Origin of OXA-23 Variant OXA-239 from a Recently Emerged Lineage of <named-content content-type="genus-species">Acinetobacter baumannii</named-content> International Clone V

ABSTRACT Over the last few decades, carbapenemase-producing Acinetobacter baumannii has become a major cause of nosocomial infections all over the world. However, the genome identity of lineages of this species in Latin America has not been studied as much as in developed countries. Here, through a...

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Autores principales:	Lucia Graña-Miraglia, Benjamin A. Evans, Luis E. López-Jácome, Melissa Hernández-Durán, Claudia Adriana Colín-Castro, Patricia Volkow-Fernández, Miguel A. Cevallos, Rafael Franco-Cendejas, Santiago Castillo-Ramírez
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	evolutionary biology infectious diseases population genomics Acinetobacter baumannii OXA β-lactamases OXA-239 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3fb680e56c9d48c7ae3d404b7c6e822c
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spelling	oai:doaj.org-article:3fb680e56c9d48c7ae3d404b7c6e822c2021-11-15T15:27:53ZOrigin of OXA-23 Variant OXA-239 from a Recently Emerged Lineage of <named-content content-type="genus-species">Acinetobacter baumannii</named-content> International Clone V10.1128/mSphere.00801-192379-5042https://doaj.org/article/3fb680e56c9d48c7ae3d404b7c6e822c2020-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00801-19https://doaj.org/toc/2379-5042ABSTRACT Over the last few decades, carbapenemase-producing Acinetobacter baumannii has become a major cause of nosocomial infections all over the world. However, the genome identity of lineages of this species in Latin America has not been studied as much as in developed countries. Here, through a population genomics approach considering the whole genomes of 148 isolates (almost 40 from Mexico and Honduras), we describe the recent emergence of the lineage sequence type 758 (ST758), which belongs to the international clone V and has spread out to Canada, Mexico, Honduras, and Colombia. Notably, this lineage was found to coexist with other A. baumannii lineages in hospitals in Mexico and Honduras. Isolates from this lineage show considerable variation in antibiotic resistance profiles, but most of them are resistant to carbapenems. Moreover, we found a variety of acquired oxacillinase (OXA) families within this lineage and tracked the very recent inception, and subsequent horizontal transmission, of the OXA-239 carbapenemase. This work highlights the urgent need to investigate recently emerged lineages of this species in Latin America and elsewhere, as these might harbor novel antibiotic resistance genes. IMPORTANCE A. baumannii is a major cause of nosocomial infections all over the world. Although many isolates from developed countries have been studied in terms of their genome sequence, isolates from Latin America have been much less studied. In this study, using a population genomics approach considering the whole genomes of 148 isolates, we describe the recent emergence of the lineage ST758 endemic to Latin America and the inception of the OXA-239 carbapenemase. Our study highlights the urgent need to investigate recently emerged lineages of this species in Latin America and elsewhere, as these might harbor novel antibiotic resistance genes.Lucia Graña-MiragliaBenjamin A. EvansLuis E. López-JácomeMelissa Hernández-DuránClaudia Adriana Colín-CastroPatricia Volkow-FernándezMiguel A. CevallosRafael Franco-CendejasSantiago Castillo-RamírezAmerican Society for Microbiologyarticleevolutionary biologyinfectious diseasespopulation genomicsAcinetobacter baumanniiOXA β-lactamasesOXA-239MicrobiologyQR1-502ENmSphere, Vol 5, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	evolutionary biology infectious diseases population genomics Acinetobacter baumannii OXA β-lactamases OXA-239 Microbiology QR1-502
spellingShingle	evolutionary biology infectious diseases population genomics Acinetobacter baumannii OXA β-lactamases OXA-239 Microbiology QR1-502 Lucia Graña-Miraglia Benjamin A. Evans Luis E. López-Jácome Melissa Hernández-Durán Claudia Adriana Colín-Castro Patricia Volkow-Fernández Miguel A. Cevallos Rafael Franco-Cendejas Santiago Castillo-Ramírez Origin of OXA-23 Variant OXA-239 from a Recently Emerged Lineage of <named-content content-type="genus-species">Acinetobacter baumannii</named-content> International Clone V
description	ABSTRACT Over the last few decades, carbapenemase-producing Acinetobacter baumannii has become a major cause of nosocomial infections all over the world. However, the genome identity of lineages of this species in Latin America has not been studied as much as in developed countries. Here, through a population genomics approach considering the whole genomes of 148 isolates (almost 40 from Mexico and Honduras), we describe the recent emergence of the lineage sequence type 758 (ST758), which belongs to the international clone V and has spread out to Canada, Mexico, Honduras, and Colombia. Notably, this lineage was found to coexist with other A. baumannii lineages in hospitals in Mexico and Honduras. Isolates from this lineage show considerable variation in antibiotic resistance profiles, but most of them are resistant to carbapenems. Moreover, we found a variety of acquired oxacillinase (OXA) families within this lineage and tracked the very recent inception, and subsequent horizontal transmission, of the OXA-239 carbapenemase. This work highlights the urgent need to investigate recently emerged lineages of this species in Latin America and elsewhere, as these might harbor novel antibiotic resistance genes. IMPORTANCE A. baumannii is a major cause of nosocomial infections all over the world. Although many isolates from developed countries have been studied in terms of their genome sequence, isolates from Latin America have been much less studied. In this study, using a population genomics approach considering the whole genomes of 148 isolates, we describe the recent emergence of the lineage ST758 endemic to Latin America and the inception of the OXA-239 carbapenemase. Our study highlights the urgent need to investigate recently emerged lineages of this species in Latin America and elsewhere, as these might harbor novel antibiotic resistance genes.
format	article
author	Lucia Graña-Miraglia Benjamin A. Evans Luis E. López-Jácome Melissa Hernández-Durán Claudia Adriana Colín-Castro Patricia Volkow-Fernández Miguel A. Cevallos Rafael Franco-Cendejas Santiago Castillo-Ramírez
author_facet	Lucia Graña-Miraglia Benjamin A. Evans Luis E. López-Jácome Melissa Hernández-Durán Claudia Adriana Colín-Castro Patricia Volkow-Fernández Miguel A. Cevallos Rafael Franco-Cendejas Santiago Castillo-Ramírez
author_sort	Lucia Graña-Miraglia
title	Origin of OXA-23 Variant OXA-239 from a Recently Emerged Lineage of <named-content content-type="genus-species">Acinetobacter baumannii</named-content> International Clone V
title_short	Origin of OXA-23 Variant OXA-239 from a Recently Emerged Lineage of <named-content content-type="genus-species">Acinetobacter baumannii</named-content> International Clone V
title_full	Origin of OXA-23 Variant OXA-239 from a Recently Emerged Lineage of <named-content content-type="genus-species">Acinetobacter baumannii</named-content> International Clone V
title_fullStr	Origin of OXA-23 Variant OXA-239 from a Recently Emerged Lineage of <named-content content-type="genus-species">Acinetobacter baumannii</named-content> International Clone V
title_full_unstemmed	Origin of OXA-23 Variant OXA-239 from a Recently Emerged Lineage of <named-content content-type="genus-species">Acinetobacter baumannii</named-content> International Clone V
title_sort	origin of oxa-23 variant oxa-239 from a recently emerged lineage of <named-content content-type="genus-species">acinetobacter baumannii</named-content> international clone v
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/3fb680e56c9d48c7ae3d404b7c6e822c
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Origin of OXA-23 Variant OXA-239 from a Recently Emerged Lineage of <named-content content-type="genus-species">Acinetobacter baumannii</named-content> International Clone V

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