Anaemia in pregnancy is associated with advanced HIV disease.

<h4>Background</h4>Anaemia is a common clinical finding in HIV infected women and has been associated with advanced disease. The use of antiretroviral drugs such as Zidovudine (ZDV) either for prevention of mother to child transmission (MTCT) of HIV or used in combination with other anti...

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Autores principales:	Vikesh Nandlal, Dhayendre Moodley, Anneke Grobler, Jayanthilall Bagratee, Niren R Maharaj, Paul Richardson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3fba162074694a759a4291b629ce1aa4
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spelling	oai:doaj.org-article:3fba162074694a759a4291b629ce1aa42021-11-25T06:00:42ZAnaemia in pregnancy is associated with advanced HIV disease.1932-620310.1371/journal.pone.0106103https://doaj.org/article/3fba162074694a759a4291b629ce1aa42014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0106103https://doaj.org/toc/1932-6203<h4>Background</h4>Anaemia is a common clinical finding in HIV infected women and has been associated with advanced disease. The use of antiretroviral drugs such as Zidovudine (ZDV) either for prevention of mother to child transmission (MTCT) of HIV or used in combination with other antiretrovirals have been implicated in the development or increased severity of anaemia. We report the prevalence, type, severity and incidence of anaemia in a cohort of HIV infected women who initiated antiretroviral prophylaxis or treatment during pregnancy.<h4>Methods and materials</h4>This is a retrospective cohort data analysis of 408 HIV infected pregnant women who participated in a breastfeeding intervention study (HPTN 046 Study, ClinicalTrials.gov NCT 00074412) in South Africa. Women initiated zidovudine prophylaxis for PMTCT or triple antiretroviral treatment in pregnancy according to the standard of care. Laboratory and clinical data in pregnancy, <72 hours and 2 weeks postdelivery were extracted from the main database and analysed.<h4>Results</h4>The mean Hb concentration was 10.6 g/dL at baseline and 262/408 (64.2%) women were diagnosed with anaemia (Hb<11 g/dL) in pregnancy, 48/146 (32.9%) subsequently developed anaemia intrapartum or postpartum and 89/310 (28.7%) of all cases of anaemia remained unresolved by 2 weeks postdelivery. In a univariate analysis, CD4 count and gravidity were significant risk factors for anaemia in pregnancy, RR 1.41; 1.23-1.61 (p<0.001) and 1.10; 1.01-1.18 (p = 0.02) respectively. After adjusting for antiretroviral regimen, age and gravidity in a multivariable analysis, only the CD4 count remains a significant risk factor for anaemia in pregnancy and postdelivery.<h4>Conclusion</h4>In conclusion, anaemia was most common among women in the advanced stage of HIV infection (CD4<200 cells/mm3). There was no evidence of an association between ZDV or triple ARVs and anaemia.Vikesh NandlalDhayendre MoodleyAnneke GroblerJayanthilall BagrateeNiren R MaharajPaul RichardsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e106103 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vikesh Nandlal Dhayendre Moodley Anneke Grobler Jayanthilall Bagratee Niren R Maharaj Paul Richardson Anaemia in pregnancy is associated with advanced HIV disease.
description	<h4>Background</h4>Anaemia is a common clinical finding in HIV infected women and has been associated with advanced disease. The use of antiretroviral drugs such as Zidovudine (ZDV) either for prevention of mother to child transmission (MTCT) of HIV or used in combination with other antiretrovirals have been implicated in the development or increased severity of anaemia. We report the prevalence, type, severity and incidence of anaemia in a cohort of HIV infected women who initiated antiretroviral prophylaxis or treatment during pregnancy.<h4>Methods and materials</h4>This is a retrospective cohort data analysis of 408 HIV infected pregnant women who participated in a breastfeeding intervention study (HPTN 046 Study, ClinicalTrials.gov NCT 00074412) in South Africa. Women initiated zidovudine prophylaxis for PMTCT or triple antiretroviral treatment in pregnancy according to the standard of care. Laboratory and clinical data in pregnancy, <72 hours and 2 weeks postdelivery were extracted from the main database and analysed.<h4>Results</h4>The mean Hb concentration was 10.6 g/dL at baseline and 262/408 (64.2%) women were diagnosed with anaemia (Hb<11 g/dL) in pregnancy, 48/146 (32.9%) subsequently developed anaemia intrapartum or postpartum and 89/310 (28.7%) of all cases of anaemia remained unresolved by 2 weeks postdelivery. In a univariate analysis, CD4 count and gravidity were significant risk factors for anaemia in pregnancy, RR 1.41; 1.23-1.61 (p<0.001) and 1.10; 1.01-1.18 (p = 0.02) respectively. After adjusting for antiretroviral regimen, age and gravidity in a multivariable analysis, only the CD4 count remains a significant risk factor for anaemia in pregnancy and postdelivery.<h4>Conclusion</h4>In conclusion, anaemia was most common among women in the advanced stage of HIV infection (CD4<200 cells/mm3). There was no evidence of an association between ZDV or triple ARVs and anaemia.
format	article
author	Vikesh Nandlal Dhayendre Moodley Anneke Grobler Jayanthilall Bagratee Niren R Maharaj Paul Richardson
author_facet	Vikesh Nandlal Dhayendre Moodley Anneke Grobler Jayanthilall Bagratee Niren R Maharaj Paul Richardson
author_sort	Vikesh Nandlal
title	Anaemia in pregnancy is associated with advanced HIV disease.
title_short	Anaemia in pregnancy is associated with advanced HIV disease.
title_full	Anaemia in pregnancy is associated with advanced HIV disease.
title_fullStr	Anaemia in pregnancy is associated with advanced HIV disease.
title_full_unstemmed	Anaemia in pregnancy is associated with advanced HIV disease.
title_sort	anaemia in pregnancy is associated with advanced hiv disease.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/3fba162074694a759a4291b629ce1aa4
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Anaemia in pregnancy is associated with advanced HIV disease.

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