Influence of doxorubicin on model cell membrane properties: insights from in vitro and in silico studies

Abstract Despite doxorubicin being commonly used in chemotherapy there still remain significant holes in our knowledge regarding its delivery efficacy and an observed resistance mechanism that is postulated to involve the cell membrane. One possible mechanism is the efflux by protein P-gp, which is...

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Autores principales: Ana Catarina Alves, Aniket Magarkar, Miguel Horta, Jose L. F. C. Lima, Alex Bunker, Cláudia Nunes, Salette Reis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3fa980605e2b4fc4a7f70719b932c105
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