Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design

Hyperpolarization methods play a crucial role in the in vivo observation of molecular metabolism by MRI techniques. Here, the authors develop NHC-containing iridium complexes which improve the NMR detectability of 1H, 13C and 15N nuclei via transfer of latent magnetism of para-hydrogen into a substr...

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Autores principales:	Peter J. Rayner, Philip Norcott, Kate M. Appleby, Wissam Iali, Richard O. John, Sam J. Hart, Adrian C. Whitwood, Simon B. Duckett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3fab6706f7ef444298fb209e56531a8d
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spelling	oai:doaj.org-article:3fab6706f7ef444298fb209e56531a8d2021-12-02T16:56:42ZFine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design10.1038/s41467-018-06766-12041-1723https://doaj.org/article/3fab6706f7ef444298fb209e56531a8d2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06766-1https://doaj.org/toc/2041-1723Hyperpolarization methods play a crucial role in the in vivo observation of molecular metabolism by MRI techniques. Here, the authors develop NHC-containing iridium complexes which improve the NMR detectability of 1H, 13C and 15N nuclei via transfer of latent magnetism of para-hydrogen into a substrate.Peter J. RaynerPhilip NorcottKate M. ApplebyWissam IaliRichard O. JohnSam J. HartAdrian C. WhitwoodSimon B. DuckettNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter J. Rayner Philip Norcott Kate M. Appleby Wissam Iali Richard O. John Sam J. Hart Adrian C. Whitwood Simon B. Duckett Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design
description	Hyperpolarization methods play a crucial role in the in vivo observation of molecular metabolism by MRI techniques. Here, the authors develop NHC-containing iridium complexes which improve the NMR detectability of 1H, 13C and 15N nuclei via transfer of latent magnetism of para-hydrogen into a substrate.
format	article
author	Peter J. Rayner Philip Norcott Kate M. Appleby Wissam Iali Richard O. John Sam J. Hart Adrian C. Whitwood Simon B. Duckett
author_facet	Peter J. Rayner Philip Norcott Kate M. Appleby Wissam Iali Richard O. John Sam J. Hart Adrian C. Whitwood Simon B. Duckett
author_sort	Peter J. Rayner
title	Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design
title_short	Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design
title_full	Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design
title_fullStr	Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design
title_full_unstemmed	Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design
title_sort	fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational n-heterocyclic carbene design
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3fab6706f7ef444298fb209e56531a8d
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Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design

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