Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

The cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Here, authors use a library of synthetic phosphopeptide analogues of the GPCR rhodopsin C-terminus and determine the ability of these pepti...

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Autores principales:	Daniel Mayer, Fred F. Damberger, Mamidi Samarasimhareddy, Miki Feldmueller, Ziva Vuckovic, Tilman Flock, Brian Bauer, Eshita Mutt, Franziska Zosel, Frédéric H. T. Allain, Jörg Standfuss, Gebhard F. X. Schertler, Xavier Deupi, Martha E. Sommer, Mattan Hurevich, Assaf Friedler, Dmitry B. Veprintsev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3fb017c511b74ac5b642a4f342d8976b
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spelling	oai:doaj.org-article:3fb017c511b74ac5b642a4f342d8976b2021-12-02T14:35:31ZDistinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation10.1038/s41467-019-09204-y2041-1723https://doaj.org/article/3fb017c511b74ac5b642a4f342d8976b2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09204-yhttps://doaj.org/toc/2041-1723The cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Here, authors use a library of synthetic phosphopeptide analogues of the GPCR rhodopsin C-terminus and determine the ability of these peptides to bind and activate arrestins using a variety of biochemical and biophysical methods.Daniel MayerFred F. DambergerMamidi SamarasimhareddyMiki FeldmuellerZiva VuckovicTilman FlockBrian BauerEshita MuttFranziska ZoselFrédéric H. T. AllainJörg StandfussGebhard F. X. SchertlerXavier DeupiMartha E. SommerMattan HurevichAssaf FriedlerDmitry B. VeprintsevNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Mayer Fred F. Damberger Mamidi Samarasimhareddy Miki Feldmueller Ziva Vuckovic Tilman Flock Brian Bauer Eshita Mutt Franziska Zosel Frédéric H. T. Allain Jörg Standfuss Gebhard F. X. Schertler Xavier Deupi Martha E. Sommer Mattan Hurevich Assaf Friedler Dmitry B. Veprintsev Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
description	The cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Here, authors use a library of synthetic phosphopeptide analogues of the GPCR rhodopsin C-terminus and determine the ability of these peptides to bind and activate arrestins using a variety of biochemical and biophysical methods.
format	article
author	Daniel Mayer Fred F. Damberger Mamidi Samarasimhareddy Miki Feldmueller Ziva Vuckovic Tilman Flock Brian Bauer Eshita Mutt Franziska Zosel Frédéric H. T. Allain Jörg Standfuss Gebhard F. X. Schertler Xavier Deupi Martha E. Sommer Mattan Hurevich Assaf Friedler Dmitry B. Veprintsev
author_facet	Daniel Mayer Fred F. Damberger Mamidi Samarasimhareddy Miki Feldmueller Ziva Vuckovic Tilman Flock Brian Bauer Eshita Mutt Franziska Zosel Frédéric H. T. Allain Jörg Standfuss Gebhard F. X. Schertler Xavier Deupi Martha E. Sommer Mattan Hurevich Assaf Friedler Dmitry B. Veprintsev
author_sort	Daniel Mayer
title	Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
title_short	Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
title_full	Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
title_fullStr	Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
title_full_unstemmed	Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
title_sort	distinct g protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3fb017c511b74ac5b642a4f342d8976b
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Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

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