Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer

The tumor microenvironment (TME) is a complex ecosystem comprised of cancer cells, stromal cells, and immune cells. Analysis of the composition of TME is essential to assess the prognosis of patients with breast cancer (BC) and the efficacy of different regimes. Treg plays a crucial role in the micr...

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Autores principales:	Jianyu Liu, Xueying Wang, Yuhan Deng, Xin Yu, Hongbin Wang, Zhigao Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	regulatory T cell tumor microenvironment breast cancer immunotherapy neoadjuvant treatment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/3fbac8310572447aadeec835a4ae2137
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spelling	oai:doaj.org-article:3fbac8310572447aadeec835a4ae21372021-11-15T04:29:21ZResearch Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer2234-943X10.3389/fonc.2021.766248https://doaj.org/article/3fbac8310572447aadeec835a4ae21372021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.766248/fullhttps://doaj.org/toc/2234-943XThe tumor microenvironment (TME) is a complex ecosystem comprised of cancer cells, stromal cells, and immune cells. Analysis of the composition of TME is essential to assess the prognosis of patients with breast cancer (BC) and the efficacy of different regimes. Treg plays a crucial role in the microenvironment of breast cancer subtypes, and its function contributes to the development and progression of BC by suppressing anti-tumor immunity directly or indirectly through multiple mechanisms. In addition, conventional treatments, such as anthracycline-based neoadjuvant chemotherapy, and neo-therapies, such as immune-checkpoint blockades, have a significant impact on the absence of Tregs in BC TME, thus gaining additional anti-tumor effect to some extent. Strikingly, Treg in BC TME revealed the predicted efficacy of some therapeutic strategies. All these results suggest that we can manipulate the abundance of Treg to achieve the ultimate effect of both conventional and novel treatments. In this review, we discuss new insights into the characteristics of Treg in BC TME, the impact of different regiments on Treg, and the possibilities of Treg as a predictive marker of efficacy for certain treatments.Jianyu LiuXueying WangYuhan DengXin YuHongbin WangZhigao LiFrontiers Media S.A.articleregulatory T celltumor microenvironmentbreast cancerimmunotherapyneoadjuvant treatmentNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	regulatory T cell tumor microenvironment breast cancer immunotherapy neoadjuvant treatment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	regulatory T cell tumor microenvironment breast cancer immunotherapy neoadjuvant treatment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jianyu Liu Xueying Wang Yuhan Deng Xin Yu Hongbin Wang Zhigao Li Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer
description	The tumor microenvironment (TME) is a complex ecosystem comprised of cancer cells, stromal cells, and immune cells. Analysis of the composition of TME is essential to assess the prognosis of patients with breast cancer (BC) and the efficacy of different regimes. Treg plays a crucial role in the microenvironment of breast cancer subtypes, and its function contributes to the development and progression of BC by suppressing anti-tumor immunity directly or indirectly through multiple mechanisms. In addition, conventional treatments, such as anthracycline-based neoadjuvant chemotherapy, and neo-therapies, such as immune-checkpoint blockades, have a significant impact on the absence of Tregs in BC TME, thus gaining additional anti-tumor effect to some extent. Strikingly, Treg in BC TME revealed the predicted efficacy of some therapeutic strategies. All these results suggest that we can manipulate the abundance of Treg to achieve the ultimate effect of both conventional and novel treatments. In this review, we discuss new insights into the characteristics of Treg in BC TME, the impact of different regiments on Treg, and the possibilities of Treg as a predictive marker of efficacy for certain treatments.
format	article
author	Jianyu Liu Xueying Wang Yuhan Deng Xin Yu Hongbin Wang Zhigao Li
author_facet	Jianyu Liu Xueying Wang Yuhan Deng Xin Yu Hongbin Wang Zhigao Li
author_sort	Jianyu Liu
title	Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer
title_short	Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer
title_full	Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer
title_fullStr	Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer
title_full_unstemmed	Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer
title_sort	research progress on the role of regulatory t cell in tumor microenvironment in the treatment of breast cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3fbac8310572447aadeec835a4ae2137
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Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer

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