Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications

Marina Kalomiraki,1 Kyriaki Thermos,2 Nikos A Chaniotakis1 1Laboratory of Analytical Chemistry, Department of Chemistry, 2Department of Pharmacology, School of Medicine, University of Crete Voutes, Heraklion, Greece Abstract: Dendrimers are large polymeric structures with nanosize dimension...

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Autores principales:	Kalomiraki M, Thermos K, Chaniotakis NA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	nanoparticles ocular encapsulation delivery dendrimers Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3f81786824e84ed9bd1818c0075b2481
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spelling	oai:doaj.org-article:3f81786824e84ed9bd1818c0075b24812021-12-02T02:52:22ZDendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications1178-2013https://doaj.org/article/3f81786824e84ed9bd1818c0075b24812015-12-01T00:00:00Zhttps://www.dovepress.com/dendrimers-as-tunable-vectors-of-drug-delivery-systems-and-biomedical--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Marina Kalomiraki,1 Kyriaki Thermos,2 Nikos A Chaniotakis1 1Laboratory of Analytical Chemistry, Department of Chemistry, 2Department of Pharmacology, School of Medicine, University of Crete Voutes, Heraklion, Greece Abstract: Dendrimers are large polymeric structures with nanosize dimensions (1–10 nm) and unique physicochemical properties. The major advantage of dendrimers compared with linear polymers is their spherical-shaped structure. During synthesis, the size and shape of the dendrimer can be customized and controlled, so the finished macromolecule will have a specific “architecture” and terminal groups. These characteristics will determine its suitability for drug delivery, diagnostic imaging, and as a genetic material carrier. This review will focus initially on the unique properties of dendrimers and their use in biomedical applications, as antibacterial, antitumor, and diagnostic agents. Subsequently, emphasis will be given to their use in drug delivery for ocular diseases. Keywords: nanoparticles, ocular diseases, encapsulation, macromolecule, diagnostic agentKalomiraki MThermos KChaniotakis NADove Medical PressarticlenanoparticlesocularencapsulationdeliverydendrimersMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss Issue 1, Pp 1-12 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticles ocular encapsulation delivery dendrimers Medicine (General) R5-920
spellingShingle	nanoparticles ocular encapsulation delivery dendrimers Medicine (General) R5-920 Kalomiraki M Thermos K Chaniotakis NA Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications
description	Marina Kalomiraki,1 Kyriaki Thermos,2 Nikos A Chaniotakis1 1Laboratory of Analytical Chemistry, Department of Chemistry, 2Department of Pharmacology, School of Medicine, University of Crete Voutes, Heraklion, Greece Abstract: Dendrimers are large polymeric structures with nanosize dimensions (1–10 nm) and unique physicochemical properties. The major advantage of dendrimers compared with linear polymers is their spherical-shaped structure. During synthesis, the size and shape of the dendrimer can be customized and controlled, so the finished macromolecule will have a specific “architecture” and terminal groups. These characteristics will determine its suitability for drug delivery, diagnostic imaging, and as a genetic material carrier. This review will focus initially on the unique properties of dendrimers and their use in biomedical applications, as antibacterial, antitumor, and diagnostic agents. Subsequently, emphasis will be given to their use in drug delivery for ocular diseases. Keywords: nanoparticles, ocular diseases, encapsulation, macromolecule, diagnostic agent
format	article
author	Kalomiraki M Thermos K Chaniotakis NA
author_facet	Kalomiraki M Thermos K Chaniotakis NA
author_sort	Kalomiraki M
title	Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications
title_short	Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications
title_full	Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications
title_fullStr	Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications
title_full_unstemmed	Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications
title_sort	dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/3f81786824e84ed9bd1818c0075b2481
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_version_	1718402096802299904

Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications

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