Autonomic and Somatic Nerve Functions in Type 2 Diabetes Mellitus Patients: Electrophysiological Aspects

Objectives: To investigate the relationship between neurophysiological sensory and motor nerve function parameters, assessed by nerve conduction studies (NCS) with parasympathetic autonomic function and by heart rate variability (HRV) tests in patients with type 2 diabetes mellitus (T2DM). Material...

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Autores principales:	Anca Motataianu, Laura Barcutean, Zoltan Bajko, Adina Stoian, Smaranda Maier, Septimiu Voidazan, Rodica Balasa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetic neuropathy diabetes mellitus heart rate variability nerve conduction studies Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3fbab7685fbb4fb482fe27d702075a96
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spelling	oai:doaj.org-article:3fbab7685fbb4fb482fe27d702075a962021-11-25T17:20:40ZAutonomic and Somatic Nerve Functions in Type 2 Diabetes Mellitus Patients: Electrophysiological Aspects10.3390/diagnostics111120052075-4418https://doaj.org/article/3fbab7685fbb4fb482fe27d702075a962021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2005https://doaj.org/toc/2075-4418Objectives: To investigate the relationship between neurophysiological sensory and motor nerve function parameters, assessed by nerve conduction studies (NCS) with parasympathetic autonomic function and by heart rate variability (HRV) tests in patients with type 2 diabetes mellitus (T2DM). Material and Methods: A total of 161 T2DM patients underwent NCS. Cardiac autonomic response was assessed by HRV tests to deep breathing (HRV DB), to Valsalva manoeuvre, and during postural change from lying to standing. Results: The amplitude of motor response in the median nerve, tibial nerve, and peroneal nerve was associated with reduced HRV DB (<i>p</i> = 0.0001). The amplitude of motor response in the median nerve, tibial nerve, and peroneal nerve was associated with reduced HRV Valsalva (<i>p</i> = 0.0001). The correlation between the amplitude of response in all sensory nerves (sural, median, and ulnar) and HRV DB was statistically significant (<i>p</i> = 0.0001). Conclusion: The results indicate that there is a correlation in T2DM patients between the damage of small myelinated and unmyelinated nerve fibres from cardiac autonomic nerves, assessed by HRV tests and damage of large motor and sensory fibres, assessed by NCS. Based on the above results, a combination of NCS and HRV tests should be considered in the neurophysiological approach to diabetic neuropathy.Anca MotataianuLaura BarcuteanZoltan BajkoAdina StoianSmaranda MaierSeptimiu VoidazanRodica BalasaMDPI AGarticlediabetic neuropathydiabetes mellitusheart rate variabilitynerve conduction studiesMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2005, p 2005 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic neuropathy diabetes mellitus heart rate variability nerve conduction studies Medicine (General) R5-920
spellingShingle	diabetic neuropathy diabetes mellitus heart rate variability nerve conduction studies Medicine (General) R5-920 Anca Motataianu Laura Barcutean Zoltan Bajko Adina Stoian Smaranda Maier Septimiu Voidazan Rodica Balasa Autonomic and Somatic Nerve Functions in Type 2 Diabetes Mellitus Patients: Electrophysiological Aspects
description	Objectives: To investigate the relationship between neurophysiological sensory and motor nerve function parameters, assessed by nerve conduction studies (NCS) with parasympathetic autonomic function and by heart rate variability (HRV) tests in patients with type 2 diabetes mellitus (T2DM). Material and Methods: A total of 161 T2DM patients underwent NCS. Cardiac autonomic response was assessed by HRV tests to deep breathing (HRV DB), to Valsalva manoeuvre, and during postural change from lying to standing. Results: The amplitude of motor response in the median nerve, tibial nerve, and peroneal nerve was associated with reduced HRV DB (<i>p</i> = 0.0001). The amplitude of motor response in the median nerve, tibial nerve, and peroneal nerve was associated with reduced HRV Valsalva (<i>p</i> = 0.0001). The correlation between the amplitude of response in all sensory nerves (sural, median, and ulnar) and HRV DB was statistically significant (<i>p</i> = 0.0001). Conclusion: The results indicate that there is a correlation in T2DM patients between the damage of small myelinated and unmyelinated nerve fibres from cardiac autonomic nerves, assessed by HRV tests and damage of large motor and sensory fibres, assessed by NCS. Based on the above results, a combination of NCS and HRV tests should be considered in the neurophysiological approach to diabetic neuropathy.
format	article
author	Anca Motataianu Laura Barcutean Zoltan Bajko Adina Stoian Smaranda Maier Septimiu Voidazan Rodica Balasa
author_facet	Anca Motataianu Laura Barcutean Zoltan Bajko Adina Stoian Smaranda Maier Septimiu Voidazan Rodica Balasa
author_sort	Anca Motataianu
title	Autonomic and Somatic Nerve Functions in Type 2 Diabetes Mellitus Patients: Electrophysiological Aspects
title_short	Autonomic and Somatic Nerve Functions in Type 2 Diabetes Mellitus Patients: Electrophysiological Aspects
title_full	Autonomic and Somatic Nerve Functions in Type 2 Diabetes Mellitus Patients: Electrophysiological Aspects
title_fullStr	Autonomic and Somatic Nerve Functions in Type 2 Diabetes Mellitus Patients: Electrophysiological Aspects
title_full_unstemmed	Autonomic and Somatic Nerve Functions in Type 2 Diabetes Mellitus Patients: Electrophysiological Aspects
title_sort	autonomic and somatic nerve functions in type 2 diabetes mellitus patients: electrophysiological aspects
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3fbab7685fbb4fb482fe27d702075a96
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Autonomic and Somatic Nerve Functions in Type 2 Diabetes Mellitus Patients: Electrophysiological Aspects

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