Manual Correction of Voxel Misclassifications in Mesiotemporal Structures Does Not Alter Brain–Behavioral Results in an Episodic Memory Task

Voxel-based morphometry (VBM) is an established method for assessing grey matter volumes across the brain. The quality of magnetic resonance imaging (MRI) and the chosen data preprocessing steps can affect the outcome of VBM analyses. We recognized a lack of publicly available and commonly used prot...

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Autores principales:	Francina Hartmann, Julia Reinhardt, Christoph Stippich, Sabine Krumm
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	voxel-based morphometry voxel misclassification magnetic resonance imaging Alzheimer’s disease DARTEL manual correction Medicine R
Acceso en línea:	https://doaj.org/article/3f8dacdc70f54429976052f7143fd712
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spelling	oai:doaj.org-article:3f8dacdc70f54429976052f7143fd7122021-11-11T17:31:48ZManual Correction of Voxel Misclassifications in Mesiotemporal Structures Does Not Alter Brain–Behavioral Results in an Episodic Memory Task10.3390/jcm102148692077-0383https://doaj.org/article/3f8dacdc70f54429976052f7143fd7122021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4869https://doaj.org/toc/2077-0383Voxel-based morphometry (VBM) is an established method for assessing grey matter volumes across the brain. The quality of magnetic resonance imaging (MRI) and the chosen data preprocessing steps can affect the outcome of VBM analyses. We recognized a lack of publicly available and commonly used protocols, which indicates that standardized and optimized preprocessing protocols are needed. This paper focuses on the time- and resource-consuming manual correction of misclassifications of grey matter voxels in cortical structures important in Alzheimer’s dementia. A total of 126 individuals, including 63 patients with very early Alzheimer’s disease and 63 cognitively normal participants, received thorough neuropsychological testing and 3-Tesla MRI. Automated preprocessing of T1 MPRAGE images was performed, and misclassifications of grey matter voxels were manually identified and corrected. In a second run, the manual correction step was skipped. Multiple regression analyses using DARTEL in SPM8 were then conducted with the manually corrected and uncorrected sample, respectively. Manual correction of voxel misclassifications did not have a major impact on the correlation between episodic memory performance and structural brain imaging results. We conclude that, although performing all preprocessing steps remains the gold standard, skipping manual correction of voxel misclassifications is permitted when investigating populations on the Alzheimer’s disease spectrum.Francina HartmannJulia ReinhardtChristoph StippichSabine KrummMDPI AGarticlevoxel-based morphometryvoxel misclassificationmagnetic resonance imagingAlzheimer’s diseaseDARTELmanual correctionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4869, p 4869 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	voxel-based morphometry voxel misclassification magnetic resonance imaging Alzheimer’s disease DARTEL manual correction Medicine R
spellingShingle	voxel-based morphometry voxel misclassification magnetic resonance imaging Alzheimer’s disease DARTEL manual correction Medicine R Francina Hartmann Julia Reinhardt Christoph Stippich Sabine Krumm Manual Correction of Voxel Misclassifications in Mesiotemporal Structures Does Not Alter Brain–Behavioral Results in an Episodic Memory Task
description	Voxel-based morphometry (VBM) is an established method for assessing grey matter volumes across the brain. The quality of magnetic resonance imaging (MRI) and the chosen data preprocessing steps can affect the outcome of VBM analyses. We recognized a lack of publicly available and commonly used protocols, which indicates that standardized and optimized preprocessing protocols are needed. This paper focuses on the time- and resource-consuming manual correction of misclassifications of grey matter voxels in cortical structures important in Alzheimer’s dementia. A total of 126 individuals, including 63 patients with very early Alzheimer’s disease and 63 cognitively normal participants, received thorough neuropsychological testing and 3-Tesla MRI. Automated preprocessing of T1 MPRAGE images was performed, and misclassifications of grey matter voxels were manually identified and corrected. In a second run, the manual correction step was skipped. Multiple regression analyses using DARTEL in SPM8 were then conducted with the manually corrected and uncorrected sample, respectively. Manual correction of voxel misclassifications did not have a major impact on the correlation between episodic memory performance and structural brain imaging results. We conclude that, although performing all preprocessing steps remains the gold standard, skipping manual correction of voxel misclassifications is permitted when investigating populations on the Alzheimer’s disease spectrum.
format	article
author	Francina Hartmann Julia Reinhardt Christoph Stippich Sabine Krumm
author_facet	Francina Hartmann Julia Reinhardt Christoph Stippich Sabine Krumm
author_sort	Francina Hartmann
title	Manual Correction of Voxel Misclassifications in Mesiotemporal Structures Does Not Alter Brain–Behavioral Results in an Episodic Memory Task
title_short	Manual Correction of Voxel Misclassifications in Mesiotemporal Structures Does Not Alter Brain–Behavioral Results in an Episodic Memory Task
title_full	Manual Correction of Voxel Misclassifications in Mesiotemporal Structures Does Not Alter Brain–Behavioral Results in an Episodic Memory Task
title_fullStr	Manual Correction of Voxel Misclassifications in Mesiotemporal Structures Does Not Alter Brain–Behavioral Results in an Episodic Memory Task
title_full_unstemmed	Manual Correction of Voxel Misclassifications in Mesiotemporal Structures Does Not Alter Brain–Behavioral Results in an Episodic Memory Task
title_sort	manual correction of voxel misclassifications in mesiotemporal structures does not alter brain–behavioral results in an episodic memory task
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3f8dacdc70f54429976052f7143fd712
work_keys_str_mv	AT francinahartmann manualcorrectionofvoxelmisclassificationsinmesiotemporalstructuresdoesnotalterbrainbehavioralresultsinanepisodicmemorytask AT juliareinhardt manualcorrectionofvoxelmisclassificationsinmesiotemporalstructuresdoesnotalterbrainbehavioralresultsinanepisodicmemorytask AT christophstippich manualcorrectionofvoxelmisclassificationsinmesiotemporalstructuresdoesnotalterbrainbehavioralresultsinanepisodicmemorytask AT sabinekrumm manualcorrectionofvoxelmisclassificationsinmesiotemporalstructuresdoesnotalterbrainbehavioralresultsinanepisodicmemorytask
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Manual Correction of Voxel Misclassifications in Mesiotemporal Structures Does Not Alter Brain–Behavioral Results in an Episodic Memory Task

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