Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions
Implantable biomaterials evoke foreign body responses in the central nervous system. The authors compare hydrogel-based biomaterials to identify cellular interactions and molecular mechanisms that drive different types of foreign body responses that have different effects on biomaterial function.
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Nature Portfolio
2020
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oai:doaj.org-article:3f9ac0fa07be4aa38f0b487bb917087c2021-12-02T15:34:36ZForeign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions10.1038/s41467-020-19906-32041-1723https://doaj.org/article/3f9ac0fa07be4aa38f0b487bb917087c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19906-3https://doaj.org/toc/2041-1723Implantable biomaterials evoke foreign body responses in the central nervous system. The authors compare hydrogel-based biomaterials to identify cellular interactions and molecular mechanisms that drive different types of foreign body responses that have different effects on biomaterial function.Timothy M. OʼSheaAlexander L. WollenbergJae H. KimYan AoTimothy J. DemingMichael V. SofroniewNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020) |
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Science Q |
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Science Q Timothy M. OʼShea Alexander L. Wollenberg Jae H. Kim Yan Ao Timothy J. Deming Michael V. Sofroniew Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions |
description |
Implantable biomaterials evoke foreign body responses in the central nervous system. The authors compare hydrogel-based biomaterials to identify cellular interactions and molecular mechanisms that drive different types of foreign body responses that have different effects on biomaterial function. |
format |
article |
author |
Timothy M. OʼShea Alexander L. Wollenberg Jae H. Kim Yan Ao Timothy J. Deming Michael V. Sofroniew |
author_facet |
Timothy M. OʼShea Alexander L. Wollenberg Jae H. Kim Yan Ao Timothy J. Deming Michael V. Sofroniew |
author_sort |
Timothy M. OʼShea |
title |
Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions |
title_short |
Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions |
title_full |
Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions |
title_fullStr |
Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions |
title_full_unstemmed |
Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions |
title_sort |
foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/3f9ac0fa07be4aa38f0b487bb917087c |
work_keys_str_mv |
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