Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia

Abstract. Ramadhan R, Kristanti AN, Amirta R, Kusuma IW, Phuwapraisirisan P, Haqiqi MT, Saparwadi. 2019. Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia. Biodiversitas 20: 1820-1826. Ten selected plants in this study have been used t...

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Autores principales:	RICO RAMADHAN, ALFINDA NOVI KRISTANTI, RUDIANTO AMIRTA, IRAWAN WIJAYA KUSUMA, PREECHA PHUWAPRAISIRISAN, MUHAMMAD TAUFIQ HAQIQI, SAPARWADI SAPARWADI
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2019
Materias:	antidiabetes, antioxidant, free radical scavenging, α-glucosidase, east kalimantan flora Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3fac192042034b38ac729e7c89b75924
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spelling	oai:doaj.org-article:3fac192042034b38ac729e7c89b759242021-11-21T21:42:27ZScreening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia1412-033X2085-472210.13057/biodiv/d200705https://doaj.org/article/3fac192042034b38ac729e7c89b759242019-06-01T00:00:00Zhttps://smujo.id/biodiv/article/view/3898https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Ramadhan R, Kristanti AN, Amirta R, Kusuma IW, Phuwapraisirisan P, Haqiqi MT, Saparwadi. 2019. Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia. Biodiversitas 20: 1820-1826. Ten selected plants in this study have been used traditionally in West Kutai, East Kalimantan as medicinal plants. This study aimed to screen and evaluate the in vitro antidiabetic and antioxidant activity of methanol extracts of selected plants from East Kalimantan. The antidiabetic activity was carried out by ?-glucosidase inhibitory activity with maltose and sucrose as substrates while antioxidant activity was determined by free radicals scavenging activity against DPPH, ABTS and Nitric Oxide (NO). The results showed that Garcinia riedeliana extract had strong inhibitory activity with an IC50 value of 0.04 mg/mL followed by Shorea laevis, Pternandra azurea and Bridelia tomentosa with IC50 values of 0.12; 0.15 and 0.16 mg/mL in maltose respectively, while quercetin as positive control had an IC50 value of 0.08 mg/mL. G.riedeliana extract also showed good ?-glucosidase inhibitory activity with an IC50 value of 0.23 mg/mL in sucrose as substrate. The results on antioxidant activity showed that all extracts have IC50 value against free radicals DPPH, ABTS, and nitric oxide. The most active extract as ?-glucosidase inhibitory activity and antioxidant activity was G. riedeliana extract. These findings provide the scientific evidence that one species of medicinal plants from East Kalimantan might be potential as an antioxidant and ?-glucosidase inhibitor.RICO RAMADHANALFINDA NOVI KRISTANTIRUDIANTO AMIRTAIRAWAN WIJAYA KUSUMAPREECHA PHUWAPRAISIRISANMUHAMMAD TAUFIQ HAQIQISAPARWADI SAPARWADIMBI & UNS Soloarticleantidiabetes, antioxidant, free radical scavenging, α-glucosidase, east kalimantan floraBiology (General)QH301-705.5ENBiodiversitas, Vol 20, Iss 7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	antidiabetes, antioxidant, free radical scavenging, α-glucosidase, east kalimantan flora Biology (General) QH301-705.5
spellingShingle	antidiabetes, antioxidant, free radical scavenging, α-glucosidase, east kalimantan flora Biology (General) QH301-705.5 RICO RAMADHAN ALFINDA NOVI KRISTANTI RUDIANTO AMIRTA IRAWAN WIJAYA KUSUMA PREECHA PHUWAPRAISIRISAN MUHAMMAD TAUFIQ HAQIQI SAPARWADI SAPARWADI Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia
description	Abstract. Ramadhan R, Kristanti AN, Amirta R, Kusuma IW, Phuwapraisirisan P, Haqiqi MT, Saparwadi. 2019. Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia. Biodiversitas 20: 1820-1826. Ten selected plants in this study have been used traditionally in West Kutai, East Kalimantan as medicinal plants. This study aimed to screen and evaluate the in vitro antidiabetic and antioxidant activity of methanol extracts of selected plants from East Kalimantan. The antidiabetic activity was carried out by ?-glucosidase inhibitory activity with maltose and sucrose as substrates while antioxidant activity was determined by free radicals scavenging activity against DPPH, ABTS and Nitric Oxide (NO). The results showed that Garcinia riedeliana extract had strong inhibitory activity with an IC50 value of 0.04 mg/mL followed by Shorea laevis, Pternandra azurea and Bridelia tomentosa with IC50 values of 0.12; 0.15 and 0.16 mg/mL in maltose respectively, while quercetin as positive control had an IC50 value of 0.08 mg/mL. G.riedeliana extract also showed good ?-glucosidase inhibitory activity with an IC50 value of 0.23 mg/mL in sucrose as substrate. The results on antioxidant activity showed that all extracts have IC50 value against free radicals DPPH, ABTS, and nitric oxide. The most active extract as ?-glucosidase inhibitory activity and antioxidant activity was G. riedeliana extract. These findings provide the scientific evidence that one species of medicinal plants from East Kalimantan might be potential as an antioxidant and ?-glucosidase inhibitor.
format	article
author	RICO RAMADHAN ALFINDA NOVI KRISTANTI RUDIANTO AMIRTA IRAWAN WIJAYA KUSUMA PREECHA PHUWAPRAISIRISAN MUHAMMAD TAUFIQ HAQIQI SAPARWADI SAPARWADI
author_facet	RICO RAMADHAN ALFINDA NOVI KRISTANTI RUDIANTO AMIRTA IRAWAN WIJAYA KUSUMA PREECHA PHUWAPRAISIRISAN MUHAMMAD TAUFIQ HAQIQI SAPARWADI SAPARWADI
author_sort	RICO RAMADHAN
title	Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia
title_short	Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia
title_full	Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia
title_fullStr	Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia
title_full_unstemmed	Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia
title_sort	screening for potential antidiabetes and antioxidant activities of selected plants from east kalimantan, indonesia
publisher	MBI & UNS Solo
publishDate	2019
url	https://doaj.org/article/3fac192042034b38ac729e7c89b75924
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_version_	1718418635599380480

Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia

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