Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy

Xiangyang Cheng,1,* Dejian Li,2,* Aiqi Lin,3 Jun Xu,1 Liang Wu,1 Huijie Gu,1 Zhongyue Huang,1 Jiangyi Liu,1 Yiming Zhang,1 Xiaofan Yin1 1Department of Orthopedics, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai 201199, China; 2Department of Orthopedics, Shanghai Pudong Hospital, Fud...

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Autores principales:	Cheng XY, Li DJ, Lin AQ, Xu J, Wu L, Gu HJ, Huang ZY, Liu JY, Zhang YM, Yin XF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	periodic mesoporous organosilica CuS triple-responsive release chemo-photothermal therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3f90005202b648a789fb9c861398cc07
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spelling	oai:doaj.org-article:3f90005202b648a789fb9c861398cc072021-12-02T01:38:31ZFabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy1178-2013https://doaj.org/article/3f90005202b648a789fb9c861398cc072018-06-01T00:00:00Zhttps://www.dovepress.com/fabrication-of-multifunctional-triple-responsive-platform-based-on-cus-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiangyang Cheng,1,* Dejian Li,2,* Aiqi Lin,3 Jun Xu,1 Liang Wu,1 Huijie Gu,1 Zhongyue Huang,1 Jiangyi Liu,1 Yiming Zhang,1 Xiaofan Yin1 1Department of Orthopedics, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai 201199, China; 2Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201301, China; 3Department of Retired, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai 201199, China *These authors contributed equally to this work Introduction: For an ideal drug delivery system, the outstanding drug-loading capacity and specific control of the release of therapeutics at the desired lesions are crucial. In this work, we developed a triple-responsive nanoplatform based on copper sulfide (CuS)-capped yolk-shell-structured periodic mesoporous organosilica nanoparticles (YSPMOs) for synergetic chemo-photothermal therapy. Methods: Herein, the YSPMOs were employed as a drug carrier, which exhibited a high doxorubicin (DOX) loading capacity of 386 mg/g. In this controlled-release drug delivery system, CuS serves as a gatekeeper to modify YSPMOs with reduction-cleavable disulfide bond (YSPMOs@CuS). CuS could not only avoid premature leakage in the delivery process, but also endowed the excellent photothermal therapy (PTT) ability. Results: Upon entering into cancer cells, the CuS gatekeeper was opened with the breaking of disulfide bonds and the DOX release from YSPMOs(DOX)@CuS in response to the intracellular acidic environment and external laser irradiation. Such a precise control over drug release, combined with the photothermal effect of CuS nanoparticles, is possessed by synergistic chemo-photothermal therapy for cancer treatment. Both in vitro and in vivo experimental data indicated that the synergistic effect of YSPMOs(DOX)@CuS showed efficient antitumor effect. In addition, low systemic toxicity was observed in the pathologic examinations of liver, spleen, lungs, and kidneys. Conclusion: This versatile nanoplatform combination of PTT, chemotherapeutics, and gating components shows general potential for designing multifunctional drug delivery systems. Keywords: periodic mesoporous organosilica, CuS, triple-responsive release, chemo-photothermal therapyCheng XYLi DJLin AQXu JWu LGu HJHuang ZYLiu JYZhang YMYin XFDove Medical Pressarticleperiodic mesoporous organosilicaCuStriple-responsive releasechemo-photothermal therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 3661-3677 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	periodic mesoporous organosilica CuS triple-responsive release chemo-photothermal therapy Medicine (General) R5-920
spellingShingle	periodic mesoporous organosilica CuS triple-responsive release chemo-photothermal therapy Medicine (General) R5-920 Cheng XY Li DJ Lin AQ Xu J Wu L Gu HJ Huang ZY Liu JY Zhang YM Yin XF Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy
description	Xiangyang Cheng,1,* Dejian Li,2,* Aiqi Lin,3 Jun Xu,1 Liang Wu,1 Huijie Gu,1 Zhongyue Huang,1 Jiangyi Liu,1 Yiming Zhang,1 Xiaofan Yin1 1Department of Orthopedics, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai 201199, China; 2Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201301, China; 3Department of Retired, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai 201199, China *These authors contributed equally to this work Introduction: For an ideal drug delivery system, the outstanding drug-loading capacity and specific control of the release of therapeutics at the desired lesions are crucial. In this work, we developed a triple-responsive nanoplatform based on copper sulfide (CuS)-capped yolk-shell-structured periodic mesoporous organosilica nanoparticles (YSPMOs) for synergetic chemo-photothermal therapy. Methods: Herein, the YSPMOs were employed as a drug carrier, which exhibited a high doxorubicin (DOX) loading capacity of 386 mg/g. In this controlled-release drug delivery system, CuS serves as a gatekeeper to modify YSPMOs with reduction-cleavable disulfide bond (YSPMOs@CuS). CuS could not only avoid premature leakage in the delivery process, but also endowed the excellent photothermal therapy (PTT) ability. Results: Upon entering into cancer cells, the CuS gatekeeper was opened with the breaking of disulfide bonds and the DOX release from YSPMOs(DOX)@CuS in response to the intracellular acidic environment and external laser irradiation. Such a precise control over drug release, combined with the photothermal effect of CuS nanoparticles, is possessed by synergistic chemo-photothermal therapy for cancer treatment. Both in vitro and in vivo experimental data indicated that the synergistic effect of YSPMOs(DOX)@CuS showed efficient antitumor effect. In addition, low systemic toxicity was observed in the pathologic examinations of liver, spleen, lungs, and kidneys. Conclusion: This versatile nanoplatform combination of PTT, chemotherapeutics, and gating components shows general potential for designing multifunctional drug delivery systems. Keywords: periodic mesoporous organosilica, CuS, triple-responsive release, chemo-photothermal therapy
format	article
author	Cheng XY Li DJ Lin AQ Xu J Wu L Gu HJ Huang ZY Liu JY Zhang YM Yin XF
author_facet	Cheng XY Li DJ Lin AQ Xu J Wu L Gu HJ Huang ZY Liu JY Zhang YM Yin XF
author_sort	Cheng XY
title	Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy
title_short	Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy
title_full	Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy
title_fullStr	Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy
title_full_unstemmed	Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy
title_sort	fabrication of multifunctional triple-responsive platform based on cus-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3f90005202b648a789fb9c861398cc07
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Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy

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