Long-Term Outcomes and Predictive Factors of Hospitalized Patients with Severe Ulcerative Colitis Treated with Intravenous Corticosteroids

<i>Background and Aims</i>: Treatment with intravenous corticosteroids (IVCS) is a mainstay in the management of acute severe ulcerative colitis (UC). Although most patients respond to IVCS, little is known about the long-term outcomes. In this study, we assessed the long-term outcomes o...

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Autores principales:	Elena De Cristofaro, Silvia Salvatori, Irene Marafini, Francesca Zorzi, Norma Alfieri, Martina Musumeci, Livia Biancone, Emma Calabrese, Giovanni Monteleone
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	inflammatory bowel disease acute severe UC steroids Medicine R
Acceso en línea:	https://doaj.org/article/3fc90ebcfc03486682ee54e4736e57ee
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spelling	oai:doaj.org-article:3fc90ebcfc03486682ee54e4736e57ee2021-11-25T18:02:33ZLong-Term Outcomes and Predictive Factors of Hospitalized Patients with Severe Ulcerative Colitis Treated with Intravenous Corticosteroids10.3390/jcm102254132077-0383https://doaj.org/article/3fc90ebcfc03486682ee54e4736e57ee2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5413https://doaj.org/toc/2077-0383<i>Background and Aims</i>: Treatment with intravenous corticosteroids (IVCS) is a mainstay in the management of acute severe ulcerative colitis (UC). Although most patients respond to IVCS, little is known about the long-term outcomes. In this study, we assessed the long-term outcomes of IVCS in a real-life cohort. <i>Methods</i>: Disease activity, clinical relapse (partial Mayo score >4), the need for steroids or other maintenance therapies and the rates of colectomy and re-hospitalization were evaluated in consecutive patients admitted to the Tor Vergata University hospital between 2010 and 2020 for acute severe UC who responded to IVCS. <i>Results:</i> Eighty-eight patients were followed up with for a median period of 46 (range 6–133) months. Of these, 56 (64%) patients were treated with 5-aminosalycilic acid and 32 (36%) with immunomodulators or biologics after discharge. A total of 60 out of 88 patients (68%) relapsed, 28 (32%) were re-hospitalized, and 15 (17%) underwent a colectomy with no difference between the two maintenance therapy groups. The multivariate analysis showed that patients in clinical remission 6 months after discharge had a lower risk of relapse during the follow-up. <i>Conclusions:</i> Nearly two-thirds of patients with acute UC responding to IVCS experienced relapse after a median follow-up of 4 years, and this was not influenced by the maintenance therapy.Elena De CristofaroSilvia SalvatoriIrene MarafiniFrancesca ZorziNorma AlfieriMartina MusumeciLivia BianconeEmma CalabreseGiovanni MonteleoneMDPI AGarticleinflammatory bowel diseaseacute severe UCsteroidsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5413, p 5413 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammatory bowel disease acute severe UC steroids Medicine R
spellingShingle	inflammatory bowel disease acute severe UC steroids Medicine R Elena De Cristofaro Silvia Salvatori Irene Marafini Francesca Zorzi Norma Alfieri Martina Musumeci Livia Biancone Emma Calabrese Giovanni Monteleone Long-Term Outcomes and Predictive Factors of Hospitalized Patients with Severe Ulcerative Colitis Treated with Intravenous Corticosteroids
description	<i>Background and Aims</i>: Treatment with intravenous corticosteroids (IVCS) is a mainstay in the management of acute severe ulcerative colitis (UC). Although most patients respond to IVCS, little is known about the long-term outcomes. In this study, we assessed the long-term outcomes of IVCS in a real-life cohort. <i>Methods</i>: Disease activity, clinical relapse (partial Mayo score >4), the need for steroids or other maintenance therapies and the rates of colectomy and re-hospitalization were evaluated in consecutive patients admitted to the Tor Vergata University hospital between 2010 and 2020 for acute severe UC who responded to IVCS. <i>Results:</i> Eighty-eight patients were followed up with for a median period of 46 (range 6–133) months. Of these, 56 (64%) patients were treated with 5-aminosalycilic acid and 32 (36%) with immunomodulators or biologics after discharge. A total of 60 out of 88 patients (68%) relapsed, 28 (32%) were re-hospitalized, and 15 (17%) underwent a colectomy with no difference between the two maintenance therapy groups. The multivariate analysis showed that patients in clinical remission 6 months after discharge had a lower risk of relapse during the follow-up. <i>Conclusions:</i> Nearly two-thirds of patients with acute UC responding to IVCS experienced relapse after a median follow-up of 4 years, and this was not influenced by the maintenance therapy.
format	article
author	Elena De Cristofaro Silvia Salvatori Irene Marafini Francesca Zorzi Norma Alfieri Martina Musumeci Livia Biancone Emma Calabrese Giovanni Monteleone
author_facet	Elena De Cristofaro Silvia Salvatori Irene Marafini Francesca Zorzi Norma Alfieri Martina Musumeci Livia Biancone Emma Calabrese Giovanni Monteleone
author_sort	Elena De Cristofaro
title	Long-Term Outcomes and Predictive Factors of Hospitalized Patients with Severe Ulcerative Colitis Treated with Intravenous Corticosteroids
title_short	Long-Term Outcomes and Predictive Factors of Hospitalized Patients with Severe Ulcerative Colitis Treated with Intravenous Corticosteroids
title_full	Long-Term Outcomes and Predictive Factors of Hospitalized Patients with Severe Ulcerative Colitis Treated with Intravenous Corticosteroids
title_fullStr	Long-Term Outcomes and Predictive Factors of Hospitalized Patients with Severe Ulcerative Colitis Treated with Intravenous Corticosteroids
title_full_unstemmed	Long-Term Outcomes and Predictive Factors of Hospitalized Patients with Severe Ulcerative Colitis Treated with Intravenous Corticosteroids
title_sort	long-term outcomes and predictive factors of hospitalized patients with severe ulcerative colitis treated with intravenous corticosteroids
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3fc90ebcfc03486682ee54e4736e57ee
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Long-Term Outcomes and Predictive Factors of Hospitalized Patients with Severe Ulcerative Colitis Treated with Intravenous Corticosteroids

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