Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema

AIM: To quantitatively detect aqueous levels of angiopoietin-like (ANGPTL)3, ANGPTL4, and ANGPTL6 and investigate their correlation with optical coherence tomography angiography (OCTA) findings in patients with diabetic macular edema (DME). METHODS: This cross-sectional study included 23 patients (2...

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Autores principales:	Jie Yan, Wu-Jun Li, Ya-Zhou Qin, Xuan-Yu Qiu, Li Qin, Jing-Ming Li
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	diabetic retinopathy diabetic macular edema optical coherence tomography angiography angiopoietin-like vascular leakage Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/3fb9b1bdec124feba3804534ab1d7b9a
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spelling	oai:doaj.org-article:3fb9b1bdec124feba3804534ab1d7b9a2021-11-26T04:02:12ZAqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema2222-39592227-489810.18240/ijo.2021.12.12https://doaj.org/article/3fb9b1bdec124feba3804534ab1d7b9a2021-12-01T00:00:00Zhttp://ies.ijo.cn/en_publish/2021/12/20211212.pdfhttps://doaj.org/toc/2222-3959https://doaj.org/toc/2227-4898AIM: To quantitatively detect aqueous levels of angiopoietin-like (ANGPTL)3, ANGPTL4, and ANGPTL6 and investigate their correlation with optical coherence tomography angiography (OCTA) findings in patients with diabetic macular edema (DME). METHODS: This cross-sectional study included 23 patients (27 eyes) with type 2 diabetes and 16 control subjects (20 eyes). All patients underwent OCTA imaging and ultra-wide field fundus photography. Diabetic patients were categorized into two groups according to the presence or absence of diabetic retinopathy (DME group, 14 patients, 16 eyes); and non-diabetic retinopathy (NDR) group, 9 patients, 11 eyes, respectively. Aqueous levels of ANGPTL3, ANGPTL4, and ANGPTL6 were assessed using suspension array technology, and foveal-centered 3×3 mm2 OCTA scans were automatically graded to determine the central, inner, and full vessel density (CVD, IVD, FVD); central, inner, and full perfusion density (CPD, IPD, FPD), foveal avascular zone (FAZ) area, FAZ perimeter, and FAZ circularity index (FAZ-CI) on superficial capillary plexuses. Additionally, central subfield thickness (CST), cube volume (CV), and cube average thickness (CAT) were measured in a model of macular cube 512×128. RESULTS: Aqueous ANGPTL3 levels were not significantly different among the three groups (P>0.05). ANGPTL4 levels were significantly higher in the DME group than the control and NDR groups (P<0.0001 and P<0.001), while ANGPTL6 levels were significantly higher in the DME group than the control group (P<0.05). In the whole cohort, the aqueous ANGPTL3 levels correlated negatively with the IVD, FVD, IPD, and FPD, and positively with the CV and CAT. The aqueous ANGPTL4 levels correlated negatively with the CVD, IVD, FVD, CPD, IPD, and FPD, and positively with the FAZ perimeter, CST, CV, and CAT. The aqueous ANGPTL6 levels correlated negatively with the IVD, FVD, IPD, FPD, FAZ-CI and positively with CST, CV, CAT. CONCLUSION: ANGPTL4 and ANGPTL6 may be associated with vascular leakage in DME and may represent good targets for DME therapy. In addition, OCTA metrics may be useful for evaluating macular ischemia in DME.Jie YanWu-Jun LiYa-Zhou QinXuan-Yu QiuLi QinJing-Ming LiPress of International Journal of Ophthalmology (IJO PRESS)articlediabetic retinopathydiabetic macular edemaoptical coherence tomography angiographyangiopoietin-likevascular leakageOphthalmologyRE1-994ENInternational Journal of Ophthalmology, Vol 14, Iss 12, Pp 1888-1894 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic retinopathy diabetic macular edema optical coherence tomography angiography angiopoietin-like vascular leakage Ophthalmology RE1-994
spellingShingle	diabetic retinopathy diabetic macular edema optical coherence tomography angiography angiopoietin-like vascular leakage Ophthalmology RE1-994 Jie Yan Wu-Jun Li Ya-Zhou Qin Xuan-Yu Qiu Li Qin Jing-Ming Li Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema
description	AIM: To quantitatively detect aqueous levels of angiopoietin-like (ANGPTL)3, ANGPTL4, and ANGPTL6 and investigate their correlation with optical coherence tomography angiography (OCTA) findings in patients with diabetic macular edema (DME). METHODS: This cross-sectional study included 23 patients (27 eyes) with type 2 diabetes and 16 control subjects (20 eyes). All patients underwent OCTA imaging and ultra-wide field fundus photography. Diabetic patients were categorized into two groups according to the presence or absence of diabetic retinopathy (DME group, 14 patients, 16 eyes); and non-diabetic retinopathy (NDR) group, 9 patients, 11 eyes, respectively. Aqueous levels of ANGPTL3, ANGPTL4, and ANGPTL6 were assessed using suspension array technology, and foveal-centered 3×3 mm2 OCTA scans were automatically graded to determine the central, inner, and full vessel density (CVD, IVD, FVD); central, inner, and full perfusion density (CPD, IPD, FPD), foveal avascular zone (FAZ) area, FAZ perimeter, and FAZ circularity index (FAZ-CI) on superficial capillary plexuses. Additionally, central subfield thickness (CST), cube volume (CV), and cube average thickness (CAT) were measured in a model of macular cube 512×128. RESULTS: Aqueous ANGPTL3 levels were not significantly different among the three groups (P>0.05). ANGPTL4 levels were significantly higher in the DME group than the control and NDR groups (P<0.0001 and P<0.001), while ANGPTL6 levels were significantly higher in the DME group than the control group (P<0.05). In the whole cohort, the aqueous ANGPTL3 levels correlated negatively with the IVD, FVD, IPD, and FPD, and positively with the CV and CAT. The aqueous ANGPTL4 levels correlated negatively with the CVD, IVD, FVD, CPD, IPD, and FPD, and positively with the FAZ perimeter, CST, CV, and CAT. The aqueous ANGPTL6 levels correlated negatively with the IVD, FVD, IPD, FPD, FAZ-CI and positively with CST, CV, CAT. CONCLUSION: ANGPTL4 and ANGPTL6 may be associated with vascular leakage in DME and may represent good targets for DME therapy. In addition, OCTA metrics may be useful for evaluating macular ischemia in DME.
format	article
author	Jie Yan Wu-Jun Li Ya-Zhou Qin Xuan-Yu Qiu Li Qin Jing-Ming Li
author_facet	Jie Yan Wu-Jun Li Ya-Zhou Qin Xuan-Yu Qiu Li Qin Jing-Ming Li
author_sort	Jie Yan
title	Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema
title_short	Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema
title_full	Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema
title_fullStr	Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema
title_full_unstemmed	Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema
title_sort	aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/3fb9b1bdec124feba3804534ab1d7b9a
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Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema

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