Analysis of red blood cell irradiation practices from South India

INTRODUCTION: Age of red blood cell (RBC) units at the time of irradiation is important and prolonged storage of preirradiated units is detrimental. The objectives were to determine RBC age at irradiation, days from expiry (DFE), and percentage of late transfusions of irradiated RBC. To estimate the...

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Autores principales:	Mohandoss Murugesan, Merline Augustine, Sangeetha Keloth Nayanar
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	irradiated red blood cell packed red blood cell quality control of red blood cell red blood cell expiry Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/3fa64457f4e4478b891d7262a1d5d759
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spelling	oai:doaj.org-article:3fa64457f4e4478b891d7262a1d5d7592021-11-12T10:08:28ZAnalysis of red blood cell irradiation practices from South India0973-62471998-356510.4103/ajts.ajts_60_21https://doaj.org/article/3fa64457f4e4478b891d7262a1d5d7592021-01-01T00:00:00Zhttp://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=2;spage=199;epage=203;aulast=Murugesanhttps://doaj.org/toc/0973-6247https://doaj.org/toc/1998-3565INTRODUCTION: Age of red blood cell (RBC) units at the time of irradiation is important and prolonged storage of preirradiated units is detrimental. The objectives were to determine RBC age at irradiation, days from expiry (DFE), and percentage of late transfusions of irradiated RBC. To estimate the concordance on expiry of irradiated RBC units with present American Association of Blood Banks (AABB)/Directorate General of Health Services (DGHS), New Delhi over British Committee for Standards in Hematology (BCSH) and Council of Europe (CE) guidelines.METHODS: All the RBC units irradiated for a 1 year period were included. Retrieved data included date of collection, irradiation, revised expiry, and issue of blood. Late transfusions are units transfused in the last 2 week of RBC's shelf-life and wastage due to expiry was determined. Chi-square and Kruskal–Wallis test were used for comparisons between the guidelines.RESULTS: Out of 1303 RBC units irradiated, the median age for irradiation was 2 (0–36) days and 99.3% units irradiated within day +14. Median DFE for these units transfused was 26 (0–28) days. 2.8% units expired as per local standards. Late transfusions happened in 121 (9.3%) units transfused. AABB/DGHS practice was not concordant with CE standards for 86 (6.6%) units and with BCSH 94 (7.2%) units. Overall discordance between the present practices was CE and BCSH was seen in 130 (10%) events.CONCLUSION: Median RBC irradiation age and DFE was two and 26 days respectively at our center. Only 90% concordance was observed between AABB/DGHS and CE/BCSH guidelines with 9.3% units transfused as late transfusions. Restricting late transfusions of irradiated RBC can act as surrogate to improve the quality of units transfused through an inexpensive strategy.Mohandoss MurugesanMerline AugustineSangeetha Keloth NayanarWolters Kluwer Medknow Publicationsarticleirradiated red blood cellpacked red blood cellquality control of red blood cellred blood cell expiryDiseases of the blood and blood-forming organsRC633-647.5ENAsian Journal of Transfusion Science, Vol 15, Iss 2, Pp 199-203 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	irradiated red blood cell packed red blood cell quality control of red blood cell red blood cell expiry Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	irradiated red blood cell packed red blood cell quality control of red blood cell red blood cell expiry Diseases of the blood and blood-forming organs RC633-647.5 Mohandoss Murugesan Merline Augustine Sangeetha Keloth Nayanar Analysis of red blood cell irradiation practices from South India
description	INTRODUCTION: Age of red blood cell (RBC) units at the time of irradiation is important and prolonged storage of preirradiated units is detrimental. The objectives were to determine RBC age at irradiation, days from expiry (DFE), and percentage of late transfusions of irradiated RBC. To estimate the concordance on expiry of irradiated RBC units with present American Association of Blood Banks (AABB)/Directorate General of Health Services (DGHS), New Delhi over British Committee for Standards in Hematology (BCSH) and Council of Europe (CE) guidelines.METHODS: All the RBC units irradiated for a 1 year period were included. Retrieved data included date of collection, irradiation, revised expiry, and issue of blood. Late transfusions are units transfused in the last 2 week of RBC's shelf-life and wastage due to expiry was determined. Chi-square and Kruskal–Wallis test were used for comparisons between the guidelines.RESULTS: Out of 1303 RBC units irradiated, the median age for irradiation was 2 (0–36) days and 99.3% units irradiated within day +14. Median DFE for these units transfused was 26 (0–28) days. 2.8% units expired as per local standards. Late transfusions happened in 121 (9.3%) units transfused. AABB/DGHS practice was not concordant with CE standards for 86 (6.6%) units and with BCSH 94 (7.2%) units. Overall discordance between the present practices was CE and BCSH was seen in 130 (10%) events.CONCLUSION: Median RBC irradiation age and DFE was two and 26 days respectively at our center. Only 90% concordance was observed between AABB/DGHS and CE/BCSH guidelines with 9.3% units transfused as late transfusions. Restricting late transfusions of irradiated RBC can act as surrogate to improve the quality of units transfused through an inexpensive strategy.
format	article
author	Mohandoss Murugesan Merline Augustine Sangeetha Keloth Nayanar
author_facet	Mohandoss Murugesan Merline Augustine Sangeetha Keloth Nayanar
author_sort	Mohandoss Murugesan
title	Analysis of red blood cell irradiation practices from South India
title_short	Analysis of red blood cell irradiation practices from South India
title_full	Analysis of red blood cell irradiation practices from South India
title_fullStr	Analysis of red blood cell irradiation practices from South India
title_full_unstemmed	Analysis of red blood cell irradiation practices from South India
title_sort	analysis of red blood cell irradiation practices from south india
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/3fa64457f4e4478b891d7262a1d5d759
work_keys_str_mv	AT mohandossmurugesan analysisofredbloodcellirradiationpracticesfromsouthindia AT merlineaugustine analysisofredbloodcellirradiationpracticesfromsouthindia AT sangeethakelothnayanar analysisofredbloodcellirradiationpracticesfromsouthindia
_version_	1718431043185278976

Analysis of red blood cell irradiation practices from South India

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