Comparison Between The Efficacy of Fentanyl Continuous Infusion and Intratechal Morphine for Pain After Cesarean Section

Background: Intrathecal morphine has been shown to be effective for pain after cesarean section with possible side effect including delayed respiratory depression, nausea vomiting and pruritus. Fentanyl continuous infusion fixed base infusion rate with disposable elastomeric pump is an alternative t...

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Autores principales:	Prabowo Wicaksono Yuwono Putro, Taufiqurrachman Nasihun
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2018
Materias:	pain caesarean section intrathecal morphine fentanyl continuous infusion disposable elastomeric pump nrs ooaps cortisol Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3f82fc02a2b14a37b15ce311672b2294
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spelling	oai:doaj.org-article:3f82fc02a2b14a37b15ce311672b22942021-11-25T13:15:53ZComparison Between The Efficacy of Fentanyl Continuous Infusion and Intratechal Morphine for Pain After Cesarean Section2085-15452339-093X10.26532/sainsmed.v8i2.1842https://doaj.org/article/3f82fc02a2b14a37b15ce311672b22942018-04-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/1842https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XBackground: Intrathecal morphine has been shown to be effective for pain after cesarean section with possible side effect including delayed respiratory depression, nausea vomiting and pruritus. Fentanyl continuous infusion fixed base infusion rate with disposable elastomeric pump is an alternative to intrathecal morphine but has not been been widely studied. Objective: to compare the effectiveness between fentanyl continuous infusion fixed base infusion rate using disposable elastomeric pump and intrathecal morphine. Methods: in a Randomized Controlled Trial (RCT), 56 patients meeting the inclusion criteria were divided into two groups: Morphine group (n=28): spinal anesthesia 10 mg Bupivacaine Heavy 0.5% + 100 mcg morphine; Fentanyl group (n=28): spinal anesthesia 10 mg Bupivacaine Heavy 0.5% + fentanyl continuous infusion 0.5 mcg/kg BW/hour using disposable elastomeric pump after delivery. Data analysis: Mann-Whitney test at the level of significance p<0.05. Results: Analgesic effect of Fentanyl group was as effective as that of Morphine group. NRS score difference was significant only in measurement taken 6 hours after surgery (p=0.034). Mean NRS score for Morphine and Fentanyl were 68±1.02 and 1.11±0.832, respectively. Both group were effective in preventing increased cortisol level measured 6 hours after surgery, mean value group Morphine and Fentanyl were 15.053±8.664 and12.162±8.623, respectively.There were no statistical significant difference between groups (p=0.114). No significant difference in side effect between the groups was found. Conclusion: Fentanyl continuous infusion 0.5 mcg/kg BW/hour using disposable elastomeric pump is as effective as intrathecal morphine 100 mcg/kg BW/hourPrabowo Wicaksono Yuwono PutroTaufiqurrachman NasihunUniversitas Sultan Agung Semarangarticlepaincaesarean sectionintrathecal morphinefentanyl continuous infusiondisposable elastomeric pumpnrsooapscortisolMedicine (General)R5-920ENSains Medika, Vol 8, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	pain caesarean section intrathecal morphine fentanyl continuous infusion disposable elastomeric pump nrs ooaps cortisol Medicine (General) R5-920
spellingShingle	pain caesarean section intrathecal morphine fentanyl continuous infusion disposable elastomeric pump nrs ooaps cortisol Medicine (General) R5-920 Prabowo Wicaksono Yuwono Putro Taufiqurrachman Nasihun Comparison Between The Efficacy of Fentanyl Continuous Infusion and Intratechal Morphine for Pain After Cesarean Section
description	Background: Intrathecal morphine has been shown to be effective for pain after cesarean section with possible side effect including delayed respiratory depression, nausea vomiting and pruritus. Fentanyl continuous infusion fixed base infusion rate with disposable elastomeric pump is an alternative to intrathecal morphine but has not been been widely studied. Objective: to compare the effectiveness between fentanyl continuous infusion fixed base infusion rate using disposable elastomeric pump and intrathecal morphine. Methods: in a Randomized Controlled Trial (RCT), 56 patients meeting the inclusion criteria were divided into two groups: Morphine group (n=28): spinal anesthesia 10 mg Bupivacaine Heavy 0.5% + 100 mcg morphine; Fentanyl group (n=28): spinal anesthesia 10 mg Bupivacaine Heavy 0.5% + fentanyl continuous infusion 0.5 mcg/kg BW/hour using disposable elastomeric pump after delivery. Data analysis: Mann-Whitney test at the level of significance p<0.05. Results: Analgesic effect of Fentanyl group was as effective as that of Morphine group. NRS score difference was significant only in measurement taken 6 hours after surgery (p=0.034). Mean NRS score for Morphine and Fentanyl were 68±1.02 and 1.11±0.832, respectively. Both group were effective in preventing increased cortisol level measured 6 hours after surgery, mean value group Morphine and Fentanyl were 15.053±8.664 and12.162±8.623, respectively.There were no statistical significant difference between groups (p=0.114). No significant difference in side effect between the groups was found. Conclusion: Fentanyl continuous infusion 0.5 mcg/kg BW/hour using disposable elastomeric pump is as effective as intrathecal morphine 100 mcg/kg BW/hour
format	article
author	Prabowo Wicaksono Yuwono Putro Taufiqurrachman Nasihun
author_facet	Prabowo Wicaksono Yuwono Putro Taufiqurrachman Nasihun
author_sort	Prabowo Wicaksono Yuwono Putro
title	Comparison Between The Efficacy of Fentanyl Continuous Infusion and Intratechal Morphine for Pain After Cesarean Section
title_short	Comparison Between The Efficacy of Fentanyl Continuous Infusion and Intratechal Morphine for Pain After Cesarean Section
title_full	Comparison Between The Efficacy of Fentanyl Continuous Infusion and Intratechal Morphine for Pain After Cesarean Section
title_fullStr	Comparison Between The Efficacy of Fentanyl Continuous Infusion and Intratechal Morphine for Pain After Cesarean Section
title_full_unstemmed	Comparison Between The Efficacy of Fentanyl Continuous Infusion and Intratechal Morphine for Pain After Cesarean Section
title_sort	comparison between the efficacy of fentanyl continuous infusion and intratechal morphine for pain after cesarean section
publisher	Universitas Sultan Agung Semarang
publishDate	2018
url	https://doaj.org/article/3f82fc02a2b14a37b15ce311672b2294
work_keys_str_mv	AT prabowowicaksonoyuwonoputro comparisonbetweentheefficacyoffentanylcontinuousinfusionandintratechalmorphineforpainaftercesareansection AT taufiqurrachmannasihun comparisonbetweentheefficacyoffentanylcontinuousinfusionandintratechalmorphineforpainaftercesareansection
_version_	1718413491767869440

Comparison Between The Efficacy of Fentanyl Continuous Infusion and Intratechal Morphine for Pain After Cesarean Section

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