d4412016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10777https://doaj.org/toc/2041-1723The primary cilium is essential for embryonic development and tissue pattern formation. Here the authors show that PIPKIγ localizes to the basal body of the primary cilium and cooperates with the Joubert Syndrome associated protein INPP5E to regulate the initiation of ciliogenesis.Qingwen XuYuxia ZhangQing WeiYan HuangJinghua HuKun LingNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qingwen Xu
Yuxia Zhang
Qing Wei
Yan Huang
Jinghua Hu
Kun Ling
Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis
description The primary cilium is essential for embryonic development and tissue pattern formation. Here the authors show that PIPKIγ localizes to the basal body of the primary cilium and cooperates with the Joubert Syndrome associated protein INPP5E to regulate the initiation of ciliogenesis.
format article
author Qingwen Xu
Yuxia Zhang
Qing Wei
Yan Huang
Jinghua Hu
Kun Ling
author_facet Qingwen Xu
Yuxia Zhang
Qing Wei
Yan Huang
Jinghua Hu
Kun Ling
author_sort Qingwen Xu
title Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis
title_short Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis
title_full Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis
title_fullStr Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis
title_full_unstemmed Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis
title_sort phosphatidylinositol phosphate kinase pipkiγ and phosphatase inpp5e coordinate initiation of ciliogenesis
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/3f77dcf03e1344ef8597e1062395d441
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AT yuxiazhang phosphatidylinositolphosphatekinasepipkigandphosphataseinpp5ecoordinateinitiationofciliogenesis
AT qingwei phosphatidylinositolphosphatekinasepipkigandphosphataseinpp5ecoordinateinitiationofciliogenesis
AT yanhuang phosphatidylinositolphosphatekinasepipkigandphosphataseinpp5ecoordinateinitiationofciliogenesis
AT jinghuahu phosphatidylinositolphosphatekinasepipkigandphosphataseinpp5ecoordinateinitiationofciliogenesis
AT kunling phosphatidylinositolphosphatekinasepipkigandphosphataseinpp5ecoordinateinitiationofciliogenesis
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