Integrative biology defines novel biomarkers of resistance to strongylid infection in horses

Abstract The widespread failure of anthelmintic drugs against nematodes of veterinary interest requires novel control strategies. Selective treatment of the most susceptible individuals could reduce drug selection pressure but requires appropriate biomarkers of the intrinsic susceptibility potential...

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Autores principales:	Guillaume Sallé, Cécile Canlet, Jacques Cortet, Christine Koch, Joshua Malsa, Fabrice Reigner, Mickaël Riou, Noémie Perrot, Alexandra Blanchard, Núria Mach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f8af32fb6fe499282d5c8a15d7e2ae7
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spelling	oai:doaj.org-article:3f8af32fb6fe499282d5c8a15d7e2ae72021-12-02T18:30:50ZIntegrative biology defines novel biomarkers of resistance to strongylid infection in horses10.1038/s41598-021-93468-22045-2322https://doaj.org/article/3f8af32fb6fe499282d5c8a15d7e2ae72021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93468-2https://doaj.org/toc/2045-2322Abstract The widespread failure of anthelmintic drugs against nematodes of veterinary interest requires novel control strategies. Selective treatment of the most susceptible individuals could reduce drug selection pressure but requires appropriate biomarkers of the intrinsic susceptibility potential. To date, this has been missing in livestock species. Here, we selected Welsh ponies with divergent intrinsic susceptibility (measured by their egg excretion levels) to cyathostomin infection and found that their divergence was sustained across a 10-year time window. Using this unique set of individuals, we monitored variations in their blood cell populations, plasma metabolites and faecal microbiota over a grazing season to isolate core differences between their respective responses under worm-free or natural infection conditions. Our analyses identified the concomitant rise in plasma phenylalanine level and faecal Prevotella abundance and the reduction in circulating monocyte counts as biomarkers of the need for drug treatment (egg excretion above 200 eggs/g). This biological signal was replicated in other independent populations. We also unravelled an immunometabolic network encompassing plasma beta-hydroxybutyrate level, short-chain fatty acid producing bacteria and circulating neutrophils that forms the discriminant baseline between susceptible and resistant individuals. Altogether our observations open new perspectives on the susceptibility of equids to strongylid infection and leave scope for both new biomarkers of infection and nutritional intervention.Guillaume SalléCécile CanletJacques CortetChristine KochJoshua MalsaFabrice ReignerMickaël RiouNoémie PerrotAlexandra BlanchardNúria MachNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guillaume Sallé Cécile Canlet Jacques Cortet Christine Koch Joshua Malsa Fabrice Reigner Mickaël Riou Noémie Perrot Alexandra Blanchard Núria Mach Integrative biology defines novel biomarkers of resistance to strongylid infection in horses
description	Abstract The widespread failure of anthelmintic drugs against nematodes of veterinary interest requires novel control strategies. Selective treatment of the most susceptible individuals could reduce drug selection pressure but requires appropriate biomarkers of the intrinsic susceptibility potential. To date, this has been missing in livestock species. Here, we selected Welsh ponies with divergent intrinsic susceptibility (measured by their egg excretion levels) to cyathostomin infection and found that their divergence was sustained across a 10-year time window. Using this unique set of individuals, we monitored variations in their blood cell populations, plasma metabolites and faecal microbiota over a grazing season to isolate core differences between their respective responses under worm-free or natural infection conditions. Our analyses identified the concomitant rise in plasma phenylalanine level and faecal Prevotella abundance and the reduction in circulating monocyte counts as biomarkers of the need for drug treatment (egg excretion above 200 eggs/g). This biological signal was replicated in other independent populations. We also unravelled an immunometabolic network encompassing plasma beta-hydroxybutyrate level, short-chain fatty acid producing bacteria and circulating neutrophils that forms the discriminant baseline between susceptible and resistant individuals. Altogether our observations open new perspectives on the susceptibility of equids to strongylid infection and leave scope for both new biomarkers of infection and nutritional intervention.
format	article
author	Guillaume Sallé Cécile Canlet Jacques Cortet Christine Koch Joshua Malsa Fabrice Reigner Mickaël Riou Noémie Perrot Alexandra Blanchard Núria Mach
author_facet	Guillaume Sallé Cécile Canlet Jacques Cortet Christine Koch Joshua Malsa Fabrice Reigner Mickaël Riou Noémie Perrot Alexandra Blanchard Núria Mach
author_sort	Guillaume Sallé
title	Integrative biology defines novel biomarkers of resistance to strongylid infection in horses
title_short	Integrative biology defines novel biomarkers of resistance to strongylid infection in horses
title_full	Integrative biology defines novel biomarkers of resistance to strongylid infection in horses
title_fullStr	Integrative biology defines novel biomarkers of resistance to strongylid infection in horses
title_full_unstemmed	Integrative biology defines novel biomarkers of resistance to strongylid infection in horses
title_sort	integrative biology defines novel biomarkers of resistance to strongylid infection in horses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3f8af32fb6fe499282d5c8a15d7e2ae7
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Integrative biology defines novel biomarkers of resistance to strongylid infection in horses

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