Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles

Cristiana Maria Grapa,1,* Teodora Mocan,1,2,* Diana Gonciar,1,3,* Claudiu Zdrehus,1,3,* Ofelia Mosteanu,1,3,* Teodora Pop,1,* Lucian Mocan1,3,* 1Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology “Prof. Dr. Octavian Fodor”, Cluj-Napoca, Romania; 2Physi...

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Autores principales:	Grapa CM, Mocan T, Gonciar D, Zdrehus C, Mosteanu O, Pop T, Mocan L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	pancreatic adenocarcinoma egfr nanoparticles targeted therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3f8a3b047a084c8f9ddbf344801204d9
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spelling	oai:doaj.org-article:3f8a3b047a084c8f9ddbf344801204d92021-12-02T05:28:22ZEpidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles1178-2013https://doaj.org/article/3f8a3b047a084c8f9ddbf344801204d92019-12-01T00:00:00Zhttps://www.dovepress.com/epidermal-growth-factor-receptor-and-its-role-in-pancreatic-cancer-tre-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Cristiana Maria Grapa,1,* Teodora Mocan,1,2,* Diana Gonciar,1,3,* Claudiu Zdrehus,1,3,* Ofelia Mosteanu,1,3,* Teodora Pop,1,* Lucian Mocan1,3,* 1Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology “Prof. Dr. Octavian Fodor”, Cluj-Napoca, Romania; 2Physiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; 33rd Surgery Clinic, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania*All authors contributed equally to this workCorrespondence: Teodora MocanPhysiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 1 Clinicilor Street, Cluj-Napoca 40006, RomaniaTel +40264598575Fax +40264599814Email teodora.mocan@umfcluj.roAbstract: Pancreatic adenocarcinoma (PDAC) is a disease with a high incidence and a dreary prognosis. Its lack of symptomatology and late diagnosis contribute to the dearth and inefficiency of therapeutic schemes. Studies show that overexpressed epidermal growth factor receptor (EGFR) is a common occurrence, linking this to the progression of pancreatic cancer, although the association between its expression and the survival rate is rather controversial. EGFR-targeted therapy has not shown the results expected, leaving at hand more questions than answers; clearly, there is a need for a better understanding of the molecular pathways involved. Nanoparticles have been used in trying to improve the efficacy of antitumor treatment; thus, using EGFR’s ligand, EGF, for nanoconjugation, showed promising results in increasing the cellular uptake mechanisms and apoptosis of the targeted cells.Keywords: pancreatic adenocarcinoma, EGFR, nanoparticles, targeted therapyGrapa CMMocan TGonciar DZdrehus CMosteanu OPop TMocan LDove Medical Pressarticlepancreatic adenocarcinomaegfrnanoparticlestargeted therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 9693-9706 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	pancreatic adenocarcinoma egfr nanoparticles targeted therapy Medicine (General) R5-920
spellingShingle	pancreatic adenocarcinoma egfr nanoparticles targeted therapy Medicine (General) R5-920 Grapa CM Mocan T Gonciar D Zdrehus C Mosteanu O Pop T Mocan L Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles
description	Cristiana Maria Grapa,1,* Teodora Mocan,1,2,* Diana Gonciar,1,3,* Claudiu Zdrehus,1,3,* Ofelia Mosteanu,1,3,* Teodora Pop,1,* Lucian Mocan1,3,* 1Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology “Prof. Dr. Octavian Fodor”, Cluj-Napoca, Romania; 2Physiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; 33rd Surgery Clinic, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania*All authors contributed equally to this workCorrespondence: Teodora MocanPhysiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 1 Clinicilor Street, Cluj-Napoca 40006, RomaniaTel +40264598575Fax +40264599814Email teodora.mocan@umfcluj.roAbstract: Pancreatic adenocarcinoma (PDAC) is a disease with a high incidence and a dreary prognosis. Its lack of symptomatology and late diagnosis contribute to the dearth and inefficiency of therapeutic schemes. Studies show that overexpressed epidermal growth factor receptor (EGFR) is a common occurrence, linking this to the progression of pancreatic cancer, although the association between its expression and the survival rate is rather controversial. EGFR-targeted therapy has not shown the results expected, leaving at hand more questions than answers; clearly, there is a need for a better understanding of the molecular pathways involved. Nanoparticles have been used in trying to improve the efficacy of antitumor treatment; thus, using EGFR’s ligand, EGF, for nanoconjugation, showed promising results in increasing the cellular uptake mechanisms and apoptosis of the targeted cells.Keywords: pancreatic adenocarcinoma, EGFR, nanoparticles, targeted therapy
format	article
author	Grapa CM Mocan T Gonciar D Zdrehus C Mosteanu O Pop T Mocan L
author_facet	Grapa CM Mocan T Gonciar D Zdrehus C Mosteanu O Pop T Mocan L
author_sort	Grapa CM
title	Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles
title_short	Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles
title_full	Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles
title_fullStr	Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles
title_full_unstemmed	Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles
title_sort	epidermal growth factor receptor and its role in pancreatic cancer treatment mediated by nanoparticles
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/3f8a3b047a084c8f9ddbf344801204d9
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Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles

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