A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease.
Mirror movements correspond to involuntary movements observed in the limb contralateral to the one performing voluntary movement. They can be observed in Parkinson's disease (PD) but their pathophysiology remains unclear. The present study aims at identifying their neural correlates in PD using...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/3f9d1d2145164185a47560b08087c831 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:3f9d1d2145164185a47560b08087c831 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:3f9d1d2145164185a47560b08087c8312021-11-18T07:40:09ZA functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease.1932-620310.1371/journal.pone.0066910https://doaj.org/article/3f9d1d2145164185a47560b08087c8312013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23825583/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Mirror movements correspond to involuntary movements observed in the limb contralateral to the one performing voluntary movement. They can be observed in Parkinson's disease (PD) but their pathophysiology remains unclear. The present study aims at identifying their neural correlates in PD using functional magnetic resonance imaging. Ten control subjects and 14-off drug patients with asymmetrical right-sided PD were included (8 with left-sided mirror movements during right-hand movements, and 6 without mirror movements). Between-group comparisons of BOLD signal were performed during right-hand movements and at rest (p<0.005 uncorrected). The comparison between PD patients with and without mirror movements showed that mirror movements were associated with an overactivation of the insula, precuneus/posterior cingulate cortex bilaterally and of the left inferior frontal cortex and with a deactivation of the right dorsolateral prefrontal cortex, medial prefrontal cortex, and pre-supplementary motor area and occipital cortex. These data suggest that mirror movements in Parkinson's disease are promoted by: 1- a deactivation of the non-mirroring inhibitory network (dorsolateral prefrontal cortex, pre-supplementary motor area); 2- an overactivation of prokinetic areas (notably the insula). The concomitant overactivation of a proactive inhibitory network (including the posterior cingulate cortex and precuneus) could reflect a compensatory inhibition of mirror movements.Alice PoissonBénédicte BallangerElise MetereauJérome RedoutéDanielle IbarollaJean-Christophe ComteHélène Gervais BernardMarie VidailhetEmmanuel BroussolleStéphane ThoboisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e66910 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Alice Poisson Bénédicte Ballanger Elise Metereau Jérome Redouté Danielle Ibarolla Jean-Christophe Comte Hélène Gervais Bernard Marie Vidailhet Emmanuel Broussolle Stéphane Thobois A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease. |
| description |
Mirror movements correspond to involuntary movements observed in the limb contralateral to the one performing voluntary movement. They can be observed in Parkinson's disease (PD) but their pathophysiology remains unclear. The present study aims at identifying their neural correlates in PD using functional magnetic resonance imaging. Ten control subjects and 14-off drug patients with asymmetrical right-sided PD were included (8 with left-sided mirror movements during right-hand movements, and 6 without mirror movements). Between-group comparisons of BOLD signal were performed during right-hand movements and at rest (p<0.005 uncorrected). The comparison between PD patients with and without mirror movements showed that mirror movements were associated with an overactivation of the insula, precuneus/posterior cingulate cortex bilaterally and of the left inferior frontal cortex and with a deactivation of the right dorsolateral prefrontal cortex, medial prefrontal cortex, and pre-supplementary motor area and occipital cortex. These data suggest that mirror movements in Parkinson's disease are promoted by: 1- a deactivation of the non-mirroring inhibitory network (dorsolateral prefrontal cortex, pre-supplementary motor area); 2- an overactivation of prokinetic areas (notably the insula). The concomitant overactivation of a proactive inhibitory network (including the posterior cingulate cortex and precuneus) could reflect a compensatory inhibition of mirror movements. |
| format |
article |
| author |
Alice Poisson Bénédicte Ballanger Elise Metereau Jérome Redouté Danielle Ibarolla Jean-Christophe Comte Hélène Gervais Bernard Marie Vidailhet Emmanuel Broussolle Stéphane Thobois |
| author_facet |
Alice Poisson Bénédicte Ballanger Elise Metereau Jérome Redouté Danielle Ibarolla Jean-Christophe Comte Hélène Gervais Bernard Marie Vidailhet Emmanuel Broussolle Stéphane Thobois |
| author_sort |
Alice Poisson |
| title |
A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease. |
| title_short |
A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease. |
| title_full |
A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease. |
| title_fullStr |
A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease. |
| title_full_unstemmed |
A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease. |
| title_sort |
functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in parkinson's disease. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/3f9d1d2145164185a47560b08087c831 |
| work_keys_str_mv |
AT alicepoisson afunctionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT benedicteballanger afunctionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT elisemetereau afunctionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT jeromeredoute afunctionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT danielleibarolla afunctionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT jeanchristophecomte afunctionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT helenegervaisbernard afunctionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT marievidailhet afunctionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT emmanuelbroussolle afunctionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT stephanethobois afunctionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT alicepoisson functionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT benedicteballanger functionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT elisemetereau functionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT jeromeredoute functionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT danielleibarolla functionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT jeanchristophecomte functionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT helenegervaisbernard functionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT marievidailhet functionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT emmanuelbroussolle functionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease AT stephanethobois functionalmagneticresonanceimagingstudyofpathophysiologicalchangesresponsibleformirrormovementsinparkinsonsdisease |
| _version_ |
1718423091686670336 |