Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids

The mechanism of action of daptomycin, a lipopeptidic antibiotic, is unclear. Here, the authors show that Ca2+-daptomycin simultaneously interacts with lipid-coupled precursors of the bacterial cell envelope and with the anionic phospholipid phosphatidylglycerol, forming a tripartite complex.

Guardado en:

Detalles Bibliográficos
Autores principales:	Fabian Grein, Anna Müller, Katharina M. Scherer, Xinliang Liu, Kevin C. Ludwig, Anna Klöckner, Manuel Strach, Hans-Georg Sahl, Ulrich Kubitscheck, Tanja Schneider
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f8afa07193d465fb47aa48692257131
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3f8afa07193d465fb47aa48692257131
record_format	dspace
spelling	oai:doaj.org-article:3f8afa07193d465fb47aa486922571312021-12-02T14:40:29ZCa2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids10.1038/s41467-020-15257-12041-1723https://doaj.org/article/3f8afa07193d465fb47aa486922571312020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15257-1https://doaj.org/toc/2041-1723The mechanism of action of daptomycin, a lipopeptidic antibiotic, is unclear. Here, the authors show that Ca2+-daptomycin simultaneously interacts with lipid-coupled precursors of the bacterial cell envelope and with the anionic phospholipid phosphatidylglycerol, forming a tripartite complex.Fabian GreinAnna MüllerKatharina M. SchererXinliang LiuKevin C. LudwigAnna KlöcknerManuel StrachHans-Georg SahlUlrich KubitscheckTanja SchneiderNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabian Grein Anna Müller Katharina M. Scherer Xinliang Liu Kevin C. Ludwig Anna Klöckner Manuel Strach Hans-Georg Sahl Ulrich Kubitscheck Tanja Schneider Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
description	The mechanism of action of daptomycin, a lipopeptidic antibiotic, is unclear. Here, the authors show that Ca2+-daptomycin simultaneously interacts with lipid-coupled precursors of the bacterial cell envelope and with the anionic phospholipid phosphatidylglycerol, forming a tripartite complex.
format	article
author	Fabian Grein Anna Müller Katharina M. Scherer Xinliang Liu Kevin C. Ludwig Anna Klöckner Manuel Strach Hans-Georg Sahl Ulrich Kubitscheck Tanja Schneider
author_facet	Fabian Grein Anna Müller Katharina M. Scherer Xinliang Liu Kevin C. Ludwig Anna Klöckner Manuel Strach Hans-Georg Sahl Ulrich Kubitscheck Tanja Schneider
author_sort	Fabian Grein
title	Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
title_short	Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
title_full	Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
title_fullStr	Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
title_full_unstemmed	Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
title_sort	ca2+-daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3f8afa07193d465fb47aa48692257131
work_keys_str_mv	AT fabiangrein ca2daptomycintargetscellwallbiosynthesisbyformingatripartitecomplexwithundecaprenylcoupledintermediatesandmembranelipids AT annamuller ca2daptomycintargetscellwallbiosynthesisbyformingatripartitecomplexwithundecaprenylcoupledintermediatesandmembranelipids AT katharinamscherer ca2daptomycintargetscellwallbiosynthesisbyformingatripartitecomplexwithundecaprenylcoupledintermediatesandmembranelipids AT xinliangliu ca2daptomycintargetscellwallbiosynthesisbyformingatripartitecomplexwithundecaprenylcoupledintermediatesandmembranelipids AT kevincludwig ca2daptomycintargetscellwallbiosynthesisbyformingatripartitecomplexwithundecaprenylcoupledintermediatesandmembranelipids AT annaklockner ca2daptomycintargetscellwallbiosynthesisbyformingatripartitecomplexwithundecaprenylcoupledintermediatesandmembranelipids AT manuelstrach ca2daptomycintargetscellwallbiosynthesisbyformingatripartitecomplexwithundecaprenylcoupledintermediatesandmembranelipids AT hansgeorgsahl ca2daptomycintargetscellwallbiosynthesisbyformingatripartitecomplexwithundecaprenylcoupledintermediatesandmembranelipids AT ulrichkubitscheck ca2daptomycintargetscellwallbiosynthesisbyformingatripartitecomplexwithundecaprenylcoupledintermediatesandmembranelipids AT tanjaschneider ca2daptomycintargetscellwallbiosynthesisbyformingatripartitecomplexwithundecaprenylcoupledintermediatesandmembranelipids
_version_	1718390232142839808

Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids

Ejemplares similares