TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.

Guardado en:
Detalles Bibliográficos
Autores principales: Guoliang Lyu, Yiting Guan, Chao Zhang, Le Zong, Lei Sun, Xiaoke Huang, Li Huang, Lijun Zhang, Xiao-Li Tian, Zhongjun Zhou, Wei Tao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3fc4fb45806142b6abbf012e462c3364
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:3fc4fb45806142b6abbf012e462c3364
record_format dspace
spelling oai:doaj.org-article:3fc4fb45806142b6abbf012e462c33642021-12-02T17:32:47ZTGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging10.1038/s41467-018-04994-z2041-1723https://doaj.org/article/3fc4fb45806142b6abbf012e462c33642018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04994-zhttps://doaj.org/toc/2041-1723Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.Guoliang LyuYiting GuanChao ZhangLe ZongLei SunXiaoke HuangLi HuangLijun ZhangXiao-Li TianZhongjun ZhouWei TaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Guoliang Lyu
Yiting Guan
Chao Zhang
Le Zong
Lei Sun
Xiaoke Huang
Li Huang
Lijun Zhang
Xiao-Li Tian
Zhongjun Zhou
Wei Tao
TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging
description Cellular senescence is associated with epigenetic remodeling. Here, the authors report that TGF-β signaling promotes miR-29 mediated loss of H4K20me3 thus accelerating senescence.
format article
author Guoliang Lyu
Yiting Guan
Chao Zhang
Le Zong
Lei Sun
Xiaoke Huang
Li Huang
Lijun Zhang
Xiao-Li Tian
Zhongjun Zhou
Wei Tao
author_facet Guoliang Lyu
Yiting Guan
Chao Zhang
Le Zong
Lei Sun
Xiaoke Huang
Li Huang
Lijun Zhang
Xiao-Li Tian
Zhongjun Zhou
Wei Tao
author_sort Guoliang Lyu
title TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging
title_short TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging
title_full TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging
title_fullStr TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging
title_full_unstemmed TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging
title_sort tgf-β signaling alters h4k20me3 status via mir-29 and contributes to cellular senescence and cardiac aging
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/3fc4fb45806142b6abbf012e462c3364
work_keys_str_mv AT guolianglyu tgfbsignalingaltersh4k20me3statusviamir29andcontributestocellularsenescenceandcardiacaging
AT yitingguan tgfbsignalingaltersh4k20me3statusviamir29andcontributestocellularsenescenceandcardiacaging
AT chaozhang tgfbsignalingaltersh4k20me3statusviamir29andcontributestocellularsenescenceandcardiacaging
AT lezong tgfbsignalingaltersh4k20me3statusviamir29andcontributestocellularsenescenceandcardiacaging
AT leisun tgfbsignalingaltersh4k20me3statusviamir29andcontributestocellularsenescenceandcardiacaging
AT xiaokehuang tgfbsignalingaltersh4k20me3statusviamir29andcontributestocellularsenescenceandcardiacaging
AT lihuang tgfbsignalingaltersh4k20me3statusviamir29andcontributestocellularsenescenceandcardiacaging
AT lijunzhang tgfbsignalingaltersh4k20me3statusviamir29andcontributestocellularsenescenceandcardiacaging
AT xiaolitian tgfbsignalingaltersh4k20me3statusviamir29andcontributestocellularsenescenceandcardiacaging
AT zhongjunzhou tgfbsignalingaltersh4k20me3statusviamir29andcontributestocellularsenescenceandcardiacaging
AT weitao tgfbsignalingaltersh4k20me3statusviamir29andcontributestocellularsenescenceandcardiacaging
_version_ 1718380181078409216

Ejemplares similares