Gender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast Chinese children health study.

<h4>Background</h4>Males and females exhibit different health responses to air pollution, but little is known about how exposure to air pollution affects juvenile respiratory health after analysis stratified by allergic predisposition. The aim of the present study was to assess the relat...

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Autores principales:	Guang-Hui Dong, Tao Chen, Miao-Miao Liu, Da Wang, Ya-Nan Ma, Wan-Hui Ren, Yungling Leo Lee, Ya-Dong Zhao, Qin-Cheng He
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f7e1543869542ffb79a67caf541252e
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spelling	oai:doaj.org-article:3f7e1543869542ffb79a67caf541252e2021-11-18T06:50:00ZGender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast Chinese children health study.1932-620310.1371/journal.pone.0022470https://doaj.org/article/3f7e1543869542ffb79a67caf541252e2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21811617/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Males and females exhibit different health responses to air pollution, but little is known about how exposure to air pollution affects juvenile respiratory health after analysis stratified by allergic predisposition. The aim of the present study was to assess the relationship between air pollutants and asthmatic symptoms in Chinese children selected from multiple sites in a heavily industrialized province of China, and investigate whether allergic predisposition modifies this relationship.<h4>Methodology/principal findings</h4>30139 Chinese children aged 3-to-12 years were selected from 25 districts of seven cities in northeast China in 2009. Information on respiratory health was obtained using a standard questionnaire from the American Thoracic Society. Routine air-pollution monitoring data was used for particles with an aerodynamic diameter ≤10 µm (PM(10)), sulfur dioxide (SO(2)), nitrogen dioxides (NO(2)), ozone (O(3)) and carbon monoxide (CO). A two-stage regression approach was applied in data analyses. The effect estimates were presented as odds ratios (ORs) per interquartile changes for PM(10), SO(2), NO(2), O(3), and CO. The results showed that children with allergic predisposition were more susceptible to air pollutants than children without allergic predisposition. Amongst children without an allergic predisposition, air pollution effects on asthma were stronger in males compared to females; Current asthma prevalence was related to PM(10) (ORs = 1.36 per 31 µg/m(3); 95% CI, 1.08-1.72), SO(2) (ORs = 1.38 per 21 µg/m(3); 95%CI, 1.12-1.69) only among males. However, among children with allergic predisposition, more positively associations between air pollutants and respiratory symptoms and diseases were detected in females; An increased prevalence of doctor-diagnosed asthma was significantly associated with SO(2) (ORs = 1.48 per 21 µg/m(3); 95%CI, 1.21-1.80), NO(2) (ORs = 1.26 per 10 µg/m(3); 95%CI, 1.01-1.56), and current asthma with O(3) (ORs = 1.55 per 23 µg/m(3); 95%CI, 1.18-2.04) only among females.<h4>Conclusion/significance</h4>Ambient air pollutions were more evident in males without an allergic predisposition and more associations were detected in females with allergic predisposition.Guang-Hui DongTao ChenMiao-Miao LiuDa WangYa-Nan MaWan-Hui RenYungling Leo LeeYa-Dong ZhaoQin-Cheng HePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22470 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guang-Hui Dong Tao Chen Miao-Miao Liu Da Wang Ya-Nan Ma Wan-Hui Ren Yungling Leo Lee Ya-Dong Zhao Qin-Cheng He Gender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast Chinese children health study.
description	<h4>Background</h4>Males and females exhibit different health responses to air pollution, but little is known about how exposure to air pollution affects juvenile respiratory health after analysis stratified by allergic predisposition. The aim of the present study was to assess the relationship between air pollutants and asthmatic symptoms in Chinese children selected from multiple sites in a heavily industrialized province of China, and investigate whether allergic predisposition modifies this relationship.<h4>Methodology/principal findings</h4>30139 Chinese children aged 3-to-12 years were selected from 25 districts of seven cities in northeast China in 2009. Information on respiratory health was obtained using a standard questionnaire from the American Thoracic Society. Routine air-pollution monitoring data was used for particles with an aerodynamic diameter ≤10 µm (PM(10)), sulfur dioxide (SO(2)), nitrogen dioxides (NO(2)), ozone (O(3)) and carbon monoxide (CO). A two-stage regression approach was applied in data analyses. The effect estimates were presented as odds ratios (ORs) per interquartile changes for PM(10), SO(2), NO(2), O(3), and CO. The results showed that children with allergic predisposition were more susceptible to air pollutants than children without allergic predisposition. Amongst children without an allergic predisposition, air pollution effects on asthma were stronger in males compared to females; Current asthma prevalence was related to PM(10) (ORs = 1.36 per 31 µg/m(3); 95% CI, 1.08-1.72), SO(2) (ORs = 1.38 per 21 µg/m(3); 95%CI, 1.12-1.69) only among males. However, among children with allergic predisposition, more positively associations between air pollutants and respiratory symptoms and diseases were detected in females; An increased prevalence of doctor-diagnosed asthma was significantly associated with SO(2) (ORs = 1.48 per 21 µg/m(3); 95%CI, 1.21-1.80), NO(2) (ORs = 1.26 per 10 µg/m(3); 95%CI, 1.01-1.56), and current asthma with O(3) (ORs = 1.55 per 23 µg/m(3); 95%CI, 1.18-2.04) only among females.<h4>Conclusion/significance</h4>Ambient air pollutions were more evident in males without an allergic predisposition and more associations were detected in females with allergic predisposition.
format	article
author	Guang-Hui Dong Tao Chen Miao-Miao Liu Da Wang Ya-Nan Ma Wan-Hui Ren Yungling Leo Lee Ya-Dong Zhao Qin-Cheng He
author_facet	Guang-Hui Dong Tao Chen Miao-Miao Liu Da Wang Ya-Nan Ma Wan-Hui Ren Yungling Leo Lee Ya-Dong Zhao Qin-Cheng He
author_sort	Guang-Hui Dong
title	Gender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast Chinese children health study.
title_short	Gender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast Chinese children health study.
title_full	Gender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast Chinese children health study.
title_fullStr	Gender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast Chinese children health study.
title_full_unstemmed	Gender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast Chinese children health study.
title_sort	gender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast chinese children health study.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/3f7e1543869542ffb79a67caf541252e
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Gender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast Chinese children health study.

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