Arthralgia resolution rate following chikungunya virus infection

Background: Arthralgia, persistent pain or stiffness of the joints, is the hallmark symptom of chronic chikungunya virus (CHIKV) disease. Associated with significant disability and reduced quality of life, arthralgia can persist for many months following CHIKV infection. Understanding the expected d...

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Autores principales:	Megan O'Driscoll, Henrik Salje, Aileen Y. Chang, Hugh Watson
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Chikungunya Arthralgia Joint pain Virus Infection Chronic disease Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/3fa840e218c2474bafc06b8365a761f3
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spelling	oai:doaj.org-article:3fa840e218c2474bafc06b8365a761f32021-11-30T04:14:04ZArthralgia resolution rate following chikungunya virus infection1201-971210.1016/j.ijid.2021.08.066https://doaj.org/article/3fa840e218c2474bafc06b8365a761f32021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221006998https://doaj.org/toc/1201-9712Background: Arthralgia, persistent pain or stiffness of the joints, is the hallmark symptom of chronic chikungunya virus (CHIKV) disease. Associated with significant disability and reduced quality of life, arthralgia can persist for many months following CHIKV infection. Understanding the expected duration of arthralgia persistence is important for managing clinical expectations at the individual-level as well as for estimating long-term burdens on population health following a CHIKV epidemic. Methods: A review of cohort studies reporting the prevalence of arthralgia post-CHIKV infection over multiple time points was conducted. Generalized linear models were used to estimate the average rate of arthralgia resolution following CHIKV infection. Results: Sixteen cohort studies matching the inclusion criteria were identified and included in the analysis. An average rate of arthralgia resolution of 10.85% (95% confidence interval (CI) 9.05–12.66%) per month was estimated across studies, corresponding to an expected median time to arthralgia resolution of 6.39 months (95% CI 5.48–7.66 months) and an expected arthralgia prevalence of 72.21% (95% CI 68.40–76.23%) at 3 months post-CHIKV infection. Conclusions: Estimates of the average rate of arthralgia resolution and the expected prevalence of arthralgia over time post-CHIKV infection were derived. These can help inform expectations regarding the long-term public health burdens associated with CHIKV epidemics.Megan O'DriscollHenrik SaljeAileen Y. ChangHugh WatsonElsevierarticleChikungunyaArthralgiaJoint painVirusInfectionChronic diseaseInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chikungunya Arthralgia Joint pain Virus Infection Chronic disease Infectious and parasitic diseases RC109-216
spellingShingle	Chikungunya Arthralgia Joint pain Virus Infection Chronic disease Infectious and parasitic diseases RC109-216 Megan O'Driscoll Henrik Salje Aileen Y. Chang Hugh Watson Arthralgia resolution rate following chikungunya virus infection
description	Background: Arthralgia, persistent pain or stiffness of the joints, is the hallmark symptom of chronic chikungunya virus (CHIKV) disease. Associated with significant disability and reduced quality of life, arthralgia can persist for many months following CHIKV infection. Understanding the expected duration of arthralgia persistence is important for managing clinical expectations at the individual-level as well as for estimating long-term burdens on population health following a CHIKV epidemic. Methods: A review of cohort studies reporting the prevalence of arthralgia post-CHIKV infection over multiple time points was conducted. Generalized linear models were used to estimate the average rate of arthralgia resolution following CHIKV infection. Results: Sixteen cohort studies matching the inclusion criteria were identified and included in the analysis. An average rate of arthralgia resolution of 10.85% (95% confidence interval (CI) 9.05–12.66%) per month was estimated across studies, corresponding to an expected median time to arthralgia resolution of 6.39 months (95% CI 5.48–7.66 months) and an expected arthralgia prevalence of 72.21% (95% CI 68.40–76.23%) at 3 months post-CHIKV infection. Conclusions: Estimates of the average rate of arthralgia resolution and the expected prevalence of arthralgia over time post-CHIKV infection were derived. These can help inform expectations regarding the long-term public health burdens associated with CHIKV epidemics.
format	article
author	Megan O'Driscoll Henrik Salje Aileen Y. Chang Hugh Watson
author_facet	Megan O'Driscoll Henrik Salje Aileen Y. Chang Hugh Watson
author_sort	Megan O'Driscoll
title	Arthralgia resolution rate following chikungunya virus infection
title_short	Arthralgia resolution rate following chikungunya virus infection
title_full	Arthralgia resolution rate following chikungunya virus infection
title_fullStr	Arthralgia resolution rate following chikungunya virus infection
title_full_unstemmed	Arthralgia resolution rate following chikungunya virus infection
title_sort	arthralgia resolution rate following chikungunya virus infection
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/3fa840e218c2474bafc06b8365a761f3
work_keys_str_mv	AT meganodriscoll arthralgiaresolutionratefollowingchikungunyavirusinfection AT henriksalje arthralgiaresolutionratefollowingchikungunyavirusinfection AT aileenychang arthralgiaresolutionratefollowingchikungunyavirusinfection AT hughwatson arthralgiaresolutionratefollowingchikungunyavirusinfection
_version_	1718406797280149504

Arthralgia resolution rate following chikungunya virus infection

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