Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions

We provide the data on distribution of IL-1β and IL-1ra cytokine concentrations in nasal secretions from the patients with different forms of chronic polypous rhinosinusitis. The control group (group 1) included healthy persons. The second group consisted of patients exhibiting chronic polypous rhin...

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Autores principales:	E. V. Bezrukova, E. V. Vorobeychikov, V. G. Konusova, A. S. Simbirtsev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	chronic rhinosinusitis nasal polyposis il-1β il-1ra cytokines interleukins Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/3f89fa194ded492bb1cbe05d6359285f
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spelling	oai:doaj.org-article:3f89fa194ded492bb1cbe05d6359285f2021-11-18T08:03:49ZSeverity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions1563-06252313-741X10.15789/1563-0625-2019-6-1155-1162https://doaj.org/article/3f89fa194ded492bb1cbe05d6359285f2020-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1742https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe provide the data on distribution of IL-1β and IL-1ra cytokine concentrations in nasal secretions from the patients with different forms of chronic polypous rhinosinusitis. The control group (group 1) included healthy persons. The second group consisted of patients exhibiting chronic polypous rhinosinusitis (CRS-NP), free of clinical signs of purulent inflammation in paranasal sinuses and/or bronchial asthma. The patients of group 3 were diagnosed with chronic purulent polypous rhinosinusitis (CPRS-NP). Group 4 consisted of the patients with chronic polypoid rhinosinusitis complicated by bronchial asthma (CRS-NP + BA). Cytokine concentration was determined by means of ELISA tests for all the patient groups. We have found that the local concentrations of IL-1ra and IL-1β cytokines were significantly different (p < 0.05) from the group of healthy individuals, dependent on the clinical forms of chronic polyposis. IL-1β concentrations in the group of patients with CRS-NP (No. 2) were increased 5-fold, for group of CPRS-NP patients (No. 3), these levels showed a 15.5-fold increase. In the group of patients with CRS-NP + BA (No. 4), the Il-1 levels were 13fold higher in comparison with healthy controls. The IL-1ra concentration in the group of healthy people (No. 1) was 1825.64+463.70 pg/ml. Upon development of CRS-NP (No. 2), an increase in its values up to 3646.21±263.39 pg/ml was registered. Upon development of CPRS-NP (No. 3), an increase in appropriate values up to 2305.33±282.86 pg/ml was noted, and, in cases of CRS-NP + BA, a decrease in its values to 956.15±213.02 pg/ml was observed.Meanwhile, a conflicting character was revealed for the changes in these cytokines, thus preventing their usage as an indicator of polyposis severity. At the same time, estimation of the CIL-1ra/CIL- 1β ratio in nasal secretions of the patients in groups 1, 2, 3 and 4 based on two-dimensional projection of the spatial CIL-1ra/ CIL-1β distribution provides a basis for discrimination of the patient groups. The CIL-1ra/ CIL-1β ratio as assessed for nasal secretions of patients belonging to groups 1, 2, 3, and 4 shows a general, statistically significant decrease with increasing severity of chronic polyposis (p < 0.001), thus making this parameter indiformative for intensity of the pathological process. The resulting 95% confidence intervals confirm that the cytokine ratios are promising parameter in order to estimate the efficiency of immune therapy.E. V. BezrukovaE. V. VorobeychikovV. G. KonusovaA. S. SimbirtsevSPb RAACIarticlechronic rhinosinusitisnasal polyposisil-1βil-1racytokineschronic rhinosinusitisinterleukinsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 6, Pp 1155-1162 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic rhinosinusitis nasal polyposis il-1β il-1ra cytokines chronic rhinosinusitis interleukins Immunologic diseases. Allergy RC581-607
spellingShingle	chronic rhinosinusitis nasal polyposis il-1β il-1ra cytokines chronic rhinosinusitis interleukins Immunologic diseases. Allergy RC581-607 E. V. Bezrukova E. V. Vorobeychikov V. G. Konusova A. S. Simbirtsev Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions
