Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity

Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity

Macrophages undergo a Warburg-like switch from oxidative phosphorylation to glycolysis in response to inflammatory stimulus. Here the authors show that fungal melanin can trigger this switch in human macrophages by sequestering calcium in the phagosome and enabling protection against Aspergillus fum...

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Autores principales: Samuel M. Gonçalves, Cláudio Duarte-Oliveira, Cláudia F. Campos, Vishukumar Aimanianda, Rob ter Horst, Luis Leite, Toine Mercier, Paulo Pereira, Miguel Fernández-García, Daniela Antunes, Cláudia S. Rodrigues, Catarina Barbosa-Matos, Joana Gaifem, Inês Mesquita, António Marques, Nuno S. Osório, Egídio Torrado, Fernando Rodrigues, Sandra Costa, Leo AB. Joosten, Katrien Lagrou, Johan Maertens, João F. Lacerda, António Campos, Gordon D. Brown, Axel A. Brakhage, Coral Barbas, Ricardo Silvestre, Frank L. van de Veerdonk, Georgios Chamilos, Mihai G. Netea, Jean-Paul Latgé, Cristina Cunha, Agostinho Carvalho
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/3f93976354b64ccb90d4f627223c4b88
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spelling oai:doaj.org-article:3f93976354b64ccb90d4f627223c4b882021-12-02T14:41:15ZPhagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity10.1038/s41467-020-16120-z2041-1723https://doaj.org/article/3f93976354b64ccb90d4f627223c4b882020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16120-zhttps://doaj.org/toc/2041-1723Macrophages undergo a Warburg-like switch from oxidative phosphorylation to glycolysis in response to inflammatory stimulus. Here the authors show that fungal melanin can trigger this switch in human macrophages by sequestering calcium in the phagosome and enabling protection against Aspergillus fumigatus infection.Samuel M. GonçalvesCláudio Duarte-OliveiraCláudia F. CamposVishukumar AimaniandaRob ter HorstLuis LeiteToine MercierPaulo PereiraMiguel Fernández-GarcíaDaniela AntunesCláudia S. RodriguesCatarina Barbosa-MatosJoana GaifemInês MesquitaAntónio MarquesNuno S. OsórioEgídio TorradoFernando RodriguesSandra CostaLeo AB. JoostenKatrien LagrouJohan MaertensJoão F. LacerdaAntónio CamposGordon D. BrownAxel A. BrakhageCoral BarbasRicardo SilvestreFrank L. van de VeerdonkGeorgios ChamilosMihai G. NeteaJean-Paul LatgéCristina CunhaAgostinho CarvalhoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Samuel M. Gonçalves
Cláudio Duarte-Oliveira
Cláudia F. Campos
Vishukumar Aimanianda
Rob ter Horst
Luis Leite
Toine Mercier
Paulo Pereira
Miguel Fernández-García
Daniela Antunes
Cláudia S. Rodrigues
Catarina Barbosa-Matos
Joana Gaifem
Inês Mesquita
António Marques
Nuno S. Osório
Egídio Torrado
Fernando Rodrigues
Sandra Costa
Leo AB. Joosten
Katrien Lagrou
Johan Maertens
João F. Lacerda
António Campos
Gordon D. Brown
Axel A. Brakhage
Coral Barbas
Ricardo Silvestre
Frank L. van de Veerdonk
Georgios Chamilos
Mihai G. Netea
Jean-Paul Latgé
Cristina Cunha
Agostinho Carvalho
Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity
description Macrophages undergo a Warburg-like switch from oxidative phosphorylation to glycolysis in response to inflammatory stimulus. Here the authors show that fungal melanin can trigger this switch in human macrophages by sequestering calcium in the phagosome and enabling protection against Aspergillus fumigatus infection.
format article
author Samuel M. Gonçalves
Cláudio Duarte-Oliveira
Cláudia F. Campos
Vishukumar Aimanianda
Rob ter Horst
Luis Leite
Toine Mercier
Paulo Pereira
Miguel Fernández-García
Daniela Antunes
Cláudia S. Rodrigues
Catarina Barbosa-Matos
Joana Gaifem
Inês Mesquita
António Marques
Nuno S. Osório
Egídio Torrado
Fernando Rodrigues
Sandra Costa
Leo AB. Joosten
Katrien Lagrou
Johan Maertens
João F. Lacerda
António Campos
Gordon D. Brown
Axel A. Brakhage
Coral Barbas
Ricardo Silvestre
Frank L. van de Veerdonk
Georgios Chamilos
Mihai G. Netea
Jean-Paul Latgé
Cristina Cunha
Agostinho Carvalho
author_facet Samuel M. Gonçalves
Cláudio Duarte-Oliveira
Cláudia F. Campos
Vishukumar Aimanianda
Rob ter Horst
Luis Leite
Toine Mercier
Paulo Pereira
Miguel Fernández-García
Daniela Antunes
Cláudia S. Rodrigues
Catarina Barbosa-Matos
Joana Gaifem
Inês Mesquita
António Marques
Nuno S. Osório
Egídio Torrado
Fernando Rodrigues
Sandra Costa
Leo AB. Joosten
Katrien Lagrou
Johan Maertens
João F. Lacerda
António Campos
Gordon D. Brown
Axel A. Brakhage
Coral Barbas
Ricardo Silvestre
Frank L. van de Veerdonk
Georgios Chamilos
Mihai G. Netea
Jean-Paul Latgé
Cristina Cunha
Agostinho Carvalho
author_sort Samuel M. Gonçalves
title Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity
title_short Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity
title_full Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity
title_fullStr Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity
title_full_unstemmed Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity
title_sort phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/3f93976354b64ccb90d4f627223c4b88
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