CORRECTION OF INTERFERON-α-INDUCED DENDRITIC CELL DYSFUNCTIONS IN IMMUNOCOMPROMISED PATIENTS

The correction of impaired functions of in vitro generated interferon-alpha-induced dendritic cells (IFN-DCs) in patients with malignant brain tumors (n = 8), malignant lymphomas (n = 14) and pulmonary tuberculosis (n = 26) was analyzed in the present study. The principal possibility of restoring re...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	O. Yu. Leplina, L. V. Sakhno, A. A. Ostanin, S. S. Bogachev, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	dendritic cells interferon-alpha correction cytotoxicity allostimulatory activity Science Q
Acceso en línea:	https://doaj.org/article/3f78891c3b9b421d8fda264799976e3c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3f78891c3b9b421d8fda264799976e3c
record_format	dspace
spelling	oai:doaj.org-article:3f78891c3b9b421d8fda264799976e3c2021-11-23T06:14:19ZCORRECTION OF INTERFERON-α-INDUCED DENDRITIC CELL DYSFUNCTIONS IN IMMUNOCOMPROMISED PATIENTS2541-94202587-9596https://doaj.org/article/3f78891c3b9b421d8fda264799976e3c2012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/896https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The correction of impaired functions of in vitro generated interferon-alpha-induced dendritic cells (IFN-DCs) in patients with malignant brain tumors (n = 8), malignant lymphomas (n = 14) and pulmonary tuberculosis (n = 26) was analyzed in the present study. The principal possibility of restoring reduced functional activity of patient DCs was shown. The addition of recombinant human IL-2, complex of pro-inflammatory cytokines, double-stranded human DNA or polyoxidonium to IFN-DC cultures at the stage of maturation could significantly increase the allostimulatory activity of DCs in patients with malignant lymphomas and pulmonary tuberculosis, as well as enhance the cytotoxic activity of cancer patient DCs against NK- and TRAIL-resistant tumor cell line HEp-2. These findings offer new approaches to the correction of DC dysfunctions in the pathology and justify ways of improving the treatment of infectious diseases and cancer using dendritic cell vaccines.O. Yu. LeplinaL. V. SakhnoA. A. OstaninS. S. BogachevE. R. ChernykhScientific Сentre for Family Health and Human Reproduction Problemsarticledendritic cellsinterferon-alphacorrectioncytotoxicityallostimulatory activityScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 104-108 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	dendritic cells interferon-alpha correction cytotoxicity allostimulatory activity Science Q
spellingShingle	dendritic cells interferon-alpha correction cytotoxicity allostimulatory activity Science Q O. Yu. Leplina L. V. Sakhno A. A. Ostanin S. S. Bogachev E. R. Chernykh CORRECTION OF INTERFERON-α-INDUCED DENDRITIC CELL DYSFUNCTIONS IN IMMUNOCOMPROMISED PATIENTS
description	The correction of impaired functions of in vitro generated interferon-alpha-induced dendritic cells (IFN-DCs) in patients with malignant brain tumors (n = 8), malignant lymphomas (n = 14) and pulmonary tuberculosis (n = 26) was analyzed in the present study. The principal possibility of restoring reduced functional activity of patient DCs was shown. The addition of recombinant human IL-2, complex of pro-inflammatory cytokines, double-stranded human DNA or polyoxidonium to IFN-DC cultures at the stage of maturation could significantly increase the allostimulatory activity of DCs in patients with malignant lymphomas and pulmonary tuberculosis, as well as enhance the cytotoxic activity of cancer patient DCs against NK- and TRAIL-resistant tumor cell line HEp-2. These findings offer new approaches to the correction of DC dysfunctions in the pathology and justify ways of improving the treatment of infectious diseases and cancer using dendritic cell vaccines.
format	article
author	O. Yu. Leplina L. V. Sakhno A. A. Ostanin S. S. Bogachev E. R. Chernykh
author_facet	O. Yu. Leplina L. V. Sakhno A. A. Ostanin S. S. Bogachev E. R. Chernykh
author_sort	O. Yu. Leplina
title	CORRECTION OF INTERFERON-α-INDUCED DENDRITIC CELL DYSFUNCTIONS IN IMMUNOCOMPROMISED PATIENTS
title_short	CORRECTION OF INTERFERON-α-INDUCED DENDRITIC CELL DYSFUNCTIONS IN IMMUNOCOMPROMISED PATIENTS
title_full	CORRECTION OF INTERFERON-α-INDUCED DENDRITIC CELL DYSFUNCTIONS IN IMMUNOCOMPROMISED PATIENTS
title_fullStr	CORRECTION OF INTERFERON-α-INDUCED DENDRITIC CELL DYSFUNCTIONS IN IMMUNOCOMPROMISED PATIENTS
title_full_unstemmed	CORRECTION OF INTERFERON-α-INDUCED DENDRITIC CELL DYSFUNCTIONS IN IMMUNOCOMPROMISED PATIENTS
title_sort	correction of interferon-α-induced dendritic cell dysfunctions in immunocompromised patients
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/3f78891c3b9b421d8fda264799976e3c
work_keys_str_mv	AT oyuleplina correctionofinterferonainduceddendriticcelldysfunctionsinimmunocompromisedpatients AT lvsakhno correctionofinterferonainduceddendriticcelldysfunctionsinimmunocompromisedpatients AT aaostanin correctionofinterferonainduceddendriticcelldysfunctionsinimmunocompromisedpatients AT ssbogachev correctionofinterferonainduceddendriticcelldysfunctionsinimmunocompromisedpatients AT erchernykh correctionofinterferonainduceddendriticcelldysfunctionsinimmunocompromisedpatients
_version_	1718417313461436416

CORRECTION OF INTERFERON-α-INDUCED DENDRITIC CELL DYSFUNCTIONS IN IMMUNOCOMPROMISED PATIENTS

Ejemplares similares