Intermittent Hypoxia Exposure Helps to Restore the Reduced Hemoglobin Concentration During Intense Exercise Training in Trained Swimmers

In prolonged intense exercise training, the training load of athletes may be reduced once their hemoglobin concentrations ([Hb]s) are decreased dramatically. We previously reported that intermittent hypoxia exposure (IHE) could be used to alleviate the decrease of [Hb] and help to maintain the train...

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Autores principales:	Xiquan Weng, Jieru Lin, Yu Yuan, Baoxuan Lin, Weiwei Huang, Hiu Tung Tin, Jia Li, Xu Yan, Wentao Lin, Hao Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hypoxia IHE erythropoietin EPO testosterone hemoglobin Physiology QP1-981
Acceso en línea:	https://doaj.org/article/3f946dd8c2914e56b4571b56cf9365e1
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spelling	oai:doaj.org-article:3f946dd8c2914e56b4571b56cf9365e12021-12-01T14:06:11ZIntermittent Hypoxia Exposure Helps to Restore the Reduced Hemoglobin Concentration During Intense Exercise Training in Trained Swimmers1664-042X10.3389/fphys.2021.736108https://doaj.org/article/3f946dd8c2914e56b4571b56cf9365e12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.736108/fullhttps://doaj.org/toc/1664-042XIn prolonged intense exercise training, the training load of athletes may be reduced once their hemoglobin concentrations ([Hb]s) are decreased dramatically. We previously reported that intermittent hypoxia exposure (IHE) could be used to alleviate the decrease of [Hb] and help to maintain the training load in rats. To further explore the feasibility of applying IHE intervention to athletes during prolonged intense exercise training, 6 trained swimmers were recruited to conduct a 4-week IHE intervention at the intervals after their [Hb] dropped for 10% or more during their training season. IHE intervention lasted 1 h and took place once a day and five times a week. Hematological and hormonal parameters, including [Hb], red blood cells (RBC), hematocrit (Hct), reticulocytes, serum erythropoietin (EPO), testosterone (T) and cortisol (C) were examined. After the IHE intervention was launched, [Hb], RBC and Hct of the subjects were increased progressively with their maximum levels (P < 0.01) showing at the third or fourth week, respectively. An increase in reticulocyte count (P < 0.01) suggests that IHE intervention promotes erythropoiesis to increase [Hb]. Besides, serum level of EPO, the hormone known to stimulate erythropoiesis, was overall higher than that before the IHE intervention, although it was statistically insignificant. Furthermore, the serum level of T, another hormone known to stimulate erythropoiesis, was increased progressively with the maximum level showing at the fourth week. Collectively, this study further confirms that IHE intervention may be used as a new strategy to prevent intense exercise training-induced reductions in [Hb].Xiquan WengJieru LinYu YuanBaoxuan LinWeiwei HuangHiu Tung TinJia LiXu YanXu YanWentao LinHao ChenFrontiers Media S.A.articlehypoxiaIHEerythropoietinEPOtestosteronehemoglobinPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypoxia IHE erythropoietin EPO testosterone hemoglobin Physiology QP1-981
spellingShingle	hypoxia IHE erythropoietin EPO testosterone hemoglobin Physiology QP1-981 Xiquan Weng Jieru Lin Yu Yuan Baoxuan Lin Weiwei Huang Hiu Tung Tin Jia Li Xu Yan Xu Yan Wentao Lin Hao Chen Intermittent Hypoxia Exposure Helps to Restore the Reduced Hemoglobin Concentration During Intense Exercise Training in Trained Swimmers
description	In prolonged intense exercise training, the training load of athletes may be reduced once their hemoglobin concentrations ([Hb]s) are decreased dramatically. We previously reported that intermittent hypoxia exposure (IHE) could be used to alleviate the decrease of [Hb] and help to maintain the training load in rats. To further explore the feasibility of applying IHE intervention to athletes during prolonged intense exercise training, 6 trained swimmers were recruited to conduct a 4-week IHE intervention at the intervals after their [Hb] dropped for 10% or more during their training season. IHE intervention lasted 1 h and took place once a day and five times a week. Hematological and hormonal parameters, including [Hb], red blood cells (RBC), hematocrit (Hct), reticulocytes, serum erythropoietin (EPO), testosterone (T) and cortisol (C) were examined. After the IHE intervention was launched, [Hb], RBC and Hct of the subjects were increased progressively with their maximum levels (P < 0.01) showing at the third or fourth week, respectively. An increase in reticulocyte count (P < 0.01) suggests that IHE intervention promotes erythropoiesis to increase [Hb]. Besides, serum level of EPO, the hormone known to stimulate erythropoiesis, was overall higher than that before the IHE intervention, although it was statistically insignificant. Furthermore, the serum level of T, another hormone known to stimulate erythropoiesis, was increased progressively with the maximum level showing at the fourth week. Collectively, this study further confirms that IHE intervention may be used as a new strategy to prevent intense exercise training-induced reductions in [Hb].
format	article
author	Xiquan Weng Jieru Lin Yu Yuan Baoxuan Lin Weiwei Huang Hiu Tung Tin Jia Li Xu Yan Xu Yan Wentao Lin Hao Chen
author_facet	Xiquan Weng Jieru Lin Yu Yuan Baoxuan Lin Weiwei Huang Hiu Tung Tin Jia Li Xu Yan Xu Yan Wentao Lin Hao Chen
author_sort	Xiquan Weng
title	Intermittent Hypoxia Exposure Helps to Restore the Reduced Hemoglobin Concentration During Intense Exercise Training in Trained Swimmers
title_short	Intermittent Hypoxia Exposure Helps to Restore the Reduced Hemoglobin Concentration During Intense Exercise Training in Trained Swimmers
title_full	Intermittent Hypoxia Exposure Helps to Restore the Reduced Hemoglobin Concentration During Intense Exercise Training in Trained Swimmers
title_fullStr	Intermittent Hypoxia Exposure Helps to Restore the Reduced Hemoglobin Concentration During Intense Exercise Training in Trained Swimmers
title_full_unstemmed	Intermittent Hypoxia Exposure Helps to Restore the Reduced Hemoglobin Concentration During Intense Exercise Training in Trained Swimmers
title_sort	intermittent hypoxia exposure helps to restore the reduced hemoglobin concentration during intense exercise training in trained swimmers
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3f946dd8c2914e56b4571b56cf9365e1
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Intermittent Hypoxia Exposure Helps to Restore the Reduced Hemoglobin Concentration During Intense Exercise Training in Trained Swimmers

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