Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering

The application of scaffolding materials is believed to hold enormous potential for tissue regeneration. Despite the widespread application and rapid advance of several tissue-engineered scaffolds such as natural and synthetic polymer-based scaffolds, they have limited repair capacity due to the dif...

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Autores principales:	Xuewei Zhang, Xi Chen, Hua Hong, Rubei Hu, Jiashang Liu, Changsheng Liu
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Decellularization ECM 3D scaffolds Tissue regeneration Recellularization Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3f8d4260b79741bea3bee33f28d3e4ed
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spelling	oai:doaj.org-article:3f8d4260b79741bea3bee33f28d3e4ed2021-11-26T04:37:11ZDecellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering2452-199X10.1016/j.bioactmat.2021.09.014https://doaj.org/article/3f8d4260b79741bea3bee33f28d3e4ed2022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X2100431Xhttps://doaj.org/toc/2452-199XThe application of scaffolding materials is believed to hold enormous potential for tissue regeneration. Despite the widespread application and rapid advance of several tissue-engineered scaffolds such as natural and synthetic polymer-based scaffolds, they have limited repair capacity due to the difficulties in overcoming the immunogenicity, simulating in-vivo microenvironment, and performing mechanical or biochemical properties similar to native organs/tissues. Fortunately, the emergence of decellularized extracellular matrix (dECM) scaffolds provides an attractive way to overcome these hurdles, which mimic an optimal non-immune environment with native three-dimensional structures and various bioactive components. The consequent cell-seeded construct based on dECM scaffolds, especially stem cell-recellularized construct, is considered an ideal choice for regenerating functional organs/tissues. Herein, we review recent developments in dECM scaffolds and put forward perspectives accordingly, with particular focus on the concept and fabrication of decellularized scaffolds, as well as the application of decellularized scaffolds and their combinations with stem cells (recellularized scaffolds) in tissue engineering, including skin, bone, nerve, heart, along with lung, liver and kidney.Xuewei ZhangXi ChenHua HongRubei HuJiashang LiuChangsheng LiuKeAi Communications Co., Ltd.articleDecellularizationECM3D scaffoldsTissue regenerationRecellularizationMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 15-31 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Decellularization ECM 3D scaffolds Tissue regeneration Recellularization Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Decellularization ECM 3D scaffolds Tissue regeneration Recellularization Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Xuewei Zhang Xi Chen Hua Hong Rubei Hu Jiashang Liu Changsheng Liu Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering
description	The application of scaffolding materials is believed to hold enormous potential for tissue regeneration. Despite the widespread application and rapid advance of several tissue-engineered scaffolds such as natural and synthetic polymer-based scaffolds, they have limited repair capacity due to the difficulties in overcoming the immunogenicity, simulating in-vivo microenvironment, and performing mechanical or biochemical properties similar to native organs/tissues. Fortunately, the emergence of decellularized extracellular matrix (dECM) scaffolds provides an attractive way to overcome these hurdles, which mimic an optimal non-immune environment with native three-dimensional structures and various bioactive components. The consequent cell-seeded construct based on dECM scaffolds, especially stem cell-recellularized construct, is considered an ideal choice for regenerating functional organs/tissues. Herein, we review recent developments in dECM scaffolds and put forward perspectives accordingly, with particular focus on the concept and fabrication of decellularized scaffolds, as well as the application of decellularized scaffolds and their combinations with stem cells (recellularized scaffolds) in tissue engineering, including skin, bone, nerve, heart, along with lung, liver and kidney.
format	article
author	Xuewei Zhang Xi Chen Hua Hong Rubei Hu Jiashang Liu Changsheng Liu
author_facet	Xuewei Zhang Xi Chen Hua Hong Rubei Hu Jiashang Liu Changsheng Liu
author_sort	Xuewei Zhang
title	Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering
title_short	Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering
title_full	Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering
title_fullStr	Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering
title_full_unstemmed	Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering
title_sort	decellularized extracellular matrix scaffolds: recent trends and emerging strategies in tissue engineering
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/3f8d4260b79741bea3bee33f28d3e4ed
work_keys_str_mv	AT xueweizhang decellularizedextracellularmatrixscaffoldsrecenttrendsandemergingstrategiesintissueengineering AT xichen decellularizedextracellularmatrixscaffoldsrecenttrendsandemergingstrategiesintissueengineering AT huahong decellularizedextracellularmatrixscaffoldsrecenttrendsandemergingstrategiesintissueengineering AT rubeihu decellularizedextracellularmatrixscaffoldsrecenttrendsandemergingstrategiesintissueengineering AT jiashangliu decellularizedextracellularmatrixscaffoldsrecenttrendsandemergingstrategiesintissueengineering AT changshengliu decellularizedextracellularmatrixscaffoldsrecenttrendsandemergingstrategiesintissueengineering
_version_	1718409836661571584

Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering

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