Neonatal thyrotropin levels and auditory neural maturation in full-term newborns.

<h4>Objective</h4>This study aimed to look for a possible relationship between thyrotropin (TSH) values from neonatal bloodspot screening testing and newborn lower auditory pathway myelinization evaluated using the brainstem evoked response audiometry (ABR) test.<h4>Methods</h4&...

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Autores principales:	Leticia Valerio Pallone, Laura Carvalho Navarra, Gleice Aline Gonçalves, Felipe Alves de Jesus, Debora Gusmão Melo, Rodrigo Alves Ferreira, Carla Maria Ramos Germano
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3fb803d5c357458b82779b836f68e3e4
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spelling	oai:doaj.org-article:3fb803d5c357458b82779b836f68e3e42021-12-02T20:10:34ZNeonatal thyrotropin levels and auditory neural maturation in full-term newborns.1932-620310.1371/journal.pone.0253229https://doaj.org/article/3fb803d5c357458b82779b836f68e3e42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253229https://doaj.org/toc/1932-6203<h4>Objective</h4>This study aimed to look for a possible relationship between thyrotropin (TSH) values from neonatal bloodspot screening testing and newborn lower auditory pathway myelinization evaluated using the brainstem evoked response audiometry (ABR) test.<h4>Methods</h4>Sixty-two healthy full-term newborns without perinatal problems were enrolled in the study. TSH results were collected from neonatal bloodspot screening data and were below the test cut-off level (15μUI/mL). The TSH test was performed between three and seven days, and the ABR test was performed in the first 28 days of life. The newborns were divided into two groups: Group 1 (n = 35), TSH between 0 and 5μUI/mL, and group 2 (n = 27), TSH between 5 and 15μUI/mL. Data are presented as mean ± SD, median, or percentage, depending on the variable.<h4>Results</h4>Wave latency and interpeak interval values for Groups 1 and 2 were as follows: Wave I: 1.8 ± 0.1 and 1.7 ± 0.1; Wave III: 4.4 ± 0.1 and 4.4 ± 0.1; Wave V: 6.9 ± 0.1 and 6.9 ± 0.1; interval I-III: 2.6 ± 0.1 and 2.6 ± 0.1; interval I-V: 5.1 ± 0.1 and 5.1 ± 0.1; interval III-V: 2.4 ± 0.1 and 2.4 ± 0.1. There were no significant differences in ABR parameters between groups 1 and 2 (p > 0.05). Multiple regression analysis showed a slight significant negative correlation between TSH and wave I values (standardized β = -0.267; p = 0.036), without observing any relationship with the other ABR waves recorded.<h4>Conclusions</h4>This study investigated the relationship of TSH and auditory myelinization evaluated by ABR. It did not show a significant change in lower auditory pathway myelinization according to TSH levels in newborns with TSH screening levels lower than 15 μUI/mL.Leticia Valerio PalloneLaura Carvalho NavarraGleice Aline GonçalvesFelipe Alves de JesusDebora Gusmão MeloRodrigo Alves FerreiraCarla Maria Ramos GermanoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253229 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leticia Valerio Pallone Laura Carvalho Navarra Gleice Aline Gonçalves Felipe Alves de Jesus Debora Gusmão Melo Rodrigo Alves Ferreira Carla Maria Ramos Germano Neonatal thyrotropin levels and auditory neural maturation in full-term newborns.
description	<h4>Objective</h4>This study aimed to look for a possible relationship between thyrotropin (TSH) values from neonatal bloodspot screening testing and newborn lower auditory pathway myelinization evaluated using the brainstem evoked response audiometry (ABR) test.<h4>Methods</h4>Sixty-two healthy full-term newborns without perinatal problems were enrolled in the study. TSH results were collected from neonatal bloodspot screening data and were below the test cut-off level (15μUI/mL). The TSH test was performed between three and seven days, and the ABR test was performed in the first 28 days of life. The newborns were divided into two groups: Group 1 (n = 35), TSH between 0 and 5μUI/mL, and group 2 (n = 27), TSH between 5 and 15μUI/mL. Data are presented as mean ± SD, median, or percentage, depending on the variable.<h4>Results</h4>Wave latency and interpeak interval values for Groups 1 and 2 were as follows: Wave I: 1.8 ± 0.1 and 1.7 ± 0.1; Wave III: 4.4 ± 0.1 and 4.4 ± 0.1; Wave V: 6.9 ± 0.1 and 6.9 ± 0.1; interval I-III: 2.6 ± 0.1 and 2.6 ± 0.1; interval I-V: 5.1 ± 0.1 and 5.1 ± 0.1; interval III-V: 2.4 ± 0.1 and 2.4 ± 0.1. There were no significant differences in ABR parameters between groups 1 and 2 (p > 0.05). Multiple regression analysis showed a slight significant negative correlation between TSH and wave I values (standardized β = -0.267; p = 0.036), without observing any relationship with the other ABR waves recorded.<h4>Conclusions</h4>This study investigated the relationship of TSH and auditory myelinization evaluated by ABR. It did not show a significant change in lower auditory pathway myelinization according to TSH levels in newborns with TSH screening levels lower than 15 μUI/mL.
format	article
author	Leticia Valerio Pallone Laura Carvalho Navarra Gleice Aline Gonçalves Felipe Alves de Jesus Debora Gusmão Melo Rodrigo Alves Ferreira Carla Maria Ramos Germano
author_facet	Leticia Valerio Pallone Laura Carvalho Navarra Gleice Aline Gonçalves Felipe Alves de Jesus Debora Gusmão Melo Rodrigo Alves Ferreira Carla Maria Ramos Germano
author_sort	Leticia Valerio Pallone
title	Neonatal thyrotropin levels and auditory neural maturation in full-term newborns.
title_short	Neonatal thyrotropin levels and auditory neural maturation in full-term newborns.
title_full	Neonatal thyrotropin levels and auditory neural maturation in full-term newborns.
title_fullStr	Neonatal thyrotropin levels and auditory neural maturation in full-term newborns.
title_full_unstemmed	Neonatal thyrotropin levels and auditory neural maturation in full-term newborns.
title_sort	neonatal thyrotropin levels and auditory neural maturation in full-term newborns.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3fb803d5c357458b82779b836f68e3e4
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Neonatal thyrotropin levels and auditory neural maturation in full-term newborns.

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