The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy

Junyu Deng,1 Ye Liu,1 Yiqiu Liu,1 Wei Li,1,2 Xuqiang Nie1– 4 1College of Pharmacy, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 2Joint International Research Laboratory of Ethnomedicine of Chinese Ministry of Education, Zunyi Medical University, Zunyi, 563000, People’s Republ...

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Autores principales:	Deng J, Liu Y, Li W, Nie X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	fibroblast growth factor diabetic nephropathy signaling pathways pharmacological action renal fibrosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3f88572e43d34505b3fb5060f20cb095
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spelling	oai:doaj.org-article:3f88572e43d34505b3fb5060f20cb0952021-12-02T19:21:04ZThe Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy1178-7031https://doaj.org/article/3f88572e43d34505b3fb5060f20cb0952021-10-01T00:00:00Zhttps://www.dovepress.com/the-multiple-roles-of-fibroblast-growth-factor-in-diabetic-nephropathy-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Junyu Deng,1 Ye Liu,1 Yiqiu Liu,1 Wei Li,1,2 Xuqiang Nie1– 4 1College of Pharmacy, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 2Joint International Research Laboratory of Ethnomedicine of Chinese Ministry of Education, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 3Key Laboratory of the Basic Pharmacology of the Ministry of Education, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 4Institute of Materia Medica, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing, 400038, People’s Republic of ChinaCorrespondence: Xuqiang NieCollege of Pharmacy, Joint International Research Laboratory of Ethnomedicine of Chinese Ministry of Education, Zunyi Medical University, Zunyi, 563000, People’s Republic of ChinaTel +86-0851-2864-2516Email niexuqiang@zmu.edu.cnAbstract: Diabetic nephropathy (DN) is a common microvascular complication in the late stages of diabetes. Currently, the etiology and pathogenesis of DN are not well understood. Even so, available evidence shows its development is associated with metabolism, oxidative stress, cytokine interaction, genetic factors, and renal microvascular disease. Diabetic nephropathy can lead to proteinuria, edema and hypertension, among other complications. In severe cases, it can cause life-threatening complications such as renal failure. Patients with type 1 diabetes, hypertension, high protein intake, and smokers have a higher risk of developing DN. Fibroblast growth factor (FGF) regulates several human processes essential for normal development. Even though FGF has been implicated in the pathological development of DN, the underlying mechanisms are not well understood. This review summarizes the role of FGF in the development of DN. Moreover, the association of FGF with metabolism, inflammation, oxidative stress and fibrosis in the context of DN is discussed. Findings of this review are expected to deepen our understanding of DN and generate ideas for developing effective prevention and treatments for the disease.Keywords: fibroblast growth factor, diabetic nephropathy, signaling pathways, pharmacological action, renal fibrosisDeng JLiu YLiu YLi WNie XDove Medical Pressarticlefibroblast growth factordiabetic nephropathysignaling pathwayspharmacological actionrenal fibrosisPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5273-5290 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fibroblast growth factor diabetic nephropathy signaling pathways pharmacological action renal fibrosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	fibroblast growth factor diabetic nephropathy signaling pathways pharmacological action renal fibrosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Deng J Liu Y Liu Y Li W Nie X The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy
description	Junyu Deng,1 Ye Liu,1 Yiqiu Liu,1 Wei Li,1,2 Xuqiang Nie1– 4 1College of Pharmacy, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 2Joint International Research Laboratory of Ethnomedicine of Chinese Ministry of Education, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 3Key Laboratory of the Basic Pharmacology of the Ministry of Education, Zunyi Medical University, Zunyi, 563000, People’s Republic of China; 4Institute of Materia Medica, College of Pharmacy, Third Military Medical University (Army Medical University), Chongqing, 400038, People’s Republic of ChinaCorrespondence: Xuqiang NieCollege of Pharmacy, Joint International Research Laboratory of Ethnomedicine of Chinese Ministry of Education, Zunyi Medical University, Zunyi, 563000, People’s Republic of ChinaTel +86-0851-2864-2516Email niexuqiang@zmu.edu.cnAbstract: Diabetic nephropathy (DN) is a common microvascular complication in the late stages of diabetes. Currently, the etiology and pathogenesis of DN are not well understood. Even so, available evidence shows its development is associated with metabolism, oxidative stress, cytokine interaction, genetic factors, and renal microvascular disease. Diabetic nephropathy can lead to proteinuria, edema and hypertension, among other complications. In severe cases, it can cause life-threatening complications such as renal failure. Patients with type 1 diabetes, hypertension, high protein intake, and smokers have a higher risk of developing DN. Fibroblast growth factor (FGF) regulates several human processes essential for normal development. Even though FGF has been implicated in the pathological development of DN, the underlying mechanisms are not well understood. This review summarizes the role of FGF in the development of DN. Moreover, the association of FGF with metabolism, inflammation, oxidative stress and fibrosis in the context of DN is discussed. Findings of this review are expected to deepen our understanding of DN and generate ideas for developing effective prevention and treatments for the disease.Keywords: fibroblast growth factor, diabetic nephropathy, signaling pathways, pharmacological action, renal fibrosis
format	article
author	Deng J Liu Y Liu Y Li W Nie X
author_facet	Deng J Liu Y Liu Y Li W Nie X
author_sort	Deng J
title	The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy
title_short	The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy
title_full	The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy
title_fullStr	The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy
title_full_unstemmed	The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy
title_sort	multiple roles of fibroblast growth factor in diabetic nephropathy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/3f88572e43d34505b3fb5060f20cb095
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The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy

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