Effect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index

Abstract Among women undergoing IVF, high BMI negatively affects pregnancy outcomes when using the conventional ovary stimulating protocols combined with fresh embryo transfer. Therefore, finding a proper treatment for these high BMI women is more important and urgent when obesity is prevalent. In o...

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Autores principales:	Li Wang, Mingru Yin, Yali Liu, Qiuju Chen, Yun Wang, Ai Ai, Yonglun Fu, Zhiguang Yan, Wei Jin, Hui Long, Qifeng Lyu, Yanping Kuang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f8af44ae1d84f93ae9fd372de3c8f37
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spelling	oai:doaj.org-article:3f8af44ae1d84f93ae9fd372de3c8f372021-12-02T11:52:39ZEffect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index10.1038/s41598-017-07773-w2045-2322https://doaj.org/article/3f8af44ae1d84f93ae9fd372de3c8f372017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07773-whttps://doaj.org/toc/2045-2322Abstract Among women undergoing IVF, high BMI negatively affects pregnancy outcomes when using the conventional ovary stimulating protocols combined with fresh embryo transfer. Therefore, finding a proper treatment for these high BMI women is more important and urgent when obesity is prevalent. In our study, we reported a retrospective study of 4457 women who were divided into normal BMI group (18.5 kg/m2–24.9 kg/m2) and high BMI group (≥25 kg/m2) undergoing 4611 IVF treatment cycles with frozen embryo transfer (FET). We found the high BMI group originally had the poor oocytes performance, but after FET they got the similar pregnancy outcomes as the normal BMI group. Then under FET we analyzed the IVF outcomes of our new progestin-primed ovary stimulation (PPOS) protocol, indicating that the hMG + MPA (4 or 10 mg/d) groups had the obvious better pregnancy results than the conventional short group in the high BMI group, and binary logistic regression analysis showed the hMG + MPA (10 mg/d) group was associated with better pregnancy outcomes than the hMG + MPA (4 mg/d) group. These results indicate PPOS - hMG + MPA (10 mg/d) combined with FET might be a new potential treatment choice for the high BMI women undergoing IVF treatments.Li WangMingru YinYali LiuQiuju ChenYun WangAi AiYonglun FuZhiguang YanWei JinHui LongQifeng LyuYanping KuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li Wang Mingru Yin Yali Liu Qiuju Chen Yun Wang Ai Ai Yonglun Fu Zhiguang Yan Wei Jin Hui Long Qifeng Lyu Yanping Kuang Effect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index
description	Abstract Among women undergoing IVF, high BMI negatively affects pregnancy outcomes when using the conventional ovary stimulating protocols combined with fresh embryo transfer. Therefore, finding a proper treatment for these high BMI women is more important and urgent when obesity is prevalent. In our study, we reported a retrospective study of 4457 women who were divided into normal BMI group (18.5 kg/m2–24.9 kg/m2) and high BMI group (≥25 kg/m2) undergoing 4611 IVF treatment cycles with frozen embryo transfer (FET). We found the high BMI group originally had the poor oocytes performance, but after FET they got the similar pregnancy outcomes as the normal BMI group. Then under FET we analyzed the IVF outcomes of our new progestin-primed ovary stimulation (PPOS) protocol, indicating that the hMG + MPA (4 or 10 mg/d) groups had the obvious better pregnancy results than the conventional short group in the high BMI group, and binary logistic regression analysis showed the hMG + MPA (10 mg/d) group was associated with better pregnancy outcomes than the hMG + MPA (4 mg/d) group. These results indicate PPOS - hMG + MPA (10 mg/d) combined with FET might be a new potential treatment choice for the high BMI women undergoing IVF treatments.
format	article
author	Li Wang Mingru Yin Yali Liu Qiuju Chen Yun Wang Ai Ai Yonglun Fu Zhiguang Yan Wei Jin Hui Long Qifeng Lyu Yanping Kuang
author_facet	Li Wang Mingru Yin Yali Liu Qiuju Chen Yun Wang Ai Ai Yonglun Fu Zhiguang Yan Wei Jin Hui Long Qifeng Lyu Yanping Kuang
author_sort	Li Wang
title	Effect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index
title_short	Effect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index
title_full	Effect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index
title_fullStr	Effect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index
title_full_unstemmed	Effect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index
title_sort	effect of frozen embryo transfer and progestin-primed ovary stimulation on ivf outcomes in women with high body mass index
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3f8af44ae1d84f93ae9fd372de3c8f37
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Effect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index

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