YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation

Relapse is a limitation for the efficacy of the anaplastic lymphoma kinase (ALK)-inhibitor alectinib in ALK-rearranged lung cancer. Here, the authors show that YAP1 activation upon alectinib treatment leads to therapy resistance and that inhibiting both YAP1 and ALK leads to longer tumor remission i...

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Autores principales:	Takahiro Tsuji, Hiroaki Ozasa, Wataru Aoki, Shunsuke Aburaya, Tomoko Yamamoto Funazo, Koh Furugaki, Yasushi Yoshimura, Masatoshi Yamazoe, Hitomi Ajimizu, Yuto Yasuda, Takashi Nomizo, Hironori Yoshida, Yuichi Sakamori, Hiroaki Wake, Mitsuyoshi Ueda, Young Hak Kim, Toyohiro Hirai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f80ddddea7640be87705e31f5e46a2a
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spelling	oai:doaj.org-article:3f80ddddea7640be87705e31f5e46a2a2021-12-02T14:41:15ZYAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation10.1038/s41467-019-13771-52041-1723https://doaj.org/article/3f80ddddea7640be87705e31f5e46a2a2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13771-5https://doaj.org/toc/2041-1723Relapse is a limitation for the efficacy of the anaplastic lymphoma kinase (ALK)-inhibitor alectinib in ALK-rearranged lung cancer. Here, the authors show that YAP1 activation upon alectinib treatment leads to therapy resistance and that inhibiting both YAP1 and ALK leads to longer tumor remission in mice.Takahiro TsujiHiroaki OzasaWataru AokiShunsuke AburayaTomoko Yamamoto FunazoKoh FurugakiYasushi YoshimuraMasatoshi YamazoeHitomi AjimizuYuto YasudaTakashi NomizoHironori YoshidaYuichi SakamoriHiroaki WakeMitsuyoshi UedaYoung Hak KimToyohiro HiraiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takahiro Tsuji Hiroaki Ozasa Wataru Aoki Shunsuke Aburaya Tomoko Yamamoto Funazo Koh Furugaki Yasushi Yoshimura Masatoshi Yamazoe Hitomi Ajimizu Yuto Yasuda Takashi Nomizo Hironori Yoshida Yuichi Sakamori Hiroaki Wake Mitsuyoshi Ueda Young Hak Kim Toyohiro Hirai YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation
description	Relapse is a limitation for the efficacy of the anaplastic lymphoma kinase (ALK)-inhibitor alectinib in ALK-rearranged lung cancer. Here, the authors show that YAP1 activation upon alectinib treatment leads to therapy resistance and that inhibiting both YAP1 and ALK leads to longer tumor remission in mice.
format	article
author	Takahiro Tsuji Hiroaki Ozasa Wataru Aoki Shunsuke Aburaya Tomoko Yamamoto Funazo Koh Furugaki Yasushi Yoshimura Masatoshi Yamazoe Hitomi Ajimizu Yuto Yasuda Takashi Nomizo Hironori Yoshida Yuichi Sakamori Hiroaki Wake Mitsuyoshi Ueda Young Hak Kim Toyohiro Hirai
author_facet	Takahiro Tsuji Hiroaki Ozasa Wataru Aoki Shunsuke Aburaya Tomoko Yamamoto Funazo Koh Furugaki Yasushi Yoshimura Masatoshi Yamazoe Hitomi Ajimizu Yuto Yasuda Takashi Nomizo Hironori Yoshida Yuichi Sakamori Hiroaki Wake Mitsuyoshi Ueda Young Hak Kim Toyohiro Hirai
author_sort	Takahiro Tsuji
title	YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation
title_short	YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation
title_full	YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation
title_fullStr	YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation
title_full_unstemmed	YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation
title_sort	yap1 mediates survival of alk-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3f80ddddea7640be87705e31f5e46a2a
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YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation

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