A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity

Summary: The obesity epidemic significantly contributes to overall morbidity and mortality. Bariatric surgery is the gold standard treatment for obesity and metabolic dysfunction, yet the mechanisms by which it exerts metabolic benefit remain unclear. Here, we demonstrate a model of vertical sleeve...

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Autores principales:	Julia L. Nugent, Amar Singh, Keith M. Wirth, Scott Hunter Oppler, Laura Hocum Stone, Jody L. Janecek, Adam C. Sheka, Scott Kizy, Meghan E.G. Moore, Christopher Staley, Bernhard J. Hering, Sabarinathan Ramachandran, Sayeed Ikramuddin, Melanie L. Graham
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Immunology Obesity medicine Surgery Science Q
Acceso en línea:	https://doaj.org/article/3fc8a538e22247af90c96b7b143479e7
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spelling	oai:doaj.org-article:3fc8a538e22247af90c96b7b143479e72021-11-26T04:37:43ZA nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity2589-004210.1016/j.isci.2021.103421https://doaj.org/article/3fc8a538e22247af90c96b7b143479e72021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013924https://doaj.org/toc/2589-0042Summary: The obesity epidemic significantly contributes to overall morbidity and mortality. Bariatric surgery is the gold standard treatment for obesity and metabolic dysfunction, yet the mechanisms by which it exerts metabolic benefit remain unclear. Here, we demonstrate a model of vertical sleeve gastrectomy (VSG) in nonhuman primates (NHP) that mimics the complexity and outcomes in humans. We also show that VSG confers weight loss and durable metabolic benefit, where equivalent caloric intake in shams resulted in significant weight gain following surgery. Furthermore, we show that VSG is associated with early, weight-independent increases in bile acids, short-chain fatty acids, and reduced visceral adipose tissue (VAT) inflammation with a polarization of VAT-resident immunocytes toward highly regulatory myeloid cells and Tregs. These data demonstrate that this strongly translational NHP model can be used to interrogate factors driving successful intervention to unravel the interplay between physiologic systems and improve therapies for obesity and metabolic syndrome.Julia L. NugentAmar SinghKeith M. WirthScott Hunter OpplerLaura Hocum StoneJody L. JanecekAdam C. ShekaScott KizyMeghan E.G. MooreChristopher StaleyBernhard J. HeringSabarinathan RamachandranSayeed IkramuddinMelanie L. GrahamElsevierarticleImmunologyObesity medicineSurgeryScienceQENiScience, Vol 24, Iss 12, Pp 103421- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunology Obesity medicine Surgery Science Q
spellingShingle	Immunology Obesity medicine Surgery Science Q Julia L. Nugent Amar Singh Keith M. Wirth Scott Hunter Oppler Laura Hocum Stone Jody L. Janecek Adam C. Sheka Scott Kizy Meghan E.G. Moore Christopher Staley Bernhard J. Hering Sabarinathan Ramachandran Sayeed Ikramuddin Melanie L. Graham A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity
description	Summary: The obesity epidemic significantly contributes to overall morbidity and mortality. Bariatric surgery is the gold standard treatment for obesity and metabolic dysfunction, yet the mechanisms by which it exerts metabolic benefit remain unclear. Here, we demonstrate a model of vertical sleeve gastrectomy (VSG) in nonhuman primates (NHP) that mimics the complexity and outcomes in humans. We also show that VSG confers weight loss and durable metabolic benefit, where equivalent caloric intake in shams resulted in significant weight gain following surgery. Furthermore, we show that VSG is associated with early, weight-independent increases in bile acids, short-chain fatty acids, and reduced visceral adipose tissue (VAT) inflammation with a polarization of VAT-resident immunocytes toward highly regulatory myeloid cells and Tregs. These data demonstrate that this strongly translational NHP model can be used to interrogate factors driving successful intervention to unravel the interplay between physiologic systems and improve therapies for obesity and metabolic syndrome.
format	article
author	Julia L. Nugent Amar Singh Keith M. Wirth Scott Hunter Oppler Laura Hocum Stone Jody L. Janecek Adam C. Sheka Scott Kizy Meghan E.G. Moore Christopher Staley Bernhard J. Hering Sabarinathan Ramachandran Sayeed Ikramuddin Melanie L. Graham
author_facet	Julia L. Nugent Amar Singh Keith M. Wirth Scott Hunter Oppler Laura Hocum Stone Jody L. Janecek Adam C. Sheka Scott Kizy Meghan E.G. Moore Christopher Staley Bernhard J. Hering Sabarinathan Ramachandran Sayeed Ikramuddin Melanie L. Graham
author_sort	Julia L. Nugent
title	A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity
title_short	A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity
title_full	A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity
title_fullStr	A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity
title_full_unstemmed	A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity
title_sort	nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/3fc8a538e22247af90c96b7b143479e7
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A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity

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