Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy

Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the...

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Autores principales:	Yvonne Xinyi Lim, Hexian Lin, Sock Hong Seah, Yoon Pin Lim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hippo pathway cancer oncogene therapeutics reciprocal regulation WW-domain binding protein 2 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3fbd9eb42596497987797ce2776e1413
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spelling	oai:doaj.org-article:3fbd9eb42596497987797ce2776e14132021-11-25T17:11:50ZReciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy10.3390/cells101131302073-4409https://doaj.org/article/3fbd9eb42596497987797ce2776e14132021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3130https://doaj.org/toc/2073-4409Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the Hippo pathway has revealed an increasing number of regulators that are implicated, some being potential therapeutic targets for cancer interventions. WW domain-binding protein 2 (WBP2) is an oncogenic transcriptional co-factor that interacts, amongst others, with two other transcriptional co-activators, YAP and TAZ, in the Hippo pathway. WBP2 was recently discovered to modulate the upstream Hippo signalling components by associating with LATS2 and WWC3. Exacerbating the complexity of the WBP2/Hippo network, WBP2 itself is reciprocally regulated by Hippo-mediated microRNA biogenesis, contributing to a positive feedback loop that further drives carcinogenesis. Here, we summarise the biological mechanisms of WBP2/Hippo reciprocal regulation and propose therapeutic strategies to overcome Hippo defects in cancers through targeting WBP2.Yvonne Xinyi LimHexian LinSock Hong SeahYoon Pin LimMDPI AGarticlehippo pathwaycanceroncogenetherapeuticsreciprocal regulationWW-domain binding protein 2Biology (General)QH301-705.5ENCells, Vol 10, Iss 3130, p 3130 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hippo pathway cancer oncogene therapeutics reciprocal regulation WW-domain binding protein 2 Biology (General) QH301-705.5
spellingShingle	hippo pathway cancer oncogene therapeutics reciprocal regulation WW-domain binding protein 2 Biology (General) QH301-705.5 Yvonne Xinyi Lim Hexian Lin Sock Hong Seah Yoon Pin Lim Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
description	Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the Hippo pathway has revealed an increasing number of regulators that are implicated, some being potential therapeutic targets for cancer interventions. WW domain-binding protein 2 (WBP2) is an oncogenic transcriptional co-factor that interacts, amongst others, with two other transcriptional co-activators, YAP and TAZ, in the Hippo pathway. WBP2 was recently discovered to modulate the upstream Hippo signalling components by associating with LATS2 and WWC3. Exacerbating the complexity of the WBP2/Hippo network, WBP2 itself is reciprocally regulated by Hippo-mediated microRNA biogenesis, contributing to a positive feedback loop that further drives carcinogenesis. Here, we summarise the biological mechanisms of WBP2/Hippo reciprocal regulation and propose therapeutic strategies to overcome Hippo defects in cancers through targeting WBP2.
format	article
author	Yvonne Xinyi Lim Hexian Lin Sock Hong Seah Yoon Pin Lim
author_facet	Yvonne Xinyi Lim Hexian Lin Sock Hong Seah Yoon Pin Lim
author_sort	Yvonne Xinyi Lim
title	Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
title_short	Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
title_full	Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
title_fullStr	Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
title_full_unstemmed	Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
title_sort	reciprocal regulation of hippo and wbp2 signalling—implications in cancer therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3fbd9eb42596497987797ce2776e1413
work_keys_str_mv	AT yvonnexinyilim reciprocalregulationofhippoandwbp2signallingimplicationsincancertherapy AT hexianlin reciprocalregulationofhippoandwbp2signallingimplicationsincancertherapy AT sockhongseah reciprocalregulationofhippoandwbp2signallingimplicationsincancertherapy AT yoonpinlim reciprocalregulationofhippoandwbp2signallingimplicationsincancertherapy
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Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy

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