description	We provide the data on distribution of IL-1β and IL-1ra cytokine concentrations in nasal secretions from the patients with different forms of chronic polypous rhinosinusitis. The control group (group 1) included healthy persons. The second group consisted of patients exhibiting chronic polypous rhinosinusitis (CRS-NP), free of clinical signs of purulent inflammation in paranasal sinuses and/or bronchial asthma. The patients of group 3 were diagnosed with chronic purulent polypous rhinosinusitis (CPRS-NP). Group 4 consisted of the patients with chronic polypoid rhinosinusitis complicated by bronchial asthma (CRS-NP + BA). Cytokine concentration was determined by means of ELISA tests for all the patient groups. We have found that the local concentrations of IL-1ra and IL-1β cytokines were significantly different (p < 0.05) from the group of healthy individuals, dependent on the clinical forms of chronic polyposis. IL-1β concentrations in the group of patients with CRS-NP (No. 2) were increased 5-fold, for group of CPRS-NP patients (No. 3), these levels showed a 15.5-fold increase. In the group of patients with CRS-NP + BA (No. 4), the Il-1 levels were 13fold higher in comparison with healthy controls. The IL-1ra concentration in the group of healthy people (No. 1) was 1825.64+463.70 pg/ml. Upon development of CRS-NP (No. 2), an increase in its values up to 3646.21±263.39 pg/ml was registered. Upon development of CPRS-NP (No. 3), an increase in appropriate values up to 2305.33±282.86 pg/ml was noted, and, in cases of CRS-NP + BA, a decrease in its values to 956.15±213.02 pg/ml was observed.Meanwhile, a conflicting character was revealed for the changes in these cytokines, thus preventing their usage as an indicator of polyposis severity. At the same time, estimation of the CIL-1ra/CIL- 1β ratio in nasal secretions of the patients in groups 1, 2, 3 and 4 based on two-dimensional projection of the spatial CIL-1ra/ CIL-1β distribution provides a basis for discrimination of the patient groups. The CIL-1ra/ CIL-1β ratio as assessed for nasal secretions of patients belonging to groups 1, 2, 3, and 4 shows a general, statistically significant decrease with increasing severity of chronic polyposis (p < 0.001), thus making this parameter indiformative for intensity of the pathological process. The resulting 95% confidence intervals confirm that the cytokine ratios are promising parameter in order to estimate the efficiency of immune therapy.
format	article
author	E. V. Bezrukova E. V. Vorobeychikov V. G. Konusova A. S. Simbirtsev
author_facet	E. V. Bezrukova E. V. Vorobeychikov V. G. Konusova A. S. Simbirtsev
author_sort	E. V. Bezrukova
title	Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions
title_short	Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions
title_full	Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions
title_fullStr	Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions
title_full_unstemmed	Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions
title_sort	severity evaluation of bhronic polypous rhinosinusitis based on changes of il-1β cytokine and il-1ra concentrations in nasal secretions
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/3f89fa194ded492bb1cbe05d6359285f
work_keys_str_mv	AT evbezrukova severityevaluationofbhronicpolypousrhinosinusitisbasedonchangesofil1bcytokineandil1raconcentrationsinnasalsecretions AT evvorobeychikov severityevaluationofbhronicpolypousrhinosinusitisbasedonchangesofil1bcytokineandil1raconcentrationsinnasalsecretions AT vgkonusova severityevaluationofbhronicpolypousrhinosinusitisbasedonchangesofil1bcytokineandil1raconcentrationsinnasalsecretions AT assimbirtsev severityevaluationofbhronicpolypousrhinosinusitisbasedonchangesofil1bcytokineandil1raconcentrationsinnasalsecretions
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Severity evaluation of bhronic polypous rhinosinusitis based on changes of IL-1β cytokine and IL-1ra concentrations in nasal secretions

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