Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription

The antibiotic rifampicin inhibits transcription by targeting RpoB, a bacterial RNA polymerase subunit. Here, Zhu et al. show that certain cells in mycobacterial populations can continue to grow and divide in the presence of rifampicin due, paradoxically, to rifampicin-induced upregulation of the rp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jun-Hao Zhu, Bi-Wei Wang, Miaomiao Pan, Yu-Na Zeng, Hesper Rego, Babak Javid
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f840e4535144eccb7fec2628a4d3ff8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3f840e4535144eccb7fec2628a4d3ff8
record_format	dspace
spelling	oai:doaj.org-article:3f840e4535144eccb7fec2628a4d3ff82021-12-02T17:31:17ZRifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription10.1038/s41467-018-06667-32041-1723https://doaj.org/article/3f840e4535144eccb7fec2628a4d3ff82018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06667-3https://doaj.org/toc/2041-1723The antibiotic rifampicin inhibits transcription by targeting RpoB, a bacterial RNA polymerase subunit. Here, Zhu et al. show that certain cells in mycobacterial populations can continue to grow and divide in the presence of rifampicin due, paradoxically, to rifampicin-induced upregulation of the rpoB gene.Jun-Hao ZhuBi-Wei WangMiaomiao PanYu-Na ZengHesper RegoBabak JavidNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jun-Hao Zhu Bi-Wei Wang Miaomiao Pan Yu-Na Zeng Hesper Rego Babak Javid Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription
description	The antibiotic rifampicin inhibits transcription by targeting RpoB, a bacterial RNA polymerase subunit. Here, Zhu et al. show that certain cells in mycobacterial populations can continue to grow and divide in the presence of rifampicin due, paradoxically, to rifampicin-induced upregulation of the rpoB gene.
format	article
author	Jun-Hao Zhu Bi-Wei Wang Miaomiao Pan Yu-Na Zeng Hesper Rego Babak Javid
author_facet	Jun-Hao Zhu Bi-Wei Wang Miaomiao Pan Yu-Na Zeng Hesper Rego Babak Javid
author_sort	Jun-Hao Zhu
title	Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription
title_short	Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription
title_full	Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription
title_fullStr	Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription
title_full_unstemmed	Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription
title_sort	rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpob transcription
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3f840e4535144eccb7fec2628a4d3ff8
work_keys_str_mv	AT junhaozhu rifampicincaninduceantibiotictoleranceinmycobacteriaviaparadoxicalchangesinrpobtranscription AT biweiwang rifampicincaninduceantibiotictoleranceinmycobacteriaviaparadoxicalchangesinrpobtranscription AT miaomiaopan rifampicincaninduceantibiotictoleranceinmycobacteriaviaparadoxicalchangesinrpobtranscription AT yunazeng rifampicincaninduceantibiotictoleranceinmycobacteriaviaparadoxicalchangesinrpobtranscription AT hesperrego rifampicincaninduceantibiotictoleranceinmycobacteriaviaparadoxicalchangesinrpobtranscription AT babakjavid rifampicincaninduceantibiotictoleranceinmycobacteriaviaparadoxicalchangesinrpobtranscription
_version_	1718380668595994624

Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription

Ejemplares similares