Liposomal formulation of vitamin A for the potential treatment of osteoporosis

Jainy Sachaniya, Reema Savaliya, Ramesh Goyal, Sanjay Singh Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Vitamin A targeting to bones is a suitable treatment for osteoporosis. In this study, we have developed vitamin A-enca...

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Autores principales:	Sachaniya J, Savaliya R, Goyal R, Singh S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Liposome Vitamin A Osteoporosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3f7d77a3646946b2963a977563884595
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spelling	oai:doaj.org-article:3f7d77a3646946b2963a9775638845952021-12-02T00:48:21ZLiposomal formulation of vitamin A for the potential treatment of osteoporosis1178-2013https://doaj.org/article/3f7d77a3646946b2963a9775638845952018-03-01T00:00:00Zhttps://www.dovepress.com/liposomal-formulation-of-vitamin-a-for-the-potential-treatment-of-oste-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jainy Sachaniya, Reema Savaliya, Ramesh Goyal, Sanjay Singh Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Vitamin A targeting to bones is a suitable treatment for osteoporosis. In this study, we have developed vitamin A-encapsulated liposomes that can be useful to deliver vitamin A to the bones in a selective manner. This liposomal formulation of vitamin A has been found to be stable for >6 months as no significant change in size and charge occurred. Vitamin A liposomes-induced cell proliferation in SaOS-2 (human osteosarcoma cell line) and release kinetics study concluded that the liposomal formulation of vitamin A gives a controlled release of vitamin A in comparison to the free vitamin. The MTT assay showed the proliferation of SaOS-2 cells after their treatment with vitamin A liposomes. Keywords: SaOS-2, nanoliposomes, osteoporosisSachaniya JSavaliya RGoyal RSingh SDove Medical PressarticleLiposomeVitamin AOsteoporosisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 51-53 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Liposome Vitamin A Osteoporosis Medicine (General) R5-920
spellingShingle	Liposome Vitamin A Osteoporosis Medicine (General) R5-920 Sachaniya J Savaliya R Goyal R Singh S Liposomal formulation of vitamin A for the potential treatment of osteoporosis
description	Jainy Sachaniya, Reema Savaliya, Ramesh Goyal, Sanjay Singh Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Vitamin A targeting to bones is a suitable treatment for osteoporosis. In this study, we have developed vitamin A-encapsulated liposomes that can be useful to deliver vitamin A to the bones in a selective manner. This liposomal formulation of vitamin A has been found to be stable for >6 months as no significant change in size and charge occurred. Vitamin A liposomes-induced cell proliferation in SaOS-2 (human osteosarcoma cell line) and release kinetics study concluded that the liposomal formulation of vitamin A gives a controlled release of vitamin A in comparison to the free vitamin. The MTT assay showed the proliferation of SaOS-2 cells after their treatment with vitamin A liposomes. Keywords: SaOS-2, nanoliposomes, osteoporosis
format	article
author	Sachaniya J Savaliya R Goyal R Singh S
author_facet	Sachaniya J Savaliya R Goyal R Singh S
author_sort	Sachaniya J
title	Liposomal formulation of vitamin A for the potential treatment of osteoporosis
title_short	Liposomal formulation of vitamin A for the potential treatment of osteoporosis
title_full	Liposomal formulation of vitamin A for the potential treatment of osteoporosis
title_fullStr	Liposomal formulation of vitamin A for the potential treatment of osteoporosis
title_full_unstemmed	Liposomal formulation of vitamin A for the potential treatment of osteoporosis
title_sort	liposomal formulation of vitamin a for the potential treatment of osteoporosis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3f7d77a3646946b2963a977563884595
work_keys_str_mv	AT sachaniyaj liposomalformulationofvitaminaforthepotentialtreatmentofosteoporosis AT savaliyar liposomalformulationofvitaminaforthepotentialtreatmentofosteoporosis AT goyalr liposomalformulationofvitaminaforthepotentialtreatmentofosteoporosis AT singhs liposomalformulationofvitaminaforthepotentialtreatmentofosteoporosis
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Liposomal formulation of vitamin A for the potential treatment of osteoporosis

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